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ERalpha (zeige ESR1 Proteine) and ERbeta mRNA expression was significantly higher (p < 0.05) in tumour tissues relative to their paired normal mucosa and correlated inversely with survival outcome
ESR2 single nucleotide polymorphism is associated with poor ovarian response in Egyptian women undergoing IVF (zeige SCN5A Proteine) procedure.
ERbeta expression conferred cell sensitivity, as patient-derived AML (zeige RUNX1 Proteine) cells with high levels of ERb were sensitive, whereas cells with low ERb were insensitive to diosmetin. Knockdown of ERb confirmed resistance, whereas overexpression enhanced sensitivity to diosmetin, which was demonstrated to be mediated by reactive oxygen species signaling.
Data report for the first time that ERbeta inversely regulates miR (zeige MLXIP Proteine)-10b and miR (zeige MLXIP Proteine)-145, which are critical modulators of functional properties, epithelial to mesenchymal transition and extracellular matrix composition of breast cancer cells. ERbeta together with miR (zeige MLXIP Proteine)-10b and miR (zeige MLXIP Proteine)-145, are key players for the initiation of breast cancer cell aggressiveness.
the mRNA expression levels of ERbeta isoforms are downregulated in sporadic colorectal cancer and in FAP individuals. T3/T4 tumours also presented decreased expression of ERbeta. Additionally, the expression levels of ERbeta1 and ERbeta5 were associated with the probability of disease-free survival.
Gender differences were observed in ERalpha (zeige ESR1 Proteine) expression in normal livers. Sub-cellular expression of both ER subtypes is altered in hepatitis C virus (HCV) cirrhosis and HCV-related hepatocellular carcinoma livers as compared to normals and correlates with the expression of inflammatory and oncogenic markers.
factors that regulate the alternative splicing of ERs remain unknown. We demonstrate novel evidence supporting a potential biological feedback loop where 17beta-estradiol regulates the RNA-binding protein (zeige PTBP1 Proteine) Nova1 (zeige NOVA1 Proteine), which, in turn, regulates the alternative splicing of ERbeta
significant prognostic roles of ERalpha (zeige ESR1 Proteine), ERbeta and aromatase (zeige CYP19A1 Proteine) were discovered in the in prostate cancer specimens of our large multicenter cohort.
A dual role of the association between AGO2 (zeige EIF2C2 Proteine) and ERbeta in luminal-like breast cancer cells in the nucleus and the cytoplasm, for the regulation of gene expression at both the transcriptional and post-transcriptional level.
We found higher nuclear (n)ERalpha (zeige ESR1 Proteine) and nERbeta5 and lower cytoplasmic (c)ERalpha (zeige ESR1 Proteine) expression in advanced ovarian cancers. Lower ERbeta1 expression was also detected in high grade cancers. Loss of nERalpha and cERbeta2 expression were observed in clear cell histological subtypes. Higher nERbeta5 and lower cERbeta5 expression were associated with serous/clear cell subtypes, poor disease-free and overall survival.
Comprehensive genetic analysis for differential functions of esr1, esr2a, and esr2b in fish reproduction.
although esr2b mutant fish showed unaltered antibacterial responses, they were unable to mount an effective antiviral response upon viral challenge.
This study revealed similar patterns of transcript abundance across reproductive morphs for ERbeta1, ERbeta2, ERalpha (zeige ESR1 Proteine), and aromatase in the forebrain and saccule.
It was concluded that morpholino (MO) oligonucleotid technology in zebrafish embryos is an good approach for investigating the interplay of estrogen receptor (zeige ESR1 Proteine) subtypes in a true physiological context.
during embryogenesis two of the three 17beta-estradiol receptor genes, esr1 and esr2b are expressed, and in presence of ligand the mRNA levels of these two genes increase
Data show that temperature and photoperiod significantly influence the transcription of the estrogen-responsive genes, Vtg1, Vtg2, ER alpha (zeige ESR1 Proteine) and ER beta after a 21-day exposure to endocrine-disrupting chemicals.
