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Taken together, our results suggest that SGK1 inhibits PM2.5-induced cell apoptosis and ROS (zeige ROS1 Proteine) generation via ERK1/2 and AKT (zeige AKT1 Proteine) signaling pathway in human lung alveolar epithelial A549cells.
High SGK1 expression is associated with gastric cancer.
SGK1 was found to be essential for proliferation and survival of thyroid cancer cells harboring PI3K (zeige PIK3CA Proteine)-activating mutations.
miRNA-7-5p can regulate the expression of human alveolar ENaC (zeige SCNN1A Proteine) by targeting the mTORC2 (zeige CRTC2 Proteine)/SGK-1 signaling pathway.
TLR4 (zeige TLR4 Proteine) and C5aR (zeige C5AR1 Proteine) crosstalk in dendritic cells induces a core regulatory network of RSK2 (zeige RPS6KA3 Proteine), PI3Kbeta, SGK1, and FOXO (zeige FOXO3 Proteine) transcription factors.
Findings illustrate how cancer cells utilize a chromatin remodeling factor (zeige ASH1L Proteine) to engage a core survival pathway to support its cancerous phenotypes, and reveal new facets of MTA1 (zeige MTA1 Proteine)-SGK1 axis by a physiologic signal in cancer progression.
SGK1 inhibitor SI113 induced a significant reduction in endometrial cancer cells viability, as a result of induction of autophagy, apoptosis, and endoplasmic reticulum stress.
Findings show that serum and glucocorticoid-inducible kinase 1 (SGK1) protein dynamics can be an important part of intracellular signaling, directly influencing cellular response decisions.
In cancer cells resistant to PI3Kalpha inhibition, PDK1 blockade restores sensitivity to these therapies. SGK1, which is activated by PDK1, contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2.
SGK1 promotes YAP/TAZ transcriptional activity. SGK1 enhances YAP/TAZ activity by upregulating YAP/TAZ. SGK1 is a transcriptional target of YAP. SGK1 stabilizes TAZ by inhibiting GSK3beta.
Experiments showed a dynamic change of immune inflammation, oxidative stress and p38MAPK (zeige MAPK14 Proteine)-SGK1 pathway involvement in EAE demonstrating that p38MAPK (zeige MAPK14 Proteine)-SGK1 pathway and oxidative stress contribute to the demyelination in central nerve system caused by Th17 inflammatory responses in a synergistic way.
SGK1 was found to be essential for proliferation and survival of thyroid cancer cells harboring PI3K-activating mutations.
Altered K balance in animals lacking SGK1 may reflect defects in epithelial Na channel -independent K excretion
our data suggest that renal tubular SGK1 is important in the regulation of K(+) excretion via the control of NEDD4-2 (zeige NEDD4L Proteine), WNK1 (zeige WNK1 Proteine), and ENaC (zeige SCNN1A Proteine)
SGK1 is similarly involved in the regulation of cell volume and cell fluid transport.
Mineralocorticoid receptor (zeige NR3C2 Proteine) deficiency suppresses migration and proliferation of macrophages and leads to less vascular smooth muscle cell activation. At the molecular level, MR deficiency suppresses macrophage inflammatory response via SGK1-AP1 (zeige JUN Proteine)/NF-kappaB (zeige NFKB1 Proteine) pathways.
Akt3 (zeige AKT3 Proteine) constitutively suppresses macropinocytosis in macrophages through a novel WNK1 (zeige WNK1 Proteine)/SGK1/Cdc42 (zeige CDC42 Proteine) pathway.
SGK1 and SGK3 (zeige SGK3 Proteine) are expressed in multiple microglial cell lines. SGK1 and SGK3 (zeige SGK3 Proteine) may play an important role in regulating microglial viability and inflammatory responses.
The data indicate that the balanced activities of two related serine/threonine kinases, AKT (zeige AKT1 Proteine) and SGK1, critically govern the embryo implantation process.
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Sgk1 variant i3
, serine/threonine protein kinase SGK
, serine/threonine-protein kinase Sgk1
, serum/glucocorticoid-regulated kinase 1
, serum and glucocorticoid-dependent protein kinase
, serum/glucocorticoid regulatory kinase
, serum- and glucocorticoid-induced kinase
, serum and glucocorticoid-regulated protein kinase