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All Species Monoclonal TUBB3 Primary Antibody für ICC, FACS - ABIN153066
Dráberová, Lukás, Ivanyi, Viklický, Dráber: Expression of class III beta-tubulin in normal and neoplastic human tissues. in Histochemistry and cell biology 1998
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All Species Monoclonal TUBB3 Primary Antibody für ICC, FACS - ABIN93911
P?knicová, Kubátová, Sulimenko, Dráberová, Viklický, Hozák, Dráber: Differential subcellular distribution of tubulin epitopes in boar spermatozoa: recognition of class III beta-tubulin epitope in sperm tail. in Biology of reproduction 2001
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All Species Monoclonal TUBB3 Primary Antibody für ICC, FACS - ABIN269248
Zíková, Sulimenko, Dráber, Dráberová: Accumulation of 210 kDa microtubule-interacting protein in differentiating P19 embryonal carcinoma cells. in FEBS letters 2000
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All Species Monoclonal TUBB3 Primary Antibody für FACS, ICC - ABIN93912
Kukharskyy, Sulimenko, Mac?rek, Sulimenko, Dráberová, Dráber: Complexes of gamma-tubulin with nonreceptor protein tyrosine kinases Src and Fyn in differentiating P19 embryonal carcinoma cells. in Experimental cell research 2004
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Human Monoclonal TUBB3 Primary Antibody für IF - ABIN536595
Katsetos, Dráberová, Smejkalová, Reddy, Bertrand, de Chadarévian, Legido, Nissanov, Baas, Dráber: Class III beta-tubulin and gamma-tubulin are co-expressed and form complexes in human glioblastoma cells. in Neurochemical research 2007
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Human Polyclonal TUBB3 Primary Antibody für ICC, IF - ABIN151159
Rudenko, Kaganovich, Hauser, Beylina, Chia, Ding, Maric, Jaffe, Cookson: The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation. in The Biochemical journal 2012
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Broad Bean (Vicia faba) Monoclonal TUBB3 Primary Antibody für EIA, FACS - ABIN110980
Dráberová, Del Valle, Gordon, Marková, Smejkalová, Bertrand, de Chadarévian, Agamanolis, Legido, Khalili, Dráber, Katsetos: Class III beta-tubulin is constitutively coexpressed with glial fibrillary acidic protein and nestin in midgestational human fetal astrocytes: implications for phenotypic identity. in Journal of neuropathology and experimental neurology 2008
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Human Monoclonal TUBB3 Primary Antibody für IHC, IHC (p) - ABIN379991
Katsetos, Draber, Kavallaris: Targeting βIII-tubulin in glioblastoma multiforme: from cell biology and histopathology to cancer therapeutics. in Anti-cancer agents in medicinal chemistry 2012
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TUBB3 is expressed in a subgroup of colorectal neoplasms; suppression of TUBB3 potentially sensitizes neoplastic cells to taxanes
Results demonstrated that TUBB3 mutations impair the interaction of DCC with polymerized TUBB3 in MTs and inhibit netrin-1-induced neurite outgrowth, branching and attraction. These results suggest a disease mechanism underlying TUBB3 mutation-associated axon guidance defects: mutations in TUBB3 disrupt engagement of netrin/DCC signaling with MT dynamics, resulting in specific defects of netrin-1-mediated axon projection.
The remarkable high prevalence of TUBB3 expression in head and neck squamous cell carcinomas emphasizes its putative relevance as a target for future drugs targeting TUBB3
TUBB3 and TUBB4 are necessary for the transport and proper localization of N-cadherin within the plasma membrane.
The miR-34a/STMN1/betaIII-tubulin axis maintains the microtubule cytoskeleton in osteosarcoma, and combining miR-34a with microtubule inhibitors can be investigated as a novel therapeutic strategy.
Tubulin beta 3 (TUBB3) expression was identified as a useful predictive factor for survival.
This is the first study that relates concurrent expression of Tubbeta3, ZEB1, and beta-catenin to abnormal epithelial and myofibroblast differentiation in idiopathic pulmonary fibrosis, providing indirect but robust evidence of miR-200 deregulation and epithelial to mesenchymal transition activation in idiopathic pulmonary fibrosis.
The authors found that transient TUBB3 activation, through ABCB1, in response to the stimulation of FOXO3a expression, significantly contributes to the cross-resistance of the paclitaxel-resistant cell population and consequently limits the efficacy of both agents where cancer cells have developed multiple resistance.
By linkage and sequencing analyses, we identified the mutation c.784C>T (p.R262C) in TUBB3 gene in six members of a Turkish family with congenital fibrosis of the extraocular muscles.
