anti-Human BAD Antikörper für Dot Blot

Recommended BAD Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
BCL2-Associated Agonist of Cell Death (BAD) Antikörper
  • bad
  • fa01b12
  • wu:fa01b12
  • wu:fa96d04
  • BAD
  • BBC2
  • BCL2L8
  • AI325008
  • Bbc2
  • BCL2-associated agonist of cell death b
  • BCL2 associated agonist of cell death
  • BCL2-associated agonist of cell death
  • badb
  • BAD
  • Bad
Epitop
pSer99
60
58
53
49
47
46
42
39
29
22
22
20
20
20
20
20
20
20
20
20
20
20
20
20
20
19
19
19
19
18
18
15
15
12
10
9
8
7
7
5
5
5
5
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
779
450
276
19
15
8
5
4
3
2
2
1
1
1
1
1
1
Wirt
Kaninchen
997
49
2
1
Klonalität
Polyklonal
Konjugat
Dieser BAD Antikörper ist unkonjugiert
67
66
66
60
60
60
6
6
6
6
6
6
6
6
6
6
6
2
2
2
2
2
2
2
2
2
2
2
Applikation
Dot Blot (DB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
538
507
404
296
122
79
53
30
13
13
6
5
4
3
2
1
1
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN389521
$ 324.50
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
28.901054 ABIN1539690 DB Rabbit Ig pSer1159 Anmelden zum Anzeigen Polyclonal 1
28.901054 ABIN1539741 DB Rabbit Ig pTyr158 Anmelden zum Anzeigen Polyclonal 1
28.901054 ABIN1539706 DB Rabbit Ig AA 41-70, pSer64 Anmelden zum Anzeigen Polyclonal 0
28.901054 ABIN1539737 DB Rabbit Ig pTyr110 Anmelden zum Anzeigen Polyclonal 0
28.901054 ABIN1539722 DB Rabbit Ig pThr137 Anmelden zum Anzeigen Polyclonal 0
28.901054 ABIN1539776 DB Rabbit Ig pSer74 Anmelden zum Anzeigen Polyclonal 0
28.901054 ABIN1539773 DB Rabbit Ig pSer71 Anmelden zum Anzeigen Polyclonal 0
28.901054 ABIN1539757 DB Rabbit Ig pSer1041 Anmelden zum Anzeigen Polyclonal 0
28.901054 ABIN1539717 DB Rabbit Ig pSer91 Anmelden zum Anzeigen Polyclonal 0
28.901054 ABIN1539752 DB Rabbit Ig pTyr76 Anmelden zum Anzeigen Polyclonal 0
28.901054 ABIN1539698 DB Rabbit Ig pSer25 Anmelden zum Anzeigen Polyclonal 0
28.901054 ABIN1881098 DB Rabbit pSer124 Anmelden zum Anzeigen Polyclonal 2
28.901054 ABIN1881099 DB Rabbit pSer32 Anmelden zum Anzeigen Polyclonal 2
28.901054 ABIN1881100 DB Rabbit pThr80 Anmelden zum Anzeigen Polyclonal 2
28.901054 ABIN1881101 DB Rabbit pSer57 Anmelden zum Anzeigen Polyclonal 2
28.901054 ABIN3030133 DB ELISA Rabbit Ig Fraction pTyr110 Anmelden zum Anzeigen Polyclonal 0
28.901054 ABIN3030130 DB IF IHC ELISA Rabbit Ig Fraction pSer99 Anmelden zum Anzeigen Polyclonal 0
28.901054 ABIN3030131 DB ELISA Rabbit Ig Fraction pThr137 Anmelden zum Anzeigen Polyclonal 0
28.901054 ABIN3030119 DB ELISA Rabbit Ig Fraction pSer124 Anmelden zum Anzeigen Polyclonal 0
28.901054 ABIN3030126 DB ELISA Rabbit Ig Fraction pSer71 Anmelden zum Anzeigen Polyclonal 0

