This is a synthetic peptide designed for use in combination with anti-BRE Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration
1 mg/mL
Buffer
Final peptide concentration is 1 mg/mL in PBS.
Handhabung
Avoid repeated freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target
BRE
(Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
Synonyme
brcc4 Peptide, brcc45 Peptide, BRE Peptide, LOC100231620 Peptide, BRCC4 Peptide, BRCC45 Peptide, 6030405P19Rik Peptide, AI429776 Peptide, B830038C02Rik Peptide, im:7141046 Peptide, zgc:110368 Peptide, BRISC and BRCA1 A complex member 2 Peptide, brain and reproductive organ-expressed (TNFRSF1A modulator) Peptide, BRISC and BRCA1 A complex member 2 L homeolog Peptide, babam2 Peptide, BABAM2 Peptide, Babam2 Peptide, BRE Peptide, babam2.L Peptide
Hintergrund
BRE is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. BRE probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. BRE may play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. BRE may also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway anf regulate TNF-alpha signaling through its interactions with TNFRSF1A, however these effects may be indirect.
Alias Symbols: BRCC4, BRCC45
Protein Interaction Partner: BABAM1,GFI1B,ATG2A,BABAM1,BARD1,BRCA1,BRCA2,BRCC3,COPS5,DHRS7B,FAM175A,FAM175B,FAS,FKBP8,LRPPRC,MMS19,NCOA3,PHB,RAD51,RPN2,SHMT2,SLC25A13,SSR3,SUMO1,TMX3,TNFRSF1A,TP53,TTC28,UBC,UBE2D1,UGGT2,UIMC1,USP7