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Human EZR Protein expressed in HEK-293 Cells - ABIN2720647
Miyaji, Shahrizaila, Umapathi, Chan, Hirata, Yuki: Are ERM (ezrin/radixin/moesin) proteins targets for autoantibodies in demyelinating neuropathies? in Human immunology 2015
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Ezrin-anchored PKA phosphorylates serine 369 and 373 on connexin 43 (zeige GJA1 Proteine) to enhance gap junction assembly, communication, and cell fusion.
High Ezrin expression is associated with osteosarcoma.
L1CAM (zeige L1CAM Proteine) promotes esophageal squamous cell carcinoma tumorigenicity by upregulating ezrin expression.
This is the first study to verify the relationship of the expression of RhoA (zeige RHOA Proteine) and Ezrin proteins in vaginal tissue of Postmenopausal atrophic vagina.
ezrin facilitates AQP2 (zeige AQP2 Proteine) endocytosis, thus linking the dynamic actin cytoskeleton network with AQP2 (zeige AQP2 Proteine) trafficking.
FUT4/LeY was critical to the TAMs-mediated EMT; this process might be associated with the up-regulation of Ezrin phosphorylation by FUT4/LeY-mediated fucosylation
CPI-17 (zeige PPP1R14A Proteine) drives Ras activity and tumorigenesis in melanomas in a two-fold way; inactivation of the tumor suppressor merlin (zeige NF2 Proteine) and activation of the growth promoting ERM (zeige ETV5 Proteine) family.
Data suggest that EGF (zeige EGF Proteine) induces colorectal cancer cells to undergo epithelial-mesenchymal transition, enhances their ability to invade/migrate, and promotes phosphorylation of Ezrin at Tyr353. (EGF (zeige EGF Proteine) = epidermal growth factor (zeige EGF Proteine))
Binding of phosphatidylinositol 4,5-biphosphate to ezrin induces a conformational change permitting the insertion of the LOK C-terminal domain to wedge apart the membrane and F-actin-binding domains of ezrin. The N-terminal LOK kinase domain can then access a site 40 residues distal from the consensus sequence that collectively direct phosphorylation of the appropriate threonine residue.
The expression pattern and subcellular localization of ezrin and moesin (zeige MSN Proteine) correlate with clinicopathological variables such as patients' age, tumor grade and hormonal status.
Data suggest that Mst4 (zeige MST4 Proteine) phosphorylation of Thr545 of Acap4/Asap3 (zeige ASAP3 Proteine) in parietal cells leads to Acap4/Asap3 (zeige ASAP3 Proteine) binding to Ser66-phosphorylated ezrin (a cytoskeletal protein (zeige ACTN1 Proteine)); phosphorylation of Thr545 of Acap4/Asap3 (zeige ASAP3 Proteine) is required for relocation of H,K-ATPase (zeige ATP1A1 Proteine) to apical plasma membrane and acid secretion by parietal cells. (Mst4 (zeige MST4 Proteine) = serine/threonine-protein kinase Mst4 (zeige MST4 Proteine); Acap4/Asap3 (zeige ASAP3 Proteine) = GTPase-activating protein (zeige RASA1 Proteine) Acap4/Asap3 (zeige ASAP3 Proteine))
Spatial control of proton pump H,K-ATPase (zeige ATP1A1 Proteine) docking at the apical membrane by phosphorylation-coupled ezrin-syntaxin 3 (zeige STX3 Proteine) interaction.
1) NHE3 (zeige SLC9A3 Proteine) basal activity is regulated by a signaling complex that is controlled by sequential effects of two kinases, Akt (zeige AKT1 Proteine) and GSK-3, which act on a Ser (zeige SIGLEC1 Proteine) cluster in the same NHE3 (zeige SLC9A3 Proteine) C-terminal domain that binds ezrin
Ezrin-mediated F-actin interaction with the epithelial cell may direct membrane recruitment and cytoskeletal surface extension.
relatively high turnover of ezrin T567 phosphorylation was observed in all three epithelia (gastric, kidney and intestine).
Ezrin and CK18 (zeige KRT18 Proteine) are downregulated during implantation in cattle. The expression changes represent a temporal depolarization, which could be important for an establishment of bovine pregnancy.
Ezrin-dependent, membrane-specific translocation and activation of calpain by VEGF (zeige VEGFA Proteine) precedes AMPK (zeige PRKAA1 Proteine) and AKT (zeige AKT1 Proteine)-dependent phosphorylation of eNOSs1179 and production of NO.
Ezrin level may serve as a differential diagnostic and/or prognostic biomarker for high and low lymphatic metastasis -Hepatocellular carcinoma (HCC (zeige FAM126A Proteine))and may be beneficial in the diagnosis of HCC (zeige FAM126A Proteine) disease
Inactivation of SHIP2 (zeige INPPL1 Proteine) leads to increased microvilli formation and solute reabsorption by the renal proximal tubule and was associated with hyperactivated ezrin/radixin/moesin (zeige MSN Proteine) proteins and increased Rho-GTP (zeige AK3 Proteine).
high actin-ezrin intensity area restricts the lateral movement of B cell receptors upon stimulation, reducing receptor clustering and signaling
Ezrin may play a role in regulating lymphatic metastasis in hepatocellular carcinoma and might be inversely associated with A7 expression.
Augmented hypertension-induced glomerular capillary injury in mice lacking CLIC5 results from abrogation of Rac1-dependent Pak and ezrin activation, perhaps reducing the tensile strength of the podocyte actin cytoskeleton.
Data, including data from studies in knockout mice, suggest that VDR (vitamin D receptor) regulates expression of ezrin in enterocytes; VDR appears not to be involved in morphology of tight junctions and absorption of large molecules in enterocytes.
Lack of ezrin not only causes achlorhydria and hypergastrinemia but also changes the structure of gastric glands, with severe perturbation of the secretory membranes of parietal cells.
our study demonstrates that ezrin is a novel regulator of IL-10 (zeige IL10 Proteine) production by B cells
Merlin (zeige NF2 Proteine) and Ezrin are components of a mechanism where mechanical forces associated with cell junctions are transduced across the cell cortex via cortical actomyosin cytoskeleton to control lateral mobility and activity of epidermal growth factor receptor (zeige EGFR Proteine).
Dysfunction of ezrin mimics important aspects of the pathological mechanisms responsible for cholangiopathies
The cytoskeletal linker protein (zeige LAT Proteine) ezrin plays a significant role in hypothermic preservation injury in renal epithelia.
Coexpression of ezrin with Eps8 promotes the formation of membrane ruffles and tufts of microvilli, whereas expression of ezrin and Eps8L1a induces the clustering of actin-containing structures at the cell surface.
These findings reveal that direct ezrin interactions promote PTH1R apical localization and signaling in LLC-PK1 cells.
ELMO-DOCK1 (zeige DOCK1 Proteine), a bipartite guanine nucleotide exchange factor (zeige ARHGEF12 Proteine) complex for the small GTPase (zeige RACGAP1 Proteine) Rac1, and for the membrane-cytoskeletal linker Ezrin, regulates centriole/basal body migration, docking and spacing.
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.
, villin 2 (ezrin)
, villin 2
, ezrin L homeolog
, ezrin S homeolog