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demonstrate for the first time exosomal enrichment of G-protein-coupled receptor kinase (GRK) 5 and GRK6 (zeige GRK6 Antikörper), both of which regulate Src (zeige SRC Antikörper) and IGF-IR signaling and have been implicated in cancer.
Data suggest that perturbation of interface formed between large lobe of kinase domain of GRK5 and the RHD (regulator of G protein signaling homology domain) leads to higher phosphorylation activity/activation of kinase activity.
The role of GRK5 single nucleotide polymorphisms in postoperative atrial fibrillation susceptibility following coronary artery bypass grafting among Chinese population
Candidate gene eQTL (zeige EQTN Antikörper) showed a trans-acting association between variants of G protein-coupled receptor kinase 5 gene (zeige GPD1 Antikörper), previously linked to altered BB response, and high expression of VOPP1 (zeige VOPP1 Antikörper).
Further, we will also present potential therapeutic strategies (i.e. small molecule inhibition, gene therapy) that may have potential in combating the deleterious effects of GRK5 in heart failure.
Suggest a common regulatory pattern for the beta(1)-AR/GRK5 which is independent of cellular type or pathology.
We demonstrated that the SNPs and the related haplotypes of GRK5 could play a central role in predisposing Parkinson disease patients to cognitive impairment.
Thus, we provided new insight into the function of GRKs in agonist-unstimulated GPCR (zeige NMUR1 Antikörper) trafficking using a recombinant AM1 receptor and further determined the region of the CLR C-tail responsible for this GRK (zeige GRK4 Antikörper) function.
ADORA2A (zeige ADORA2A Antikörper) and GRK5 gene variants may influence the etiology of malaria infection.
A significant difference in the frequency of GRK5 polymorphism was found between Takotsubo cardiomyopathy patients and controls, supporting a genetic predisposition to this cardiac syndrome.
Along with other supporting evidence, the authors propose that GRK5 deficiency selectively renders basal forebrain cholinergic neurons more vulnerable to degeneration.
Overall, these data suggest that GRK5 negatively regulates CXCL1/KC (zeige CXCL1 Antikörper) levels during bacterial pneumonia but that the role of GRK5 in the clinical outcome in this model is dependent on the bacterial dose.
Generated mice with genetic knockout (KO) of the G protein-coupled receptor kinase (GRK) 5 gene (zeige GPD1 Antikörper) by microinjection of TALEN mRNA. TALEN vectors were designed to target exons 1, 3, and 5 of the mouse GRK5 gene.
These results of this study suggest that GRK5 deficiency indeed makes the mice more susceptible to wide range of behavioral impairments, including cognitive impairments.
MOR (zeige OPRM1 Antikörper) phosphorylation is regulated by agonist-selective recruitment of distinct GRK (zeige GRK4 Antikörper) isoforms that influence different opioid-related behaviors. Modulation of GRK5 function could serve as a new approach for preventing addiction to opioids.
GRK5, acting in a kinase independent manner, is a facilitator of NFAT (zeige NFATC1 Antikörper) activity and part of a DNA-binding complex responsible for pathological hypertrophic gene transcription.
influence of GRK5 on NF-kappaB (zeige NFKB1 Antikörper) expression and activity
these data identified GRK5 as a positive regulator of insulin (zeige INS Antikörper) sensitivity.
metoprolol is a biased ligand that selectively activates a G protein-independent and GRK5/beta-arrestin2 (zeige ARRB2 Antikörper)-dependent pathway, and induces cardiac fibrosis.
These results define myocyte GRK5 as a critical regulator of pathological cardiac growth after ventricular pressure overload, supporting its role as an endogenous (patho)-physiological HDAC (zeige HDAC3 Antikörper) kinase.
potential GRK5 interacting proteins and the association of GRK5 with DDB1 in cell and the regulation of GRK5 level by DDB1-CUL4 ubiquitin ligase complex-dependent proteolysis pathway
GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.
GRK2 (zeige ADRBK1 Antikörper) and GRK5 control cardiac function as well as morphogenesis during development although with different morphological outcomes.
Results identify GRK5/6 as novel kinases for the single transmembrane receptor LRP6 (zeige LRP5 Antikörper) during Wnt (zeige WNT2 Antikörper) signaling.
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).
, g protein-coupled receptor kinase GRK5
, G protein-coupled receptor kinase 5
, G protein-coupled receptor kinase 6