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The findings support a model in which survival is determined by quantitative participation of multiple anti-apoptotic proteins, BCL2 (zeige BCL2 Proteine), Mcl1, and BCL2A1 (zeige BCL2A1 Proteine), rather than by a single anti-apoptotic protein.
This dynamic change in B cell survival mechanisms is unique to Epstein-Barr virus-infected cells and relies on regulation of MCL-1 mitochondrial localization and BFL-1 transcription by the viral EBNA3A protein.
Overexpression of Mcl-1 via the hemopoietic cell specific vavP-Mcl-1 transgene markedly exacerbates and accelerates the lpr (zeige FAS Proteine) phenotype. The progressive splenomegaly and lymphadenopathy displayed by lpr (zeige FAS Proteine) mice was far more severe in Mcl (zeige CLEC4D Proteine)-1tg/lpr (zeige FAS Proteine) littermates
Endothelial cell -specific deletion of Mcl1 resulted in a dose-dependent increase in endothelial cell apoptosis in the angiogenic vasculature and a corresponding decline in vessel density.
Our findings indicate that MCL-1 expression is an important biomarker of TEC survival
These results identify MCL-1 as a critical prosurvival protein for preventing beta-cell death and clarify the mechanisms behind its downregulation by proinflammatory cytokines.
These data show that Mcl-1 is dispensable for the regulation of apoptosis during infection with different large DNA viruses.Bcl-XL, on the other hand, can be important to maintain survival of virus-infected cells
BCL-XL (zeige BCL2L1 Proteine) expression promotes survival of immature B cells, expression of BCL-2 (zeige BCL2 Proteine) is important for survival of mature B cells and long-lived plasma cells (PC), and expression of MCL-1 is important for survival throughout B-cell development.
miR (zeige MLXIP Proteine)-32/MCL-1 pathway members were identified as key early genetic events driving melanoma progression.
GSK3B-MCL1 signaling to regulate axonal autophagy might be important for the successful completion of Wallerian degeneration.
Deubiquitinating enzyme 13 (USP13 (zeige USP13 Proteine)) regulates myeloid cell leukemia sequence 1 protein (MCL1) stability in lung and ovarian cancer cells.
High MCL1 expression is associated with renal cell carcinoma (zeige MOK Proteine).
Our studies not only define the essential role of Mcl-1 in chemoresistance, but also for the first time link a key pro-survival Bcl-2 (zeige BCL2 Proteine) family member with the NOX protein family, both of which have significant ramifications in cancer progression.
Co-treatment with inhibitors to Mcl-1, PI3K (zeige PIK3CA Proteine), RAF (zeige RAF1 Proteine) or MEK (zeige MAP2K1 Proteine) restores mTOR (zeige FRAP1 Proteine) inhibitor-induced apoptosis by antagonizing Mcl-1 or abrogating ERK (zeige EPHB2 Proteine) activation in BRAFV600E cells.
Together, these data suggest that Mcl-1 is a major contributor to BET inhibitor-resistance in HCC (zeige FAM126A Proteine) cells, and that combining drugs capable of down-regulating Mcl-1 may promote therapeutic potential in human HCC (zeige FAM126A Proteine).
Report the complexity in Mcl-1 phosphorylation/degradation in response to microtubule targeting agents in Hela cells.
Data suggest that FBXW7, MCL1 and PLK1 may be relevant predictive markers of tumor progression and response to paclitaxel treatment.
Synthesis of MCL1, an antiapoptotic protein known to play a role in cancer cell survival during cell division, depends on the function of MELK (zeige MELK Proteine)-elF4B signaling.
Immunohistochemical analysis showed that the MCL-1 positive rate among myelodysplastic syndromes (MDSs) bone marrow CD34 (zeige CD34 Proteine) positive cells significantly increased during transformation to overt leukaemia (OL). Additionally, MCL-1 positive cells were negative for cleaved caspase 3 (zeige CASP3 Proteine), which indicated that these cells avoided apoptosis.
sequestration of Bim (zeige BCL2L11 Proteine) by Mcl-1 is a mechanism of intrinsic ABT-199 resistance and supports the clinical development of ABT-199 in combination with cytarabine or daunorubicin for the treatment of AML (zeige RUNX1 Proteine).
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.
bcl-2-related protein EAT/mcl1
, induced myeloid leukemia cell differentiation protein Mcl-1 homolog
, bcl-2-like protein 3
, induced myeloid leukemia cell differentiation protein Mcl-1
, myeloid cell leukemia ES
, myeloid cell leukemia protein 1