High TUBB3 expression is associated with Melanoma.
these results identify a broad spectrum of cancers that can at least sporadically express TUBB3. Testing of TUBB3 in cancer types eligible for taxane-based therapies could be helpful to identify patients who might best benefit from this treatment.
TUBB3 overexpression is linked to an aggressive subtype of urinary bladder cancers, which is characterized by increased genetic instability, p53 alterations, and rapid cell proliferation.
The central findings of our study are that TSA and VPA affect the expression of neuronal lineage genes in an rMSCs culture. After exposure to TSA or VPA, the expression of early neuronal gene decreases but equally the expression of mature neuron genes increases
a positive correlation was observed between Snail presence and TUBB3 upregulation in tested adenocarcinoma cell lines.
This elucidates a hitherto unknown role for this microtubule protein and provides insight into correlations between high betaIII-tubulin expression and poor patient outcome in this disease
TUBB3 involvement in breast cancer cells apoptosis
The expressions of TYMS, TUBB3 and STMN1 were significantly associated with the clinicopathological characteristics of age, gender and family history of gastric cancer, but not with differentiation, growth patterns, metastasis and TNM staging in patients with gastric cancer.
It findings reveal that expression of relatively low levels of TUBB3 in mitotic cells can be detrimental for their cytokinesis and underscore the importance of CIT-K in counteracting this event.
Epitaxial growth of alpha1A/betaIII microtubules from heterogeneous brain seeds is inefficient but can be fully rescued by incorporating as little as 5% of brain tubulin into the homogeneous alpha1A/betaIII lattice.
TUBB3 mutations cause both Congenital Fibrosis of the Extraocular Muscles type 3 and malformations of cortical development.
Here, we report that dissociation of UNC5C and polymerized TUBB3, the highly dynamic beta-tubulin isoform in neurons, is essential for netrin-1/UNC5C-promoted axon repulsion. These results not only provide a working model of direct modulation of MTs by guidance cues in growth cone navigation but also help us to understand molecular mechanisms underlying developmental brain disorders associated with TUBB3 mutations.
Tubb3 could be regulated by both Akt and Erk pathways.
Results suggest that down syndrome cell adhesion molecule collaborates with deleted in colorectal cancer to regulate microtubule dynamics via direct binding to dynamic TUBB3 in Netrin-1-induced axon branching.
determined the alpha-synuclein-binding domain of beta-III tubulin and demonstrated that a short fragment containing this domain can suppress alpha-synuclein accumulation in the primary cultured cells
Study shows the critical and specific role of Tubb3 on the stereotyped morphological changes and polarization processes that are required for initiating radial migration to the cortical plate.
this study reports that TUBB3, the most dynamic beta-tubulin isoform in neurons, directly interacts with the netrin receptor DCC, and that netrin-1 induces this interaction in primary neurons.
Access to a running wheel for 48h induced plastic changes in the expression of astrocyte beta-tubulin (III). Expression was increased in the cerebellum while much smaller increases were observed in the other motor regions.
interaction between alpha-syn and beta-III tubulin plays an important role in neuronal alpha-syn accumulation in an multiple system atrophy mouse model.
Expression of Tubb3, a beta-tubulin isotype, is regulated by androgens in mouse and rat Sertoli cells.
these findings indicate that TGF-beta stimulated aberrant expression of class III beta-tubulin via activation of the ERK signaling pathway.
Endotatin can inhibit the expression of Tubulin-beta in retinal neovascularization.
High betaIII-tubulin is associated with tumorigenesis in non-small cell lung cancer.
Findings demonstrate that normal TUBB3 is required for axon guidance and maintenance in mammals.
TNF produced by activated glial cells in inflammatory or degenerative neurological diseases acts on neurites by acting on the kinesin-tubulin complex and inhibits axonal mitochondria and synaptophysin transport via JNK.
Transgenic mouse embryos overexpressing Wnt7a specifically in nestin-positive neural stem/progenitor cells displayed a delay in neuronal differentiation, assayed by beta-tubulin III expression.
A transgenic mouse class-III beta tubulin reporter using yellow fluorescent protein.
The expression of class III beta-tubulin was not related to retinal cell morphology or cell function, but rather to the cell lineage, suggesting that the expression of beta-tubulin III may be due to the retinal cell specific developmental program.
the brown phenotype in C. porcellus is caused by a loss of function of the receptor MC1R
This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6.
class III beta-tubulin
, tubulin beta-3 chain
, tubulin beta-4 chain
, tubulin beta-III
, tubulin, beta, 3
, tubulin, beta, 4
, neuron-specific class III beta-tubulin
, tubulin beta3
, beta-tubulin 3
, tubulin, beta 3
, beta3 tubulin