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Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN803868
Pacheco, Oliva, Martinez-Navío, Climent, Ciruela, Gatell, Gallart, Mallol, Lluis, Franco: Glutamate released by dendritic cells as a novel modulator of T cell activation. in Journal of immunology (Baltimore, Md. : 1950) 2006
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Rat (Rattus) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305130
McKnight, Barclay, Mason: Molecular cloning of rat interleukin 4 cDNA and analysis of the cytokine repertoire of subsets of CD4+ T cells. in European journal of immunology 1991
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Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305126
Paul: Interleukin-4: a prototypic immunoregulatory lymphokine. in Blood 1991
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Mouse (Murine) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1305127
Noma, Sideras, Naito, Bergstedt-Lindquist, Azuma, Severinson, Tanabe, Kinashi, Matsuda, Yaoita: Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter. in Nature 1986
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Mouse (Murine) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN1888633
Osusky, Teschke, Wang, Wong, Buckley: A chimera of interleukin 2 and a binding variant of aerolysin is selectively toxic to cells displaying the interleukin 2 receptor. in The Journal of biological chemistry 2008
Human IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN2004839
Tao, Yang, Jia, Wan, Cheng, Lu: Molecular cloning, recombinant expression and characterization of GMCSF from the rhesus monkey, Macaca mulatta. in Developmental and comparative immunology 2013
Human IL-4 Protein expressed in HEK-293 Cells - ABIN2181318
Finkelman, Shea-Donohue, Morris, Gildea, Strait, Madden, Schopf, Urban: Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites. in Immunological reviews 2004
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Mouse (Murine) IL-4 Protein expressed in Escherichia coli (E. coli) - ABIN804054
Pacheco, Martinez-Navio, Lejeune, Climent, Oliva, Gatell, Gallart, Mallol, Lluis, Franco: CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse. in Proceedings of the National Academy of Sciences of the United States of America 2005
IL-33 has a role in the pathogenesis of autoimmune hepatitis (AIH) and affects the expression of IL-4, IL-17A, and of hypergammaglobulinemia
Interleukin-4 induces a CD44high /CD49bhigh PC3 subpopulation with tumor-initiating characteristics.
Allelic polymorphism C590T of the gene IL-4 is the most possible genetic marker of high predisposition to development of recurrent episodes of acute obstructive bronchitis in children.
certain single nucleotide polymorphisms of IL4 gene could predispose individuals to recurrent aphthous stomatitis
results suggest, the interplay of pro-inflammatory cytokines IFN-gamma derived from CD4+T lymphocytes and TNF-alpha from CD14+ cells has no direct additive impact on parasite replication but induces IL-4 production.
Germline variants in IL4 gene are associated with prostate cancer.
The role of IL-4 in psoriasis.
serum IP-10 level and the IFN-gamma/IL-4 ratio have great potential to predict significant fibrosis among chronic hepatitis B patients.
By establishing that IL-4 is posttranslationally regulated by TRX-promoted reduction of a disulfide bond, our findings highlight a novel regulatory mechanism of the type 2 immune response that is specific to IL-4 over IL-13.
IL-4 polymorphisms might be associated with Kawasaki disease in an Iranian population.
association between root resorption and IL4 gene polymorphisms was observed.
these results demonstrated that variable number tandem repeat polymorphism in the IL-4 gene is associated with diabetic peripheral neuropathy in type 2 diabetes patients with coexisting cardiovascular disease
serum antibodies against HP-NAP represent a state of risk, which is further exacerbated in IL-4 -590 T carriers.
Polymorphisms at IL10 (-1082 G>A), IL4 (-589 C>T), CTLA4 (+49A>G), and DAO (+8956 C>G) genes were studied in 55 cases.
Defective sirtuin-1 was found to increase IL-4 expression through acetylation of GATA-3 in patients with severe asthma compared with healthy controls.
The results confirmed that the IL-4-590C/T polymorphism is correlated with the onset of RA and that carrying the T-allele can significantly increase the risk of rheumatoid arthritis in the Chinese Han population.
the IL-4-590 C>T polymorphism does not influence the development of head and neck cancer.
the present study suggests that IL-4 polymorphisms might play a role in susceptibility to inflammatory bowel disease and its major subtypes in the Iranian population
IL-4R plays an important role in regulating hepatocellular carcinoma (HCC)cell survival and metastasis, and regulates the activity of the JAK1/STAT6 and JNK/ERK1/2 signaling pathways. We therefore suggest that IL-4/IL-4R may be a new therapeutic target for HCC
IL-4 rs2227288 and IL-10 rs1800872 may contribute to an increased risk for virus-induced encephalitis. Through use of direct sequencing, we showed that genotypes of IL-4 rs2227288 and IL-10 rs1800872 may have particular host susceptibility to virus-induced encephalitis. IL-4 rs2227283 and IL-10 rs1800871 have no correlation in with risk of virus-induced encephalitis (both P>0.05)
Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity.
