anti-Human IL15 Antikörper für Functional Studies

Recommended IL15 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Interleukin 15 (IL15) Antikörper
  • IL15
  • AI503618
  • IL-15
  • interleukin 15
  • IL15
  • Il15
Reaktivität
Human
228
68
26
10
8
6
5
2
2
1
1
1
Wirt
Maus
150
123
18
17
5
5
Klonalität
Monoklonal
Konjugat
Dieser IL15 Antikörper ist unkonjugiert
38
17
11
9
9
5
5
5
5
5
4
3
3
3
3
3
3
3
2
2
2
1
1
Applikation
Functional Studies (Func), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP)
214
189
65
33
32
27
22
16
13
11
9
7
5
4
3
3
3
2
1
1
1
1
1
1
1
1
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Bilder

Produktnummer ABIN2665113
Preis und Verfügbarkeit auf Anfrage.
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN1107803 Func Mouse IgG1 Anmelden zum Anzeigen B-E29 4
1 ABIN2474939 Func IHC (p) IP ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 2
1 ABIN2665112 Func ICC FACS IP Mouse IgG1 kappa Anmelden zum Anzeigen BH1509 9
1 ABIN116111 EIA Func IHC (p) WB Rabbit Anmelden zum Anzeigen Polyclonal 0
1 ABIN116112 EIA Func IHC (p) WB Rabbit Anmelden zum Anzeigen Polyclonal 0
1 ABIN1724573 Func FACS ELISA Mouse IgG1 Anmelden zum Anzeigen B-E29 0
1 ABIN640561 Func IP ELISA WB Rabbit Anmelden zum Anzeigen 0

General

Antigen Interleukin 15 (IL15) Antikörper
Reaktivität Human
(228), (68), (26), (10), (8), (6), (5), (2), (2), (1), (1), (1)
Wirt Maus
(150), (123), (18), (17), (5), (5)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser IL15 Antikörper ist unkonjugiert
(38), (17), (11), (9), (9), (5), (5), (5), (5), (5), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1)
Applikation Functional Studies (Func), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP)
(214), (189), (65), (33), (32), (27), (22), (16), (13), (11), (9), (7), (5), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 9 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-IL15 Antikörper

Target Details IL15 Anwendungsinformationen Handhabung Referenzen für anti-IL15 Antikörper (ABIN2665113) Bilder
Reinigung The antibody was purified by affinity chromatography.
Klon BH1509
Isotyp IgG1 kappa

Target Details IL15

Produktdetails anti-IL15 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-IL15 Antikörper (ABIN2665113) Bilder zurück nach oben
Antigen
Andere Bezeichnung IL-15 (IL15 Antibody Abstract)
Hintergrund Interleukin-15 (IL-15) was discovered in supernatant from simian kidney epithelial cell line CV-1/EBNA, as a soluble factor capable of supporting proliferation of the IL-2-dependent cell line, CTLL-2 (1). IL-15 is a regulatory cytokine that is produced by dendritic cells, epithelial cells, human stromal cell line (IMTLH), fibroblasts, and monocytes (2). It plays an important role in immune response and shares many functions with IL-2, for example, it stimulates the proliferation of activated T cells (1, 2), NK cells (3) and B cells, and it induces immunoglobulin synthesis by B cells stimulated by anti-IgM or CD40 ligand (4). In addition, IL-15 promotes the development of dendritic cells (5), activates human neutrophils (6, 7) and induces the production of proinflammatory cytokines from macrophages (8). IL-15 acts as a bridge between innate and adaptive immunity because of its diverse roles in the immune system. IL-15 binds to heterotrimeric receptors composed of IL-15Rα, IL-15Rβ, and IL-15Rγc. IL-15 shares with IL-2 the receptor chains β and γc. IL-15 is normally not secreted in soluble form but is held on the cell surface bound to a unique receptor, IL-15Rα, especially on dendritic cells. Cell-bound IL-15 then is presented in trans to T cells and NK cells and is recognized by the γc receptor on these cells, such recognition maintains cell survival and intermittent proliferation (9).
Pathways JAK-STAT Signalweg, Glycosaminoglycan Metabolic Process

Anwendungsinformationen

Produktdetails anti-IL15 Antikörper Target Details IL15 Handhabung Referenzen für anti-IL15 Antikörper (ABIN2665113) Bilder zurück nach oben
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-IL15 Antikörper Target Details IL15 Anwendungsinformationen Referenzen für anti-IL15 Antikörper (ABIN2665113) Bilder zurück nach oben
Konzentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung The antibody solution should be stored undiluted between 2°C and 8°C.

Referenzen für anti-IL15 Antikörper (ABIN2665113)

Produktdetails anti-IL15 Antikörper Target Details IL15 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Tang, Zhao, Jiang, Ba, Cui, He: "Activity of recombinant human interleukin-15 against tumor recurrence and metastasis in mice." in: Cellular & molecular immunology, Vol. 5, Issue 3, pp. 189-96, 2008

Rubinstein, Kovar, Purton, Cho, Boyman, Surh, Sprent: "Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 24, pp. 9166-71, 2006

Ma, Koka, Burkett: "Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis." in: Annual review of immunology, Vol. 24, pp. 657-79, 2006

Bouchard, Ratthé, Girard: "Interleukin-15 delays human neutrophil apoptosis by intracellular events and not via extracellular factors: role of Mcl-1 and decreased activity of caspase-3 and caspase-8." in: Journal of leukocyte biology, Vol. 75, Issue 5, pp. 893-900, 2004

Meresse, Chen, Ciszewski, Tretiakova, Bhagat, Krausz, Raulet, Lanier, Groh, Spies, Ebert, Green, Jabri: "Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease." in: Immunity, Vol. 21, Issue 3, pp. 357-66, 2004

Pulendran, Dillon, Joseph, Curiel, Banchereau, Mohamadzadeh: "Dendritic cells generated in the presence of GM-CSF plus IL-15 prime potent CD8+ Tc1 responses in vivo." in: European journal of immunology, Vol. 34, Issue 1, pp. 66-73, 2004

Ratthé, Girard: "Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain." in: Journal of leukocyte biology, Vol. 76, Issue 1, pp. 162-8, 2004

Armitage, Macduff, Eisenman, Paxton, Grabstein: "IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 2, pp. 483-90, 1995

Grabstein, Eisenman, Shanebeck, Rauch, Srinivasan, Fung, Beers, Richardson, Schoenborn, Ahdieh: "Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor." in: Science (New York, N.Y.), Vol. 264, Issue 5161, pp. 965-8, 1994

Bilder

Produktdetails anti-IL15 Antikörper Target Details IL15 Anwendungsinformationen Handhabung Referenzen für anti-IL15 Antikörper (ABIN2665113) zurück nach oben
Bilder des Herstellers
ELISA image for anti-Interleukin 15 (IL15) antibody (ABIN2665113) anti-Interleukin 15 (IL15) antibody