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These results demonstrate that the ESCRT machinery, and in particular VPS4, plays a critical role in the early stages of PV infection.
Continuous ESCRT-III remodelling by dynamic subunit turnover is regulated by Vps4 to mediate membrane remodelling during cytokinesis.
associations were noted between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila
These results point to the existence of previously undetected biological functions of the FTase alpha subunit that includes control of intracellular membrane trafficking.
these experiments suggest that miR-16 and VPS4a expression are altered in end-stage heart failure and in response to unloading with a left ventricular assist device
Ca2+-dependent accumulation of ESCRT III-Vps4 complex following large focal injury to the cell membrane and identify the role of ALG-2 as the initiator of sequential ESCRT III-Vps4A/B complex assembly.
Vps4A may function as a tumor suppressor, which utilizes exosomes as mediators to regulate the secretion and uptake of miRNAs in hepatoma cells; these observations provide new insights into the development of HCC.
Vps4 stimulatory element of the cofactor Vta1 contacts the ATPase Vps4 alpha7 and alpha9 subunits to stimulate ATP hydrolysis.
Propose that the abscission checkpoint is mediated by ANCHR and CHMP4C through retention of VPS4 at the midbody ring.
VPS4 is required for endosomal transport of LDL cholesterol in HeLa cells.
silencing CHMP6 and VPS4A also blocked epidermal growth factor receptor (EGFR) recycling
VPS4, a master regulator of MVB sorting, may serve as a determinant of lysosomal targeting or extracellular secretion of alphaSYN and thereby contribute to the intercellular propagation of Lewy pathology in PD
These results indicate that VPS4A has a direct role in membrane scission leading to HIV-1 release.
Findings reveal new ways in which VPS4 activity is regulated and specifically directed to ESCRT-III polymers.
It was found that neither siRNA knockdown of VPS4A and VPS4B expression nor the use of cell lines that inducibly express VPS4A or VPS4B dominant negative mutants, inhibited influenza virus budding.
ESCRT-III/VPS4 proteins function at centrosomes to help regulate their maintenance or proliferation and then at midbodies during abscission, thereby helping ensure the ordered progression through the different stages of cell division.
A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization
Vps4 and the ESCRT-III complex are required for the release of infectious hepatitis C virus particles.
SKD1-dependent endosomal membrane trafficking is required for formation of autolysosomes.
CHMP4b and Alix participate in formation of multivesicular bodies by cooperating with SKD1
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16\; the gene for the other resides on chromosome 18.
vacuolar protein sorting-associated protein 4A
, vacuolar sorting protein 4
, vacuolar protein sorting 4 homolog A (S. cerevisiae)
, vacuolar protein sorting factor 4A
, vacuolar protein sorting 4a
, vacuolar protein sorting protein 4a
, vacuolar protein sorting 4 homolog A