A synthetic peptide for use as a blocking control in assays to test for specificity of MTHFD1 antibody, Alternative Names: MTHFD1 control peptide, MTHFD1 antibody Blocking Peptide, Anti-MTHFD1 Blocking Peptide, Methylenetetrahydrofolate Dehydrogenase Blocking Peptide, Nadp+ Dependent 1 Methenyltetrahydrofolate Cyclohydrolase Formyltetrahydrofolate Synthetase Blocking Peptide, MTHFC Blocking Peptide, MTHFD Blocking Peptide, MTHFD1, MTHFD-1, MTHFD 1, MTHFD-1 Blocking Peptide, MTHFD 1 Blocking Peptide
Aufreinigung
The antibody is affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
MTHFD1 possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain.