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Excessive gestational weight gain (GWG) was noticed in women that were overweight or obese before pregnancy. Study found a significant association between the variant genotype of GNB3 rs5443 and excessive GWG. Similarly, the presence of variant genotype of PNPLA3 rs738409 in mothers was associated with a lower ponderal index (PI) in their newborns. Study found no associations between GCKR rs780094 and birth weight or PI.
In patients with metabolic syndrome, T-allele carriers had 1.6 times higher risk of obesity than C-allele homozygotes. T825T genotype carriers had 2.7 times higher risk of hypertension compared to the carriers of S825S genotype of the S825T polymorphism.
study of single nucleotide polymorphisms of the CYP11B2, GNB3 and NOS3 genes in various ethnic groups of Arctic zone of Yakutia suffering from arterial hypertension
In a case-control study, the determinants of hypertension were three genotypes of SNP in GNB3 (TT; CT; and CC) and two dietary salt categories on the basis of the level of sodium consumption representing high (>4800 mg/day) and low-sodium.
Significant genetic differences of GNB3 rs5443 exist between Southeastern European Caucasians and other populations. Cluster headache pathophysiology and pharmacotherapy response may be affected by GNB3 polymorphisms.
The polymorphism of FTO gene rs17817449 and GNB3 gene rs5443 (C825T) may be a genetic determinant of obesity in Saudi population whereas impact of MC4R Asn274Ser change could not be detected.
the GNB3 C825T polymorphism may contribute to increased risk of cancer, especially of thyroid carcinoma (meta-analysis).
Guanine nucleotide-binding protein (GNB3) C825T polymorphism is not associated with type 2 diabetes mellitus (T2DM).
Meta-analysis: GNB3 C825T polymorphism is related to increased essential hypertension exclusively in Caucasians.
Our study indicates that variations in OXTR and Gbeta3 genes are specifically associated with presence and severity of Separation Anxiety in childhood and adulthood, but not with depression or anxiety in general.
Our results demonstrate the potential use of a GNB3-specific antisense morpholino, as a pharmacogenetic therapy for essential hypertension
No relationship was found between the studied polymorphisms (14094 ACE gene, rs1800469 gene TGFbeta1, GNB3 gene rs5443, rs5186 AGTR1 gene) and the occurrence of primary vesicoureteral reflux. TT genotype polymorphism rs5443 of the GNB3 gene may be a protective factor for improved renal function in patients with primary vesicoureteral reflux.
Interactions between GNB3, CREB1 and negative life events were revealed. Further evidence is provided about the role of the environment in genetic vulnerability to major depression.
Bipolar patients with the TT genotype had a lower BMI, smaller waist circumference, and lower levels of lipids and leptin than those with the CT or CC genotypes undergoing the valproic acid treatment course.
Expressed in cone photoreceptors and ON-bipolar cells, Gbeta3 is essential in phototransduction and ON-bipolar cell signaling.
Mutational analysis of GNB3 in a cohort of 58 subjects with CSNB identified a sporadic case individual with a homozygous GNB3 mutation
The GNB3 TT genotype is a risk factor for coronary artery disease independent of other established cardiovascular risk factors in Chinese hypertensive patients.
The combined effects of ACE and GNB3 polymorphisms showed that no pulmonary hypertension patients with the ACE/GNB3 II/TT genotype exhibited clinical worsening.
Although not statistically significant, women who carried the GNB3 T risk allele gained 6 pounds more than noncarriers, and mean 6-month postpartum BMI differed by 2.2 kg/m(2) between homozygous women
TT genotype of GNbeta3 C825T is more common among patients with functional dyspepsia than among healthy controls.
Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia.
A transgenic model carries an extra copy of GNB3, weighs significantly more than wild-type littermates, and has excess fat accumulation. GNB3 is highly expressed in the brain, consistent with G-protein signaling involved in satiety and/or metabolism.
These results suggest that the main role of Gbeta3 in cones is to establish optimal levels of transducin heteromer in the outer segment, thereby indirectly contributing to robust response properties.
The results of this study showed that Gbeta(3) may play a role in synaptic maintenance since in its absence, the number of invaginating rod bipolar dendrites is greatly reduced, a deficit that was not observed at 3 weeks, the end of the developmental period.
Gbeta3 subunit is coexpressed in physiologically ON-type cone bipolar cells with Ggamma13 and Gbeta4 but is not present in OFF-type bipolar cells.
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.
G protein, beta-3 subunit
, GTP-binding regulatory protein beta-3 chain
, guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3
, guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
, hypertension associated protein
, transducin beta chain 3
, guanine nucleotide binding protein, beta 3
, G protein beta-subunit
, guanine nucleotide binding protein (G protein), beta 3
, guanine nucleotide-binding protein, beta-3 subunit
, GTP-binding protein beta-3 subunit short isoform
, transducin beta-3-subunit
, guanine nucleotide binding protein (G protein), beta polypeptide 3
, Transducin beta chain 3
, guanine nucleotide binding protein (G protein), beta polypeptide 3, like