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Data show that RhoA is upregulated in invasive glioblastoma tissues, and its activation participates in Wnt5a (zeige WNT5A Proteine)-induced glioblastoma cell invasion.
PCGEM1 may be an inducer in epithelial ovarian cancer tumorigenesis and progression by upregulating RhoA and the subsequent expression of YAP (zeige YAP1 Proteine), P70S6K (zeige RPS6KB1 Proteine), MMP2 (zeige MMP2 Proteine), and Bcl-xL (zeige BCL2L1 Proteine).
This study identified Piezo2 mechanosensitive cationic channel as a transducer of environmental physical cues into mechanobiological responses.
High RHOA expression is associated with gastric cancer invasion and metastasis.
Results show that RHOA expression level is under the regulation of NORAD to promote EMT (zeige ITK Proteine) in pancreatic neoplasm.
Data show that phosphorylation of ribosomal protein S6 kinase 2 (RSK2 (zeige RPS6KA3 Proteine)) at threonine 577 is essential for leukemia-associated RhoGEF (LARG (zeige ARHGEF12 Proteine))-dependent Rho GTPase (zeige RACGAP1 Proteine) activation.
RhoA activated the downstream Wnt/betacatenin signaling pathway and inhibited the expression of apoptotic factors.
We identify HGF (zeige HGF Proteine), acting through the c-Met receptor, as the key polarity-inducing morphogen (zeige SHH Proteine), which acts to activate b1-integrin-dependent adhesion. HGF (zeige HGF Proteine) and ECM (zeige MMRN1 Proteine)-derived integrin signals co-operate via a c-Src (zeige SRC Proteine)-dependent inhibition of the RhoA-ROCK1 (zeige ROCK1 Proteine) signalling pathway via p190A (zeige GRLF1 Proteine) RhoGAP (zeige ARHGAP1 Proteine)
Extracellular Hsp90alpha mediates house dust mite-induced human bronchial epithelial barrier dysfunction by activating RhoA/MLC signaling, suggesting that eHsp90alpha is a potential therapeutic target for treatment of asthma.
This analysis showed a relative increase in the expression of E2F6 (zeige E2F6 Proteine) in gastric adenocarcinoma with no lymph node metastasis (chi (2), P = 0.04 and OR, P = 0.08), while overexpression of RhoA and SMUG1 (zeige SMUG1 Proteine) was found more often in the diffuse subtype of gastric adenocarcinoma as compared to the intestinal subtype.
Non-visual arrestins regulate the focal adhesion formation via small GTPases RhoA and Rac1 independently of G-protein-coupled receptors.
RHOA loss reduces YAP (zeige YAP1 Proteine) signaling of the Hippo pathway and affects YAP (zeige YAP1 Proteine) effector epiregulin (EREG (zeige EREG Proteine)) expression in the crypts. Expression of an active YAP (zeige YAP1 Proteine) (S112A) mutant rescues ntestinal stem cells (ISCs (zeige NFS1 Proteine)) marker expression, ISC regeneration, and ISC-associated Wnt (zeige WNT2 Proteine) signaling, but not defective epithelial polarity, in RhoA knockout mice, implicating YAP (zeige YAP1 Proteine) in RHOA-regulated ISC function.
GTP (zeige AK3 Proteine)-RhoA and ROCK1 (zeige ROCK1 Proteine) expression levels were markedly increased in a time-dependent manner in the ears and lungs of mice treated with penicillin.
Tyr42 phosphorylation of RhoA GTPase promotes tumorigenesis through NF-kappaB (zeige NFKB1 Proteine).
RhoA modulates the choices of molar cuspal shape by coordinating adhesion junctions, actin distribution, and fibronectin (zeige FN1 Proteine) localization to drive inner dental epithelium invagination.
Kctd13 deletion reduces synaptic transmission, which correlates with increased levels of RhoA, a KCTD13/CUL3 ubiquitin ligase substrate
Crmp4(-/-) OBs exhibited enhanced activation of RhoA/focal adhesion kinase (FAK) signaling that led to cytoskeletal changes with increased cell spreading.
Codepletion of the actomyosin regulator RhoA and Afadin results in defects in the central lumens and arrests lumen remodeling
Hydrogen peroxide oxidizes RhoA at Cys16 and Cys20, and activates RhoA via Vav2.
These results reveal a novel signaling network, the Sema4D (zeige SEMA4D Proteine)-RhoA-Akt (zeige AKT1 Proteine) signal cascade, that coordinates cellular function and morphology and highlights the importance of specific spatiotemporally restricted components of a signaling pathway in the regulation of ameloblast differentiation.