Cloning of the cDNAs corresponding to three oestrogen receptors (esr1 (zeige ESR1 Proteine), ERalpha (zeige ESR1 Proteine); esr2b, ERbeta1; and esr2a (zeige ESR1 Proteine), ERbeta2 ).
Data show that the hepatic expression of estrogen receptor alpha (zeige ESR1 Proteine), beta1 and beta2 genes responds differently to estradiol.
genistein binds and activates the three zebrafish estrogen receptors ERalpha (zeige ESR1 Proteine), ERbeta-A and ERbeta-B (zeige ESR1 Proteine) and induces apoptosis in an ER-independent manner
The mRNA expression of ER-alpha (zeige ESR1 Proteine) and ER-beta in the hypothalamus of developing male and female bovines, is reported.
ER-alpha (zeige ESR1 Proteine) is detected predominantly in the soma whereas ER-beta is only present in the nucleus of a few cells in the frontal cortex.
fetal ovary of cattle has the steroidogenic enzyme aromatase (zeige CYP19A1 Proteine) to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary
there are different levels of ERalpha (zeige ESR1 Proteine), ERbeta and PR in bovine oviducts at different cycle stages in vivo
The expression of estrogen and progesterone receptors in ovarian follicular structures from cows with cystic ovarian disease (COD (zeige SNRPB Proteine)) and a comparison of these with normal ovarian structures are reported.
These data indicate that PGF2alpha, TNFalpha (zeige TNF Proteine) and IFNgamma regulate ERalpha (zeige ESR1 Proteine) and ERbeta mRNA expressions in bovine luteal cells.
Roles of IGF-I (zeige IGF1 Proteine) and the estrogen, androgen and IGF-I (zeige IGF1 Proteine) receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.
an 17b-estradiol-induced increase in the proliferation of rhesus retinal capillary endothelial cells may be mediated by the action of ERb.
Estradiol can weakly modulate the motility and this effect is strictly associated with GPER (zeige GPER Proteine) and not with ESR1 (zeige ESR1 Proteine) and ESR2. The subcellular localization of GPER (zeige GPER Proteine) in the neck on stallion sperm is coherent with this effect.
The presence of a single isoform of ESR1 (zeige ESR1 Proteine) (66kDa (zeige SF3A2 Proteine)) and ESR2 (61kDa) was found by Western-blot analysis in samples from seven stallions and the expression of the seven transmembrane estradiol binding receptor GPER (zeige GPER Proteine) in colt testis.
expression of estrogen receptor alpha (zeige ESR1 Proteine) and beta and progesterone receptor (zeige PGR Proteine) in equine microplacentomes gives evidence for a role of placental steroids as regulators of placental function
There were no statistical differences between the BB genotype and the AB genotype of ESR2 locus in regard to the examined traits. However, a noticeable superiority (P < 0.01) of the BB genotype compared to the homozygous AA genotype, adding almost 2 piglets/litter in TNB and NBA trait, was found.
steroid hormones, AhR (zeige AHR Proteine) and estrogen receptor beta are affected by TCDD and genistein in granulosa cells of medium porcine follicles
Results suggest that expression levels of protease activated receptors 1 and 2 (PAR-1 (zeige F2R Proteine) and PAR-2 (zeige F2RL1 Proteine)) associate with breast cancer outcome in an estrogen receptor (ER (zeige ESR1 Proteine))-dependent manner.
results might shed new light on the roles of estrogen receptor (zeige ESR1 Proteine) 2(ESR2) in spermatogenesis as candidate for boar fertility
Downregulation of the ERs, particularly ERalpha (zeige ESR1 Proteine) in the myometrium and endometrial stroma, might be a relevant mechanism in the antagonism of estrogenic effects by dihydrotestosterone in the pig uterus.
the results of the present study suggest the involvement of estrogen receptor beta in estrogen modulation of pig epididymal function
ERbeta mRNA was found only in Sertoli cells in the testis.
positive staining for ERalpha (zeige ESR1 Proteine) in the nuclei of skeletal muscle cells, while the ERbeta stain showed positive signals in nuclei and cytoplasm of skeletal myofibers and myoblasts derived from satellite cells
ESR2 gene polymorphisms are associated with litter size.