General

Antigen BCL2-Associated Agonist of Cell Death (BAD) Antikörper
Epitop pSer99
(60), (58), (53), (49), (47), (46), (42), (39), (29), (22), (22), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (19), (19), (19), (19), (18), (18), (15), (15), (12), (10), (9), (8), (7), (7), (5), (5), (5), (5), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human
(779), (450), (276), (19), (15), (8), (5), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Wirt Kaninchen
(997), (49), (2), (1)
Klonalität (Klon)
Polyklonal   ( )
Konjugat Dieser BAD Antikörper ist unkonjugiert
(67), (66), (66), (60), (60), (60), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Applikation Dot Blot (DB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(538), (507), (404), (296), (122), (79), (53), (30), (13), (13), (6), (5), (4), (3), (2), (1), (1), (1)
Pubmed 2 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-BAD Antikörper

Target Details BAD Anwendungsinformationen Handhabung Referenzen für anti-BAD Antikörper (ABIN389521) Bilder
Homologie Mouse (Murine),Rat (Rattus)
Reinigung This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen This Bad Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S99 of human Bad.
Klon RB06933
Isotyp Ig Fraction

Target Details BAD

Produktdetails anti-BAD Antikörper Anwendungsinformationen Handhabung Referenzen für anti-BAD Antikörper (ABIN389521) Bilder zurück nach oben
Antigen
Andere Bezeichnung Bad (BAD Antibody Abstract)
Hintergrund Bad is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin are found to be involved in the regulation of this protein. Bad is phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation.

Synonyms: Bcl2-antagonist of cell death, BAD, Bcl-2 binding component 6, Bcl-XL/Bcl-2-associated death promoter, Bcl-2-like 8 protein, BAD, BBC6, BCL2L8,
Pathways: Neurotrophin signaling pathway, Hepatitis C, Insulin signaling pathway, Alzheimer's disease, VEGF signaling pathway, Toxoplasmosis, Pathways in cancer, Non-small cell lung cancer, Tuberculosis, Focal adhesion, Prostate cancer, Melanoma, Apoptosis, Colorectal cancer, Pancreatic cancer, ErbB signaling pathway, Chronic myeloid leukemia, Endometrial cancer, Acute myeloid leukemia, Amyotrophic lateral sclerosis (ALS)
Molekulargewicht 18392 Da
Gen-ID 572
UniProt Q92934
Pathways MAPK Signalweg, PI3K-Akt Signalweg, RTK Signalweg, Apoptose, Fc-epsilon Rezeptor Signalübertragung, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Hepatitis C, CXCR4-mediated Signaling Events

Anwendungsinformationen

Produktdetails anti-BAD Antikörper Target Details BAD Handhabung Referenzen für anti-BAD Antikörper (ABIN389521) Bilder zurück nach oben
Applikationshinweise Suggested dilutions:
IF = 1:200, DB = 1:500, IHC (p) = 1:50-100
Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-BAD Antikörper Target Details BAD Anwendungsinformationen Referenzen für anti-BAD Antikörper (ABIN389521) Bilder zurück nach oben
Format Liquid
Konzentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handhabung Avoid freeze-thaw cycles.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
Haltbarkeit 6 months

Referenzen für anti-BAD Antikörper (ABIN389521)

Produktdetails anti-BAD Antikörper Target Details BAD Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Hurbin, Coll, Dubrez-Daloz, Mari, Auberger, Brambilla, Favrot: "Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells." in: The Journal of biological chemistry, Vol. 280, Issue 20, pp. 19757-67, 2005

Antignani, Youle: "A chimeric protein induces tumor cell apoptosis by delivering the human Bcl-2 family BH3-only protein Bad." in: Biochemistry, Vol. 44, Issue 10, pp. 4074-82, 2005

Bilder

Produktdetails anti-BAD Antikörper Target Details BAD Anwendungsinformationen Handhabung Referenzen für anti-BAD Antikörper (ABIN389521) zurück nach oben
Bilder des Herstellers
Dot Blot (DB) image for anti-BCL2-Associated Agonist of Cell Death (BAD) (pSer99) antibody (ABIN389521) Dot blot analysis of anti-hBad-pS99 Phospho-specific Pab (ABIN389521) on nitrocellulo...
Immunohistochemistry (IHC) image for anti-BCL2-Associated Agonist of Cell Death (BAD) (pSer99) antibody (ABIN389521) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...