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anti-Human DLL3 Antikörper:
anti-Mouse (Murine) DLL3 Antikörper:
anti-Rat (Rattus) DLL3 Antikörper:
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Human Polyclonal DLL3 Primary Antibody für ELISA, WB - ABIN2473315
Bray: Notch signalling: a simple pathway becomes complex. in Nature reviews. Molecular cell biology 2006
our results indicated epidermal growth factor-like domain multiple 7 protein participates in growth hormone-secreting pituitary adenoma proliferation and invasion regulation via Notch2/DLL3 signaling pathway. These findings raised the possibility that epidermal growth factor-like domain multiple 7 protein might serve as a useful biomarker to assess growth hormone-secreting pituitary adenoma invasion and prognosis
The Dll3 was rarely detectable in (zeige PIK3CA Antikörper) the (zeige AKT1 Antikörper) para-carcinoma tissues, but positi (zeige NOTCH1 Antikörper)ve in 82.1% of non-small cell cancer tissues.
Both global haplotype and individual haplotype analyses showed that the haplotypes of SNP1/SNP2/SNP3/SNP4/SNP5 did not correlate with the disease (P >0.05). Together, these data suggest that genetic variants of the DLL3 gene are not associated with CS in the Chinese Han population.
DLL3 was silenced by methylation in human human hepatocellular carcinoma and it negatively regulates the growth of human hepatocellular carcinoma cells.
We suggest that the three human DLL3 mutations associated with spondylocostal dysplasia are also functionally equivalent to the Dll3(neo) null allele in mice.
mutations in DLL3 cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis
no novel or previously described mutations are present in our cohort, indicating that DLL3 mutations may not be a major cause of congenital scoliosis.
The intracellular region of Notch (zeige NOTCH1 Antikörper) ligands Dll1 (zeige DLL1 Antikörper) and Dll3 regulates their trafficking and signaling activity
Structural deformities of the vertebral column and adjacent ribs in the pudgy mouse are caused by mutations in Dll3. Review.
Dll3 overexpression promoted PI3K/Akt (zeige AKT1 Antikörper) signaling through inhibiting Notch (zeige NOTCH1 Antikörper) signaling in lung cancer.
O-fucosylation of DLL3 is required for its function during somitogenesis.
Intriguing changes are observed in the cranio-caudal (zeige CAD Antikörper) borders of multifidus muscle in mutant Dll3 and Lfng (zeige LFNG Antikörper) models of idiopathic scoliosis.
Dll3 has a unique function during T-cell development that is distinct from the role played by the other DSL ligands of Notch (zeige NOTCH1 Antikörper).
Dll3 targets Notch1 (zeige NOTCH1 Antikörper) for lysosomal degradation preventing Notch1 (zeige NOTCH1 Antikörper) from undergoing post-translational processing.
Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm.
DLL3 knockout mice have segmentation and neural defects
Notch (zeige NOTCH1 Antikörper) ligands, including Delta-like1 and 3 and Jagged1 (zeige JAG1 Antikörper) and Jagged2 (zeige JAG2 Antikörper), show distinct expression patterns in the developing and adult brain overlapping that of Notch1 (zeige NOTCH1 Antikörper)
Data describe the genetic interactions between Dll1 (zeige DLL1 Antikörper), Dll3, Mesp2 (zeige Mesp2 Antikörper) and Psen1 (zeige PSEN1 Antikörper), and the roles of Dll1 (zeige DLL1 Antikörper)- and Dll3-Notch (zeige NOTCH1 Antikörper) pathways, with or without Psen1 (zeige PSEN1 Antikörper), in rostrocaudal patterning.
This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene.
delta-like protein 3
, drosophila Delta homolog 3