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ATM Produkte

(Ataxia Telangiectasia Mutated (ATM))
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates\; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010].

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Ausgewählte ATM Kategorien

ATM Antikörper

High quality antibodies with extensive validation data.

ATM ELISA Kits

Reliable ELISA kits for a wide range of species.

ATM Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene ATM Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, IHC, ELISA, FACS, FM
Validierungen
  • (70)
  • (12)
Kat. Nr. ABIN6656104
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation WB, IHC, ELISA, FM
Validierungen
  • (3)
  • (5)
Kat. Nr. ABIN6657494
Menge 25 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse
Applikation WB, IHC, ELISA, IP, IF, FACS, ICC
Validierungen
  • (7)
Kat. Nr. ABIN363380
Menge 0.05 mL
Datenblatt Datenblatt

Empfohlene ATM ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6953956
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6953957
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Semi-Quantitative Cell ELISA
Validierungen
Kat. Nr. ABIN5526689
Menge 96 tests
Datenblatt Datenblatt

Empfohlene ATM Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1345996
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1345994
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN7393904
Menge 100 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren ATM Produkten

Gautam, Stanley, Owen, Bridge: "Localization of the kinase Ataxia Telangiectasia Mutated to Adenovirus E4 mutant DNA replication centers is important for its inhibitory effect on viral DNA accumulation." in: Virology, Vol. 527, pp. 47-56, (2019) (PubMed).

Yin, Xu, Chang, Zeng, Chen, Wang, Groth, Foo, Liang, Hu, Huang: "N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway." in: Molecular cancer, Vol. 18, Issue 1, pp. 11, (2019) (PubMed).

Meister-Broekema, Freilich, Jagadeesan, Rauch, Bengoechea, Motley, Kuiper, Minoia, Furtado, van Waarde, Bird, Rebelo, Zuchner, Pytel, Scherer, Morelli, Carra, Weihl, Bergink, Gestwicki, Kampinga: "Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks." in: Nature communications, Vol. 9, Issue 1, pp. 5342, (2019) (PubMed).

Dworak, Makosa, Chatterjee, Jividen, Yang, Snow, Simke, Johnson, Kelley, Paschal: "A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling." in: Aging cell, Vol. 18, Issue 1, pp. e12851, (2019) (PubMed).

Xu, Ma, Zeng, Zhao, Tao, Chen, Groth, Liang, Hu, Huang: "ATM deficiency promotes progression of CRPC by enhancing Warburg effect." in: Endocrine-related cancer, Vol. 26, Issue 1, pp. 59-71, (2019) (PubMed).

Chen, Chen, Huang, Gu, Qiu, Qian, Shao, Zhang, Hu, Li, He, Zhou, Abdel-Wahab, Zhang, Fu: "The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations." in: Molecular cell, Vol. 69, Issue 3, pp. 412-425.e6, (2019) (PubMed).

Kreis, Gallrein, Rojas-Puente, Mack, Kroon, Dinkel, Willmes, Murk, Tom-Dieck, Schuman, Kirstein, Eickholt: "ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans." in: Nature communications, Vol. 10, Issue 1, pp. 486, (2019) (PubMed).

Li, Mahon, Sweeney, Verschueren, Kantamani, Li, Hennigs, Marciano, Diebold, Abu-Halawa, Elliott, Sa, Guo, Wang, Cao, Guignabert, Sollier, Nickel, Kaschwich, Cimprich, Rabinovitch: "PPARγ Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis." in: Cell reports, Vol. 26, Issue 5, pp. 1333-1343.e7, (2019) (PubMed).

Rosina, Langone, Giuliani, Cerquone Perpetuini, Reggio, Calderone, Fuoco, Castagnoli, Gargioli, Cesareni: "Osteogenic differentiation of skeletal muscle progenitor cells is activated by the DNA damage response." in: Scientific reports, Vol. 9, Issue 1, pp. 5447, (2019) (PubMed).

Parisotto, Grelet, El Bizri, Dai, Terzic, Eckert, Gargowitsch, Bornert, Metzger: "PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo." in: The Journal of experimental medicine, Vol. 215, Issue 6, pp. 1749-1763, (2019) (PubMed).

Synonyme und alternative Namen zu ATM

telomere fusion (tefu), ATM serine/threonine kinase L homeolog (atm.L), ATM serine/threonine kinase (atm), ATM serine/threonine kinase (ATM), ataxia telangiectasia mutated (atm), ataxia telangiectasia mutated (EDI_100660), ataxia telangiectasia mutated (CpipJ_CPIJ001772), ataxia telangiectasia mutated (BDBG_08252), ataxia telangiectasia mutated (PAAG_02532), ataxia telangiectasia mutated (MCYG_05088), ataxia telangiectasia mutated (VDBG_06833), ataxia telangiectasia mutated (atm) (ACLA_015700), serine/threonine-protein kinase ATM (LOC5565620), ataxia telangiectasia mutated (MGYG_07634), ataxia telangiectasia mutated (PGTG_14279), ATM serine/threonine kinase (Atm), ataxia telangiectasia mutated (Atm), AI256621, at1, AT1, ATA, ATC, ATD, atdc, ATDC, ATE, ATM, Atm, atm, atm/tefu, C030026E19Rik, CG6535, dATM, Dmel\\CG6535, tef, Tefu, tel1, TEL1, telo1, TELO1, Xatm

Bezeichner auf Proteinebene für ATM

  • CG6535-PB
  • ataxia telangiectasia mutated
  • ataxia telengiesctasia mutated
  • ataxia-telangiectasia mutated
  • drosophila ATM
  • tefu-PB
  • chunp9624
  • ataxia telangiectasia mutated (includes complementation groups A, C and D)
  • ataxia telangiectasia mutated protein
  • serine-protein kinase ATM-like
  • ataxia telangiectasia mutated (atm)
  • A-T mutated
  • AT mutated
  • TEL1, telomere maintenance 1, homolog
  • serine-protein kinase ATM
  • Ataxia telangiectasia gene mutated in human beings
  • ataxia telangiectasia mutated homolog
  • A-T mutated homolog
  • ATM (ataxia telangiectasia mutated)
  • ataxia telangiectasia gene mutated in human beings
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