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Melatonin, added together with MPTP (zeige PTPN2 Proteine) or added once MPTP (zeige PTPN2 Proteine) was removed, prevented and recovered, respectively, the parkinsonian phenotype once it was established, restoring gene expression and normal function of the parkin (zeige PARK2 Proteine)/PINK1 (zeige PINK1 Proteine)/DJ-1/MUL1 loop and also the normal motor activity of the embryos.
These studies show that zDJ-1 is very similar to human DJ-1 and is evolutionarily conserved and expressed in dopaminergic neurons.
Low DJ-1 expression impairs synaptic vesicle endocytosis and reavailability at nerve terminals.
DJ-1 deficiency causes defects in astrocyte-mediated repair of brain damage.
In cultured neurons and forebrain samples from Dj1(-/-) animals, there was chloride damage and a profound structural remodeling of the mitochondrial respiratory chain.
DJ-1 has a role in glutamate (zeige GRIN1 Proteine) uptake into astrocytes by regulating flotillin-1 (zeige FLOT1 Proteine) and caveolin-1 (zeige CAV1 Proteine) expression
Network analysis reveals DJ-1/LDLR (zeige LDLR Proteine) as common host proteins modulating pathogenesis of neurotropic viruses.
Induction of DJ-1 may serve as a novel regulator for hepatocellular carcinoma cell proliferation and HCC (zeige FAM126A Proteine) development possibly through enhanced MAPK (zeige MAPK1 Proteine) signaling and inflammation.
chaperone-mediated autophagy protects mitochondrial function by degrading nonfunctional PARK7 and maintaining its homeostasis, and dysregulation of this pathway may contribute to the neuronal stress and death in Parkinson disease pathogenesis
Knockdown of DJ-1 attenuates Nurr1 (zeige NR4A2 Proteine) activity.
These results demonstrate that DJ-1 KO mice display progressive signs of retinal/RPE (zeige RPE Proteine) degeneration in association with higher levels of oxidative stress markers. Collectively this analysis indicates that DJ-1 plays an important role in protecting photoreceptors and RPE (zeige RPE Proteine) from oxidative damage during aging
DJ-1 activates autophagy to alleviate cardiac hypertrophy.
DJ-1 promoter polymorphism is associated with male infertility.
The PD-associated L166P mutant, but not wild-type DJ-1, directly binds to and is cleaved by the mitochondrial serine protease Omi (zeige HTRA2 Proteine) at both serine residues 3 and 121.
DJ-1 plays a major role in various signaling pathways. Related to its anti-oxidant properties, it mediates cell survival and proliferation by activating the extracellular signal-regulated kinase (ERK1/2) pathway and attenuates cell death signaling by inhibiting apoptosis signal-regulating kinase 1 (ASK1 (zeige MAP3K5 Proteine)) activation. [review]
the present study highlighted the involvement of DJ1 in HGrelated EC injury and identified that DJ1 exerts a cellular protective effect in HUVECs exposed to HG induced oxidative stress via activation of the PI3K (zeige PIK3CA Proteine)/AkteNOS signaling pathway.
These findings suggest that oxidation-induced ubiquitination and degradation can be a quality control mechanism of oxidized redox-sensitive proteins including Prxs and DJ-1.
study implies that DJ-1 may protect endothelial progenitor cells against Ang II (zeige AGT Proteine)-induced dysfunction by activating the PPARgamma (zeige PPARG Proteine)/HO-1 (zeige HMOX1 Proteine).
Studied serum levels of Parkinson's disease-associated protein 7 (DJ-1) and human epididymis protein 4 (HE4 (zeige WFDC2 Proteine)) in endometrial cancer (EC) patients and healthy controls. The median serum concentrations of DJ-1 and HE4 (zeige WFDC2 Proteine) were found to be significantly higher in EC patients compared to controls.
Study shows the generation of oxDJ-1 in erythrocytes in early stage, unmedicated parkinson's disease (PD) patients and in non-human primates with PD symptoms. In addition, oxDJ-1 interacts with 20S proteasome (zeige PSMA5 Proteine) in the erythrocytes of PD patients. The current findings suggest that oxidative stress is systemically present in PD patients and suggest that an early pathophysiological mechanism operates in PD.
Not only is protein deglycase DJ-1 (DJ-1) linked to familial Parkinson's disease (PD), but it is also associated with the pathogenic mechanisms of sporadic PD and other neurodegenerative disorders where oxidative stress is implicated [Review].
Studies indicate that protein deglycase DJ-1 (DJ-1) plays a critical role in cancer [Review]
The PARK7 gene was demonstrated to be located on porcine chromosome 6
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.
, parkinson disease protein 7 homolog
, protein DJ-1
, Parkinson disease 7
, RNA-binding protein regulatory subunit
, Parkinson disease (autosomal recessive, early onset) 7
, oncogene DJ1
, contraception-associated protein 1
, fertility protein SP22