Mgc's GAP activity down-regulates the active populations of RhoA and Rac1 at localized regions of epithelial cells and is necessary for successful cytokinesis and cell-cell junction structure
Data show that shortly after anaphase onset oocytes and embryonic cells exhibit cortical waves of Rho activity and F-actin polymerization.
CASZ1/Egfl7 (zeige EGFL7 Proteine)/RhoA pathway is necessary for promoting endothelial cell behaviors associated with proper vascular assembly.
RhoA can be considered a component of the intracellular pattern formation system.
Kazrin (zeige KAZ Proteine) interacts with ARVCF (zeige ARVCF Proteine)-catenin, spectrin and p190B RhoGAP (zeige ARHGAP1 Proteine), and modulates RhoA activity.
Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements.
RhoA and membrane fluidity mediates the spatially polarized Src (zeige SRC Proteine)/FAK (zeige PTK2 Proteine) activation in response to shear stress.
the Lbc/alpha-catulin (zeige CTNNAL1 Proteine) axis participates in 5-HT (zeige DDC Proteine)-induced PASMC mitogenesis and RhoA/ROCK signaling, and may be an interventional target in diseases involving vascular smooth muscle remodeling.
The RhoA/ROCK signaling pathway is an important negative regulator of vascular calcification.
Vascular endothelial-cadherin signals through RhoA and actin cytoskeletal and affects cell-matrix adhesion
Thrombospondin has a role in inducing RhoA inactivation through FAK (zeige PTK2 Proteine)-dependent signaling to stimulate focal adhesion disassembly
KCl directly increased Rho and ROCK activities in a concentration-dependent fashion that paralleled closely the effect of KCl on lung smooth muscle tone and [Ca(2 (zeige CA2 Proteine)+)](i), as well as the voltage-dependent Ca(2 (zeige CA2 Proteine)+) currents
the Rho-ROCK signal pathway contributes to VEGF (zeige VEGFA Proteine)-induced hyperpermeability. Myosin light-chain phosphorylation and actin stress fiber formation occur concomitantly with the increase in permeability upon VEGF (zeige VEGFA Proteine) stimulation.
Formation of polygonal actin network in endothelial cells is a novel rhoA associated response to hypertonic stress.
Cadherins, RhoA and Rac1, have important roles in mechanotransduction and that endothelial and smooth muscle cells use different mechanisms to respond to stretch.
Results indicate that hypergravity induces ATP release and actin reorganization via RhoA activation and FAK (zeige PTK2 Proteine) phosphorylation, thereby activating cell proliferation and migration in bovine aortic endothelial cells.
Pseudorabies virus US3 expression led to RhoA phosphorylation at serine 188 to induce actin rearrangements.
Data indicate that TNF-alpha (zeige TNF Proteine) stimulates Rac (zeige AKT1 Proteine), ADAM17/TACE (zeige ADAM17 Proteine), and RhoA through the guanine nucleotide exchange factor (zeige ARHGEF12 Proteine) (GEF)-H1 (zeige ARHGEF2 Proteine).
Contractile pulmonary arterial myocytes exhibit marked Rho-dependent actin polymerization in hypoxia, with increased active RhoA and LIMK (zeige LIMK1 Proteine) phosphorylation.
Results suggest that Rac1 and RhoA are regulated by TGFbeta1 (zeige TGFB1 Proteine) in the process of endothelial tube formation in collagen I gels.
The concentration of RhoA mRNA and activated RhoA enzyme were greater in urothelium than in detrusor. Rho kinase (zeige ROCK1 Proteine) inhibitor Y-27632 showed a stronger inhibitory effect in detrusor with intact urothelium.
Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.
Activating Rho could be beneficial to suppress Kras mutant-induced liver malignancies.
Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton.
Aplysia ras-related homolog 12
, oncogene RHO H12
, ras homolog gene family, member A
, rho cDNA clone 12
, small GTP binding protein RhoA
, transforming protein RhoA
, Rho-related protein HP1
, ras homolog D
, ras homolog gene family, member D
, rho-related GTP-binding protein RhoD
, Ras family member A
, Rho family GTPase
, aplysia ras-related homolog A
, aplysia ras-related homolog A1
, aplysia ras-related homolog A2
, ras homolog A1
, ras homolog A2
, ras homolog gene family, member A1
, ras homolog gene family, member A2
, plysia ras-related homolog A2
, rho1 GTP-binding protein
, RhoA GTPase
, Rho A