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Data suggests that NRIP1 is overexpressed both in skin and PBMCs of psoriasis patients and may be involved in the abnormal proliferation and apoptosis of keratinocytes.
In skeletal muscle, imposed rest increased NRIP1 expression by 80%, and strength training increased expression by 25% compared to baseline. Following rest, NRIP1 expression became sensitive to insulin stimulation. After re-training, NRIP1 expression decreased. Interactome analysis showed significant proximity of NRIP1 interacting partners to the obesity network/module.
Taken together, these results provide new insights into the mechanism of action of LCoR and RIP140 and highlight their strong interplay for the control of gene expression and cell proliferation in breast cancer cells.
Study found low expression level of RIP140 in tumor-associated macrophages (TAM) of hepatocellular carcinoma (HCC) tissues and demonstrated that RIP140 expression in plays a role in the growth of hepatoma cells.
results indicated that there was a significant association between migraine and gene-gene interaction among the CYP19A1, FSHR, ESR1 and NRIP1.
Data indicate that nuclear receptor interacting protein 1 (NRIP1) is elevated in tumors compared to cancer adjacent normal tissue.
NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/beta-catenin pathway.
NRIP1 contributes to the mitochondrial dysfunction observed in DS. Furthermore, they suggest that the NRIP1-PGC-1alpha axe might represent a potential therapeutic target for restoring altered mitochondrial function in DS.
RIP140 gene has been shown to be involved in the regulation of energy expenditure, in mammary gland development and intestinal homeostasis as well as in behavior and cognition
Downregulation of RIP140 promoted the tumorigenicity of HCC cells in vitro.
Data suggest that vitamin D receptor target genes (NRIP1; DUSP10, dual specificity phosphatase 10; THBD, thrombomodulin; TRAK1, trafficking protein kinesin binding 1) can be used as markers for individual's response to vitamin D3 supplements.
RIP140 negatively regulated the macrophage expression of ATP-binding cassette transporters A1 and G1.
The associations of rs2616984 in CSMD1 gene, putative associations of rs3131296 in NOTCH4 gene, and associations of rs2229741 of NRIP1 gene with Alzheimer's disease have been found in a Russian population.
data suggest that RIP140 plays an important role in ERalpha-mediated transcriptional regulation in breast cancer and response to tamoxifen treatment
In breast cancer cells, GSTP1 inhibits the expression of RIP140, a negative regulator of estrogen receptor alpha transcription, at both mRNA and protein levels.
RIP140 stimulated APC transcription and inhibited beta-catenin activation and target gene expression.
these data demonstrate the inhibitory effects of ERbeta on estrogen signaling in ovarian cancer cells and the key role that RIP140 plays in this phenomenon.
Estrogen receptors alpha and beta and their key coregulators, SRC3 and RIP140, generate overlapping as well as unique chromatin-binding and transcription-regulating modules.
genetic association studies in population of women in Spain: Data suggest an association between an SNP in NRIP1 (rs2229741) and age at menopause; thus, duration of fertility in women may have genetic determinants involved in estrogen metabolism.
Increased RIP140 level may be closely associated with inflammation and disorder of lipid and glucose metabolism in diabetic patients.
Up-regulation of RIP140 promotes glucolipotoxicity-induced damage in pancreatic beta cells.
RIP140 is a co-repressor of HSF1, and it regulates neuronal stress response.
It is able to modulate the transcription of certain genes involved in AD pathology, such as b-APP cleaving enzyme (BACE1) and GSK3. Consequently, we found that RIP140 overexpression reduced the generation of Ab in a neuroblastoma cell line by decreasing the transcription of b-APP cleaving enzyme via a PPARge dependent mechanism.
These data indicate that dominant NRIP1 mutations can cause kidney and urinary tract by interference with retinoic acid transcriptional signaling, shedding light on the well documented association between abnormal vitamin A levels and renal malformations in humans, and suggest a possible gene-environment pathomechanism in this disease
RIP140 has a unique role in the acute effect of beta-3 adrenergic receptor activation.
depletion of receptor-interacting protein 140 could significantly alleviate the inhibitory effects of estrogen on osteoclasts formation and bone resorption activity.
RIP140 protects LSD1's catalytic domain and antagonizes its Jade-2-mediated ubiquitination and degradation.
Nuclear receptor interacting protein 140 (RIP140) is an identified nuclear receptor corepressor that has been shown to suppress mitochondrial biogenesis in skeletal muscle.
Data show that 7,12-dimethylbenzanthracene (DMBA)-induced carcinogenesis is suppressed in nuclear receptor interacting protein 1 (Nrip1) knockout mice.
RIP140 plays an important role in maintaining brain cholesterol homeostasis through, partially, regulating cholesterol metabolism in, and mobilization from, astrocyte.
RIP140 translocation to the cytoplasm is an early response to ER stress and provides protection against neuronal death.
Study revealed an emotional regulatory function of macrophage-derived RIP140 in the VMH, and secondary dysregulation of NPY within hypothalamic astrocyte population, which might be associated with the observed behavioral phenotype of MPhiRIPKD mice.
RIP140 knockdown in macrophages led to significant white adipose tissue browning, improved systemic insulin sensitivity, particularly under high fat diet feeding, and an altered adipose tissue macrophage profile.
RIP140 blocks the BRITE program in white adipose tissue.
RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals.
RIP140 effectively inhibits the proliferation and facilitates the apoptosis of microglioma cells.
IGF1 may coregulate female sexual maturation and longevity; wild-derived strains carry specific alleles that delay sexual maturation; and Nrip1 is involved in regulating sexual maturation and may affect longevity by regulating IGF1 level.
Findings reinforce the participation of RIP140 in the maintenance of energy homeostasis by acting as an inhibitor of energy production.
Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor.
nuclear receptor interacting protein 1
, nuclear receptor-interacting protein 1-like
, nuclear factor RIP140
, nuclear receptor-interacting protein 1
, receptor interacting protein 140
, receptor-interacting protein 140