anti-Ratte (Rattus) DLL3 Antikörper für ELISA

Recommended DLL3 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
delta Like Protein 3 (DLL3) Antikörper
  • SCDO1
  • pu
  • pudgy
  • delta like canonical Notch ligand 3
  • delta-like 3 (Drosophila)
  • DLL3
  • Dll3
Epitop
AA 222-234
28
15
11
8
7
4
3
3
2
1
1
1
Reaktivität
Maus, Ratte (Rattus)
87
23
3
3
2
2
1
1
1
1
Wirt
Kaninchen
84
2
2
Klonalität
Polyklonal
Konjugat
Dieser DLL3 Antikörper ist unkonjugiert
7
7
7
5
4
4
1
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
69
40
39
34
13
13
12
2
2
1
Hersteller
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Hersteller Produkt- Nr.
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Produktnummer ABIN1834890
$ 566.50
Zzgl. Versandkosten $45.00

General

Antigen delta Like Protein 3 (DLL3) Antikörper
Epitop AA 222-234
(28), (15), (11), (8), (7), (4), (3), (3), (2), (1), (1), (1)
Reaktivität Maus, Ratte (Rattus)
(87), (23), (3), (3), (2), (2), (1), (1), (1), (1)
Wirt Kaninchen
(84), (2), (2)
Klonalität
Polyklonal
Konjugat Dieser DLL3 Antikörper ist unkonjugiert
(7), (7), (7), (5), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation ELISA, Western Blotting (WB)
(69), (40), (39), (34), (13), (13), (12), (2), (2), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-DLL3 Antikörper

Target Details DLL3 Anwendungsinformationen Handhabung Bilder
Spezifität Rabbit anti-mouse Delta-like protein 3 recognizes mouse Delta-like protein 3 (DLL3), one of the five major ligands of the Notch signalling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4. The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumor progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. DLL3 is predominantly expressed in the neuroectoderm and paraxial mesoderm during embryogenesis, where it plays a role in somite segmentation, during early development. DLL3 acts as a regulator of Notch 1, as an inhibitor of primary neurogenesis, and studies in mice have linked DLL3-Notch signalling with liver regeneration, and developmental defects. More than 25 mutations in the DLL3 gene are known to be responsible for the autosomal recessive skeletal malformation condition known as spondylocostal dysostosis type 1 (SCDO1), associated with vertebral and rib segmentation defects.
Reinigung Purified
Immunogen Keyhole Limpet Hemocyanin (KLH) conjugated peptide sequence CSPEHGYCEEPDE, corresponding to amino acids 222-234 of mouse DLL3. Percent identity by BLAST analysis: Mouse, Rat (100%), Hamster (92%), Galago, Rabbit, Pig, Bovine, Guinea pig (85%).

Type of Immunogen: Synthetic peptide
Isotyp IgG

Target Details DLL3

Produktdetails anti-DLL3 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung Delta3 / DLL3 (DLL3 Antibody Abstract)
Hintergrund Name/Gene ID: DLL3

Synonyms: DLL3, Delta (Drosophila)-like 3, Delta-like 3 (Drosophila), Delta-like protein 3, Delta3, Drosophila Delta homolog 3, SCDO1
Gen-ID 10683
Pathways Notch Signalweg

Anwendungsinformationen

Produktdetails anti-DLL3 Antikörper Target Details DLL3 Handhabung Bilder zurück nach oben
Applikationshinweise Approved: ELISA, WB (1:100 - 1:500)
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-DLL3 Antikörper Target Details DLL3 Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration Lot specific
Buffer PBS, 0.09 % sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C,-20 °C
Informationen zur Lagerung +4°C or -20°C, Avoid repeated freezing and thawing.