Ndfip1 preserves Treg lineage stability and immune homeostasis by preventing the expansion of highly proliferative and metabolically active Treg cells and by preventing pathological secretion of IL-4 from Treg cells
IL-4/ STAT6 signaling needs to be well adjusted to ensure proper development and function of homing Th2 cells.
The VEGFR1-mediated signaling suppressed IL-4-induced Arg-1 expression.
The results obtained in the present study suggest that a signaling pathway mediated by FcRg or the FcRg-Syk axis is commonly required for innate basophil IL-4 responses under conditions mimicking encounters with allergen sources.
IL-4Delta2 did not compete with IL-4 for IL-4Ralpha binding and did not interfere with the downstream STAT-6 phosphorylation in T cells.
this study shows that IL4 and IL21 cooperate to induce the high Bcl6 protein level required for germinal center formation
The complex role of IL-4 in autoimmunity and cholangitis.
The results demonstrate that IL-4 can restore insulin sensitivity in adipocytes via mechanisms not associated with induced adipogenesis or de novo formation of lipid depots.
Interleukin 4 (IL-4) signaling prevents Chlamydia trachomatis Infection from Inducing upper genital tract (UGT) pathology.
In the lung, surfactant protein A (SP-A) enhanced interleukin-4 (IL-4)-dependent macrophage proliferation and activation, accelerating parasite clearance and reducing pulmonary injury after infection with a lung-migrating helminth. In the peritoneal cavity and liver, C1q enhancement of type 2 macrophage activation was required for liver repair after bacterial infection.
Data, including data from studies using transgenic mice, suggest that over-expression of IL4 (interleukin 4) in thyroid tissue/cells up-regulates expression of Duox1 (dual oxidase 1), Duoxa1 (dual oxidase maturation factor 1), and Slc26a4 (pendrin) in thyroid tissue/cells; expression of Slc5a5 (sodium-iodide symporter) is down-regulated.
NK cells activated by IL-4 in cooperation with IL-15 exhibit distinctive characteristics with enhanced immunologic cytotoxicity.
we defined a molecular mechanism for IL-4 downregulation of involucrin in keratinocytes, which may play an important role in the pathogenesis of AD.
In this study, the effect of continuous IL-4 delivery or bioactive implant coating that constitutively releases a protein inhibitor of CCL2 signaling (7ND) on particle induced osteolysis were studied in the murine continuous femoral intramedullary particle infusion model
T follicular helper (Tfh) cells arise in tumor-draining lymph nodes where they produce an abundance of IL4. Deletion of IL4-expressing Tfh cells improves antitumor immunity, delays tumor growth, and reduces the generation of immunosuppressive myeloid cells in the lymph nodes.
Findings suggest that interleukin 4 (IL-4) affects anti-tumor immunity and constitutes an attractive therapeutic target to reduce immune suppression in the tumor microenvironment.
this study shows that environmental IL-4 plays a role in conditioning early thymic progenitors lineage choice, which would impact T cell development
IL-4 and IL-13 are required to effectively polarize macrophages/dendritic cells to an M2a phenotype and to promote recovery from acute kidney injury.
These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma occurring after parturition and an increase in IL-4 production before calving.
IL-4 may play a role in coordinating the adrenal response to inflammatory stress.
T helper (Th) type 2 cell cytokine IL-4 modulates airway contraction by secreting matrix metalloproteinase-1 from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.
IL-4- and IL-10-producing invariant NKT cells inhibit the Th1 cell response, but not the Th17 cell response
IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.
There was no significant difference of IL-4 production between fresh and frozen peripheral blood mononuclear cells.
The endothelium and subendothelium of porcine iliac arteries that are transduced with recombinant pig IL-4 are effectively protected from complement-dependent immediate injury after perfusion with human blood.
unlike in humans and mice, porcine IL-4 blocks antibody and IL-6 secretion and suppresses antigen-stimulated proliferation of B cells
Data indicate that animals exposed to high lead concentration, the levels of IFNgamma and IFNgamma/IL-4 ratio were significantly lower than those exposed to its low concentration.
IL-4 and STAT6 are related to the pathogenesis of allergic rhinitis and may be the main factors for eosinophil infiltration in allergic rhinitis.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 biased, interferon-gamma production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.
This study showed that pronounced lung eosinophilia in horses can be transient, abate without specific treatment, and in this instance, lack correlation to upregulation of expression of either IL-4 or IL-5.
Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine genes IL4.
Mycobacterial infections of macaques induce mRNA encoding a variant IL-4 that functions as a growth factor to promote expansion of 4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T effector cells.
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
, B cell growth factor 1
, B_cell stimulatory factor 1
, lymphocyte stimulatory factor 1
, B-cell IgG differentiation factor
, B-cell growth factor 1
, B-cell stimulatory factor 1
, IGG1 induction factor
, B-cell IGG differentiation factor
, Lymphocyte stimulatory factor 1