Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Human Retinoic Acid Receptor alpha Protein expressed in Wheat germ - ABIN1317431
Schulz, Paus, Frey, Schmid, Kohl, Mennerich, Winkler, Gillardon: Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells. in PLoS ONE 2011
Show all 2 Pubmed References
Our findings unveil a novel essential oncogenic activity of PML (zeige PML Proteine)/RARA in Acute promyelocitic leukemia
Findings reveal a previously unrecognized role of c-Myc (zeige MYC Proteine) as a potential ceRNA for PML (zeige PML Proteine)/RARalpha in acute promyelocytic leukemia (zeige PML Proteine).
RARalpha regulates Arp2/3-mediated actin cytoskeletal dynamics through a non-genomic signaling pathway
It has been shown that the AP-1 (zeige FOSB Proteine) family member JunB (zeige JUNB Proteine) and retinoic acid receptor alpha (RARa) mediate catalase (zeige CAT Proteine) transcriptional activation and repression, respectively, by controlling chromatin remodeling through a histone deacetylases-dependent mechanism.
Work identifies the TP53 (zeige TP53 Proteine) tumor suppressor as a novel target through which NPM1 (zeige NPM1 Proteine)-RARA impacts leukemogenesis.
Dual small interfering RNA (siRNA) silencing of RARalpha and RARgamma reversed RA blockade of P4-induced CK5 (zeige KRT5 Proteine). Using promoter deletion analysis, we identified a region 1.1 kb upstream of the CK5 (zeige KRT5 Proteine) transcriptional start site that is necessary for P4 activation and contains a putative progesterone response element (PRE
High RARA expression is associated with acute myeloid leukemia (zeige BCL11A Proteine).
Data suggest that the binding of Z-10 to RXRalpha (zeige RXRA Proteine) inhibited the interaction of RXRalpha (zeige RXRA Proteine) with PML (zeige PML Proteine)-RARalpha, leading to Z-10's selective induction of PML (zeige PML Proteine)-RARalpha degradation.
PML (zeige PML Proteine)-RARa bcr1 (zeige BCR Proteine) fusion is not responsible for colorectal tumor development.
overexpression of NLS (zeige ALDH1A2 Proteine)-RARalpha promoted the proliferation of APL (zeige FASL Proteine) cells and inhibited their differentiation via the PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) signaling pathway.
RARalpha competes with other PFN2a-binding proteins bearing PRMs and involved in actin filaments elongation. Consequently, the actin filament network is altered and MEFs adhesion is decreased. This novel role opens novel avenues for the understanding of pathologies characterized by increased levels of cytoplasmic RARalpha.
These data suggest that impairment of cardiac RARalpha signaling may be a novel mechanism that is directly linked to pathological stimuli-induced diastolic dysfunction.
Retinoic acid receptor alpha agonist all trans retinoic acid can protect the liver from ischemia reperfusion injury by promoting autophagy, which is dependent on Foxo3 (zeige FOXO3 Proteine)/p-Akt (zeige AKT1 Proteine)/Foxo1 (zeige FOXO1 Proteine) signaling.
both the PML (zeige PML Proteine)-RARA-driven competitive transplantation advantage and development of acute promyelocytic leukemia (zeige PML Proteine) (APL (zeige FASL Proteine)) required DNMT3A (zeige DNMT3A Proteine)
the reprogramming of epiblast stem cells into embryonic stem cell-like cells also requires low levels of retinoic acid (RA), which can modulate Wnt (zeige WNT2 Proteine) signalling through physical interactions of RARs (zeige RARS Proteine) with beta-catenin (zeige CTNNB1 Proteine).
our findings challenge the predominant model in the field and we propose that PML (zeige PML Proteine)/RARA initiates leukemia by subtly shifting cell fate decisions within the promyelocyte compartment.
DNA-binding-defective PML (zeige PML Proteine)/RARA mutants could not repress the transcription of retinoic acid regulated genes.
although X-RARA fusion proteins have been suggested to act by blocking retinoid-dependent transcriptional programs , we observed a surprising paucity of natural retinoids capable of transactivating Gal4 (zeige LGALS4 Proteine)-RARA in primary mouse bone marrow cells
The results indicate a physiological role for RARgamma as a negative regulator of osteoclastogenesis in vivo and in vitro, and reveal distinct influences of RARalpha and RARgamma in bone structure regulation.
Data suggest that retinoic acid and GM-CSF (zeige CSF2 Proteine)-induced retinal dehydrogenase 2 (RALDH2 (zeige ALDH1A2 Proteine)) expression in dendritic cells requires cooperative binding of transcription factor Sp1 (zeige SP1 Proteine) via the RA receptor/retinoid X receptor (zeige RXRB Proteine) complex to the Aldh1a2 (zeige ALDH1A1 Proteine) promoter.
Increased expression of mammary TRbeta1 (zeige THRB Proteine) and DIO2 (zeige DIO2 Proteine), and decreased RXRalpha (zeige RXRA Proteine), provide a mechanism to increase thyroid hormone (zeige PTH Proteine) activity within the mammary gland during lactation.
results show role for retinoic acid receptor (zeige RARB Proteine) as a regulator of spatial patterning of the pre-placodal ectoderm (PPE)through Tbx1 and RIPPLY3; demonstrate that Ripply3, acting downstream of RAR (zeige RAB40B Proteine) signaling, is key player in establishing boundaries in the PPE
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
retinoic acid receptor alpha
, retinoic acid receptor, alpha
, retinoic acid receptor alpha-like
, nuclear receptor subfamily 1 group B member 1
, nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form
, retinoic acid nuclear receptor alpha variant 1
, retinoic acid nuclear receptor alpha variant 2
, retinoic acid receptor, alpha polypeptide
, RAR alpha 1
, rar alpha
, xRAR alpha
, retinoic acid receptor alpha 1 isoform