The objective of this study was to search for polymorphisms in the coding region of the estrogen receptors 1 and 2 (ESR1 (zeige ESR1 Proteine) and ESR2) and to analyze the effects of these variants and the well known intronic ESR1 (zeige ESR1 Proteine) PvuII polymorphism on litter size.
Estrogen receptor beta modulates mitochondrial permeability transition by regulating CypD interaction with OSCP (zeige ATP5O Proteine).
These data demonstrate chemoarchitectural differences in ERbeta neurons of the mouse paraventricular nucleus.
Study found that estrogen receptor beta (ERbeta) was expressed in the motoneurons of lumbar ventral horn. ERalpha (zeige ESR1 Proteine) and ERbeta were mainly localized in the nuclei of motoneurons with less immunoreactivity in the cytoplasm.
Data suggest that expression of Usp19 in skeletal muscle can be regulated by dietary factors; here, supplementation with phytoestrogen daidzein down-regulates Usp19 expression via Esrb signaling and increases skeletal muscle mass. (Usp19 = ubiquitin-specific peptidase 19; Esrb = estrogen receptor beta)
The role of ERbeta in opposing AR signaling, proliferation, and inflammation suggests that ERbeta-selective agonists may be used to prevent progression of prostate cancer, prevent fibrosis and development of benign prostatic hyperplasia, and treat prostatitis.
Data suggest that one alternative splicing variant of Esr2 is "super-activated" by xenoestrogens; here, samples isolated from soil around a landfill site in the United Kingdom appear to contain xenoestrogens that induce cholangitis.
The administration of ICI182,780, which is an agonist of G-protein coupled estrogen receptor (zeige ESR1 Proteine) (GPER (zeige GPER Proteine)) and an antagonist of ERa and ERb, did not result in protection; however, ICI182,780 significantly blocked EDC-mediated cardioprotection, indicating participation of ERalpha (zeige ESR1 Proteine) and/or ERbeta
ERbeta might be the target protein of arctigenin responsible for inhibition of mTORC1 activation and resultant prevention of Th17 cell differentiation and colitis development.
Taken together, the above results clearly demonstrated an mTORC2 (zeige CRTC2 Proteine)-dependent regulation of actin polymerization that contributed to the effects of ERalpha (zeige ESR1 Proteine) and ERbeta on spatial learning, which may provide a novel target for the prevention and treatment of E2-related dementia in the aged population
Results provide evidence that ERbeta prevents cardiac fibroblasts to undergo fibrosis development.
cloned three ER subtypes (ERalpha (zeige ESR1 Proteine), ERbeta1, and ERbeta2), and examined their developmental expression in the gonads of females and males during embryonic and larval development
The expression of androgen receptors, estrogen receptor beta, and bone morphogenetic protein 2b (zeige BMP4 Proteine) in male and female Japanese and Thai medaka are reported.
The main functional structure domains of the ESR2 in a Jining Gray female goat have been described.
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.
estrogen nuclear receptor beta variant a
, estrogen nuclear receptor beta variant b
, estrogen receptor beta
, estrogen receptor beta 4
, nuclear receptor subfamily 3 group A member 2
, estrogen receptor beta1
, estrogen receptor beta 2
, estrogen receptor 2 (ER beta)
, estradiol receptor beta
, steroid receptor
, ER beta
, oestrogen receptor beta
, estrogen receptor 2 beta
, Nuclear receptor subfamily 3 group A member 2
, estrogen receptor beta-like
, estrogen receptor 2 (beta)