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serum level did not change after tonsillectomy alone but decreased significantly after steroid pulse therapy in patients with IgA nephropathy
Elevated serum TNFR2 may be a possible marker of COPD (zeige ARCN1 Proteine) in asymptomatic smokers and ex-smokers.
TNFR2 promoted Adriamycin resistance in breast cancer cells by regulating the DNA damage repair.
Serum TNFR2 is a biomarker for patients with chronic kidney disease.
Data indicate activators of tumor necrosis factor receptor 2 (TNFR2) and a potential role for this target in immunotherapy.
In this study, we identified a novel association between ANCA levels, TNFRSF1B genotype and decreased circulating TNFR2 levels, which may be reflective of the underlying biological mechanisms that determine clinical expression and/or response to certain therapies.
In Han Chinese population of Hunan province, TNFRSF1B+676 gene polymorphisms are not associated with the genetic risk of rheumatoid arthritis
Coadministration of either ATROSAB or EHD2 (zeige EHD2 Proteine)-scTNFR2 into the magnocellular nucleus basalis significantly protected cholinergic neurons and their cortical projections against cell death, and reverted the neurodegeneration-associated memory impairment in a passive avoidance paradigm. Simultaneous blocking of TNFR1 (zeige TNFRSF1A Proteine) and TNFR2 signaling, however, abrogated the therapeutic effect
Results showed that TNFR2 was upregulated in papillary thyroid carcinoma tissues, and its expression is regulated by H19 (zeige NCKAP1 Proteine).
The TNFRSF1Brs3397 variant may play a role in modulating the risk of rheumatoid arthritis, but does not provide strong evidence of an impact of TNFRSF1B variants in determining response to anti-TNF (zeige TNF Proteine) drugs.
These results show an unclear effect of considered T>C polymorphism on TNF-RII gene expression in bovine leukocytes and they suggest the involvement of BLV in modifying the TNF-RII expression in BLV-infected cows.
These results suggest that the endometrium might lower the TNF (zeige TNF Proteine) concentration in the blastocyst by (1) regulating TNF (zeige TNF Proteine) secretion into the uterine fluid and (2) inducing decreased TNF (zeige TNF Proteine) and TNFR2 mRNA transcription in the embryo.
These results suggest that TNF-alpha (zeige TNF Proteine) sources include immune cells, as well as large and small luteal cells, and that TNF-RI (zeige TNFRSF1A Proteine) and TNF-RII are present in the luteal cells of the bovine corpus luteum.
The expression and cellular localization of tumor necrosis factor-alpha (TNF (zeige TNF Proteine)) and its receptors (TNFRI (zeige TNFRSF1A Proteine) and TNFRII) mRNAs and proteins, were determined.[TNFRII]
Retinal ischemia results in increased expression of TNF-alpha (zeige TNF Proteine) and its receptors (TNF-R1 (zeige TNFRSF1A Proteine) and TNF-R2).
Porcine TNFR2 (1,125 bp, 375 amino acid residues), which contains specific amino acid region of transmembrane, indicated high identities with human and murine TNFR2
TNFR2 sensitizes macrophages for endogenous TNF (zeige TNF Proteine)-induced TNFR1 (zeige TNFRSF1A Proteine)-mediated necroptosis
study reports an important role for TNFR2 on low-affinity-primed secondary effector CD8 (zeige CD8A Proteine)+ T cells; results demonstrate the importance of TNF (zeige TNF Proteine) signaling in low-affinity, cross-reactive CD8 (zeige CD8A Proteine)+ T cell responses during heterologous immunity
TNF (zeige TNF Proteine) plays an inhibitory role in modulating myocardial SDF-1 (zeige CXCL12 Proteine) production and blockade of TNF (zeige TNF Proteine) signaling by ablation of TNFR1 (zeige TNFRSF1A Proteine) and TNFR2 genes increased SDF-1 (zeige CXCL12 Proteine) expression in the heart. These data expand on TNF (zeige TNF Proteine) signaling-initiated mechanisms in myocardium, which may lend a more complete understanding of SDF-1 (zeige CXCL12 Proteine) and TNFR (zeige TNFRSF1A Proteine)-derived actions in hopes of advancing ischemic heart injury treatments.
Results suggest that elevated TNF (zeige TNF Proteine) in the heart, via TNFR1 (zeige TNFRSF1A Proteine) and TNFR2, restrains cardiomyocyte differentiation of resident cardiac stem cells and may enhance adrenergic activation, both effects that would reduce the effectiveness of endogenous cardiac repair and the response to exogenous stem cell therapy, while promoting adverse cardiac remodeling.
Report chronic inflammatory multiorgan hepatobiliary pancreatitis, along with fibrosis and calculi formation induced by oral dibutyltin administration in TNFR1 (zeige TNFRSF1A Proteine)/R2 deficient mice.
These findings implicate TNF (zeige TNF Proteine)-receptor signaling cascades in the regulation of homeostatic plasticity of denervated networks and suggest an important role for TNFalpha (zeige TNF Proteine)-signaling in the course of neurological diseases accompanied by deafferentation.
TNF (zeige TNF Proteine) receptor 1 (TnfR1 (zeige TNFRSF1A Proteine)) signaling is believed to be a major mediator of the cytotoxicity of Tnf-a (zeige TNF Proteine) through activation of caspases.
our findings implicate TNFR2 in supporting myeloid-derived suppressor cells -mediated immune suppression and metastasis in the liver
TNFR2 blockade appears to disrupt commensal bacteria-host immune symbiosis to reveal autoimmune demyelination in genetically susceptible mice.
TNFR2 protects mice from colitis by inhibiting the expansion of colonic CD8 (zeige CD8A Proteine)(+) T cells.
Targeted gene knockdown of TNFRSF1B in zebrafish embryos results in the induction of a caspase-8 (zeige CASP8 Proteine), caspase-2 (zeige CASP2 Proteine) and P53 (zeige TP53 Proteine)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (zeige CASP3 Proteine).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
, p75 TNF receptor
, p80 TNF-alpha receptor
, soluble TNFR1B variant 1
, tumor necrosis factor beta receptor
, tumor necrosis factor binding protein 2
, tumor necrosis factor receptor 2
, tumor necrosis factor receptor superfamily member 1B
, tumor necrosis factor receptor type II
, tumor necrosis factor receptor-II
, tumor necrosis factor receptor superfamily, member 1B
, TNF receptor beta chain
, p75 TNFR