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our data indicate that ATR and ATM are both needed for intestinal stem cell maintenance and proliferation; ATR seems to play a bigger role than does ATM.
TCTP (zeige TPT1 Proteine) has a role in regulating ATM activity to control genome stability and organ development in Drosophila melanogaster
A stringent requirement for the conserved function of Ataxia Telangiectasia Mutated (ATM) in telomere protection during early embryonic development, is identified.
ATM is primarily required for the meiotic DSB repair response, which includes functions in DNA damage repair and negative feedback control over the level of programmed DSBs during meiosis.
Molecular genetic characterization of Drosophila ATM conserved functional domains.
ATM checkpoint kinase plays a role in telomere maintenance that is independent of telomerase regulation.
Drosophila ATM and Mre11 (zeige MRE11A Proteine) are essential for the G2/M checkpoint induced by low-dose irradiation.
Results suggest that ATM and ATR protect telomere integrity by safeguarding chromatin architecture that favors the loading of telomere-elongating, capping, and silencing proteins.
Dna2 co-localizes in foci with RPA (zeige RPA1 Proteine) and is found in a complex with replication fork components And-1 and Mcm10 (zeige MCM10 Proteine). Dna2 interacts with the DSB repair and checkpoint proteins Nbs1 (zeige NLRP2 Proteine) and ATM.
ATM and ATR prevent accumulation of chromosomal abnormalities by promoting Mre11 (zeige MRE11A Proteine)/Rad50 (zeige RAD50 Proteine)/Nbs1 (zeige NLRP2 Proteine) dependent recovery of collapsed replication forks.
ATM and ATR phosphorylate the functionally critical replication protein Mcm2 (zeige MCM2 Proteine) during both DNA damage and replication checkpoint responses in Xenopus egg extracts
PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts
Data show that ATM (ataxia-telangiectasia mutated) regulates Xenopus TopBP1 (zeige TOPBP1 Proteine) by phosphorylating serine 1131 and thereby strongly enhancing association of TopBP1 (zeige TOPBP1 Proteine) with ATR(ATM and Rad3-related).
ATM and ATR control mitotic events in vertebrate cells by targeting CEP63 (zeige CEP63 Proteine) and centrosome dependent spindle assembly.
These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1 (zeige TOPBP1 Proteine)-dependent activation of ATR-ATRIP (zeige ATRIP Proteine) in response to double-stranded DNA breaks.
The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways.
molecular cloning of the coding sequence of the catalytic domain of the zebrafish homologue of ATM
Characterization of ataxia telangiectasia protein.
ATM was downregulated in gastric cancer patients in Xinjiang, especially for Uygurs and Kazaks, which suggested ATM to be an independent indicator of prognosis for GC therapy.
The mRNA levels of ATR (zeige ANTXR1 Proteine) and ATM and the expression of ATR (zeige ANTXR1 Proteine) and ATM protein in NPC (zeige NPC1 Proteine) tissues were significantly higher than those in adjacent normal tissues. The colony formation assay showed that the colony-forming rate decreased, showing radiation dose-dependent and CGK (zeige PRKG1 Proteine)-733 concentration-dependent manners.
study expands the spectrum of ATM pathogenic variants in Iran.
Our data showed that relative TP53 (zeige TP53 Proteine) mRNA expression was not significantly altered in both tissues exposed to lasers. For ATM, relative mRNA expression in skin tissue was not significantly altered, but in muscle tissue, laser exposure increased relative ATM mRNA expression. Low-level red and infrared laser radiations alter ATM mRNA expression related to DNA stability in skeletal muscle tissue.
The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication
ATM could be activated by lung cancer-associated TNF-alpha (zeige TNF Proteine), up-regulate MMP-13 (zeige MMP13 Proteine) expression and thereby augment tumor metastasis
these results indicate that ATM loss seems to be an early event in non-small cell lung cancer carcinogenesis and is an independent prognostic factor associated with worse survival in stage II/III patients.
Low ATM gene expression is associated with breast cancer.
Our results demonstrate that sorafenib combined with KU-55933 ( specific ATM inhibitor)treatment does effectively inhibit proliferation of HCC (zeige FAM126A Proteine) cell lines synergistically. These data suggests that KU-55933 may be a promising chemosensitizer to sorafenib in the treatment of HCC (zeige FAM126A Proteine)
Authors further showed that LRRK2 phosphorylation is abolished in the absence of ATM, suggesting that LRRK2 phosphorylation requires ATM.
Ataxia telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. We engineered a novel porcine model of AT
ATM influenced the meiotic and cytoplasmic maturation of porcine oocytes.
ATM plays critical role in arsenite induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint signaling molecules.
radiation-induced eNOS (zeige NOS3 Proteine) activation in bovine aortic endothelial cells is regulated by ATM and HSP90 (zeige HSP90 Proteine)
ATM haplodeficiency decreases fibroblast senescence and vascular endothelial growth factor (zeige VEGF Proteine) production and impaired angiogenesis in response to myocardial infarction, leading to accelerated heart failure.
H2AX (zeige H2AFX Proteine) shows a similar influence as ATM.
The ATM protein is a key mediator of H2O2 preconditioning.
ATM is the primary kinase responsible for phosphorylation of Hsp90alpha (zeige HSP90AA2 Proteine) after exposure ionizing radiation.
These findings define an antagonistic function of ATM and MAPK7 (zeige MAPK7 Proteine) in the thymocyte response to DNA damage, and suggest that the lack of MAPK7 (zeige MAPK7 Proteine) inhibits thymic lymphoma growth in Atm-/- mice by partially restoring the DNA damage response in thymocytes.
ATM/G6PD (zeige G6PD Proteine)-driven redox metabolism promotes FLT3 (zeige FLT3 Proteine) inhibitor resistance in acute myeloid leukemia (zeige BCL11A Proteine) that can be successfully reversed.
Baf60b (zeige SMARCD2 Proteine), a member of the SWI/SNF chromatin remodeling complex (zeige SMARCA2 Proteine), links chromatin opening to ATM activation by facilitating ATM recruitment to the open chromatin regions of a panel of hepatic gene loci.
Results demonstrate that alterations in ATM levels are responsible for pronounced and anticipated GABAergic development and function. Since GABA transmission is strongly linked to the correct brain development and plasticity, this study lays basics for both a more clear comprehension of mechanisms associated with brain development.
These data indicate that defective Atm reduces the redox homeostasis of the testis and genetic integrity of sperm by regulating glutathione levels independently from G6PDH (zeige G6PD Proteine) activity.
WSB1 (zeige WSB1 Proteine) is one of the key players of early oncogenic events through ATM degradation and destruction of the tumorigenesis barrier.
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates\; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
, ataxia telangiectasia mutated
, ataxia telengiesctasia mutated
, ataxia-telangiectasia mutated
, drosophila ATM
, ataxia telangiectasia mutated (includes complementation groups A, C and D)
, ataxia telangiectasia mutated protein
, serine-protein kinase ATM-like
, ataxia telangiectasia mutated (atm)
, A-T mutated
, AT mutated
, TEL1, telomere maintenance 1, homolog
, serine-protein kinase ATM
, Ataxia telangiectasia gene mutated in human beings
, ataxia telangiectasia mutated homolog
, A-T mutated homolog
, ATM (ataxia telangiectasia mutated)
, ataxia telangiectasia gene mutated in human beings