Caspase 1 (CASP1) (Middle Region) Peptid

Details zu Produkt Nr. ABIN974471, Anbieter: Anmelden zum Anzeigen
Proteinname
  • ICE
  • IL1BC
  • P45
  • Il1bc
  • Ice
  • CASP1
  • CG5370
  • DCP-1
  • DCP1
  • Dcp1
  • Dmel\\CG5370
  • ccp1
  • dcp-1
  • dcp1
  • l(2)01862
  • l(2)02132
  • caspase 1
  • caspase 1, apoptosis-related cysteine peptidase
  • caspase 4, apoptosis-related cysteine peptidase
  • Death caspase-1
  • caspase-1
  • caspase
  • caspase recruitment domain-containing protein 16
  • caspase 4
  • CASP1
  • Casp1
  • CASP4
  • Dcp-1
  • Caspase1
  • LOC5564196
  • LOC451519
Protein Region
Middle Region
Spezies
Human
11
2
2
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Geblockter Antikörper anti-Caspase 1 Antikörper (CASP1) (Middle Region) (ABIN2787901)
Sequenz LQTRVLNKEE MEKVKRENAT VMDKTRALID SVIPKGAQAC QICITYICEE
Produktmerkmale This is a synthetic peptide designed for use in combination with anti-CASP1 Antibody(ARP58983_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Reinigung Purified
Proteinname Caspase 1 (CASP1)
Hintergrund This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms.

Alias Symbols: ICE, IL1BC, P45

Protein Interaction Partner: AR,ATN1,ATXN3,HTT,PSEN1,AR,ATN1,ATXN3,BCAP31,BCL2L1,BID,CARD16,CARD17,CARD8,CASP1,CASP14,CAST,CDK11A,CDK11B,EGFR,HTT,IL18,IL1B,LMNA,MAPT,NEDD4,NFE2L2,NLRC4,NLRP1,NOD1,PAK1,PARK2,PARP1,PLA2G4A,PSEN1,PSEN2,PYCARD,RIPK2,TFAP2A,BCAP31,CARD8,CASP1,CASP10,CASP1

Protein Size: 383
Molekulargewicht 10 kDa
Gen-ID 834
NCBI Accession NM_001223, NP_001214
UniProt P29466
Applikations-hinweise Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.