anti-Maus DLL3 Antikörper für ELISA

Recommended DLL3 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
delta Like Protein 3 (DLL3) Antikörper
  • SCDO1
  • pu
  • pudgy
  • delta like canonical Notch ligand 3
  • delta-like 3 (Drosophila)
  • DLL3
  • Dll3
Epitop
AA 222-234
28
15
11
8
7
4
3
3
2
1
1
1
Reaktivität
Human, Maus
86
23
3
3
2
2
2
1
1
1
Wirt
Kaninchen
84
2
2
Klonalität
Polyklonal
Konjugat
Dieser DLL3 Antikörper ist unkonjugiert
7
7
7
5
4
4
1
1
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
67
38
37
32
13
13
12
2
2
1
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN2473315
$ 361.06
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN1834890 ELISA WB Rabbit IgG AA 222-234 Anmelden zum Anzeigen Polyclonal
1 ABIN2252401 ELISA WB Rabbit IgG AA 222-234 Anmelden zum Anzeigen Polyclonal

General

Antigen delta Like Protein 3 (DLL3) Antikörper
Epitop AA 222-234
(28), (15), (11), (8), (7), (4), (3), (3), (2), (1), (1), (1)
Reaktivität Human, Maus
(86), (23), (3), (3), (2), (2), (2), (1), (1), (1)
Wirt Kaninchen
(84), (2), (2)
Klonalität
Polyklonal
Konjugat Dieser DLL3 Antikörper ist unkonjugiert
(7), (7), (7), (5), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation ELISA, Western Blotting (WB)
(67), (38), (37), (32), (13), (13), (12), (2), (2), (1)
Pubmed 1 Publikation vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-DLL3 Antikörper

Target Details DLL3 Anwendungsinformationen Handhabung Referenzen für anti-DLL3 Antikörper (ABIN2473315) Bilder
Spezifität Rabbit anti-mouse Delta-like protein 3 recognises mouse Delta-like protein 3 (DLL3), one of the five major ligands of the Notch signalling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4. The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumour progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. DLL3 is predominantly expressed in the neuroectoderm and paraxial mesoderm during embryogenesis, where it plays a role in somite segmentation, during early development. DLL3 acts as a regulator of Notch 1, as an inhibitor of primary neurogenesis, and studies in mice have linked DLL3-Notch signalling with liver regeneration, and developmental defects. More than 25 mutations in the DLL3 gene are known to be responsible for the autosomal recessive skeletal malformation condition known as spondylocostal dysostosis type 1 (SCDO1), associated with vertebral and rib segmentation d
Kreuzreaktivität Human
Produktmerkmale Purified IgG
Reinigung Purified
Immunogen Keyhole Limpet Hemocyanin (KLH) conjugated peptide sequence CSPEHGYCEEPDE, corresponding to amino acids 222-234 of mouse DLL3.
Isotyp IgG

Target Details DLL3

Produktdetails anti-DLL3 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-DLL3 Antikörper (ABIN2473315) Bilder zurück nach oben
Antigen
Andere Bezeichnung delta-LIKE PROTEIN 3 (DLL3 Antibody Abstract)
Hintergrund Synonyms: DLL3
Gen-ID 10683, 13389
UniProt O88516, Q9NYJ7
Pathways Notch Signalweg

Anwendungsinformationen

Produktdetails anti-DLL3 Antikörper Target Details DLL3 Handhabung Referenzen für anti-DLL3 Antikörper (ABIN2473315) Bilder zurück nach oben
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-DLL3 Antikörper Target Details DLL3 Anwendungsinformationen Referenzen für anti-DLL3 Antikörper (ABIN2473315) Bilder zurück nach oben
Format Liquid
Konzentration 1.0 mg/mL

Referenzen für anti-DLL3 Antikörper (ABIN2473315)

Produktdetails anti-DLL3 Antikörper Target Details DLL3 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Bray: "Notch signalling: a simple pathway becomes complex." in: Nature reviews. Molecular cell biology, Vol. 7, Issue 9, pp. 678-89, 2006

Bilder

Produktdetails anti-DLL3 Antikörper Target Details DLL3 Anwendungsinformationen Handhabung Referenzen für anti-DLL3 Antikörper (ABIN2473315) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-delta Like Protein 3 (DLL3) (AA 222-234) antibody (ABIN2473315) anti-delta Like Protein 3 (DLL3) (AA 222-234) antibody