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anti-Human SMG1 Antikörper:
anti-Mouse (Murine) SMG1 Antikörper:
anti-Cow (Bovine) SMG1 Antikörper:
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Human Polyclonal SMG1 Primary Antibody für WB - ABIN250701
Kaizuka, Hara, Oshiro, Kikkawa, Yonezawa, Takehana, Iemura, Natsume, Mizushima: Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. in The Journal of biological chemistry 2010
Show all 3 Pubmed References
Human Monoclonal SMG1 Primary Antibody für IHC (p), ELISA - ABIN524936
Stalder, Mühlemann: Processing bodies are not required for mammalian nonsense-mediated mRNA decay. in RNA (New York, N.Y.) 2009
Show all 2 Pubmed References
Human Polyclonal SMG1 Primary Antibody für IP, PLA - ABIN262228
Usuki, Yamashita, Fujimura: Post-transcriptional defects of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure. in The Journal of biological chemistry 2011
Knock down of the expression of SMG-1 inhibited tumor cell proliferation and induced the chemosensitivity of pancreatic cancer cells in vitro.
SMG1 was hypermethylated in 66% of AML (zeige RUNX1 Antikörper) samples compared with none in controls. mTOR (zeige FRAP1 Antikörper) expression level was negatively correlated to SMG1 expression in AML (zeige RUNX1 Antikörper) patients which indicated that SMG1 and mTOR (zeige FRAP1 Antikörper) maybe act antagonistically to regulate AML (zeige RUNX1 Antikörper) cell growth.
A genome-wide RNA interference screen Hepatocellular carcinoma cell lines revealed the role of suppressor of SMG-1 as determinant of sorafenib resistance.
SMG1 regulates NMD by recruiting UPF1 (zeige UPF1 Antikörper) and UPF2 (zeige UPF2 Antikörper) to distinct nearby positions, and can form a complex with UPF2 (zeige UPF2 Antikörper) in vivo in an UPF1 (zeige UPF1 Antikörper)-independent manner.
We conclude that SMG-1 is downregulated in HCC (zeige FAM126A Antikörper) and may represent a promising biomarker for predicting the prognosis of HCC (zeige FAM126A Antikörper), including the prognosis of early-stage patients.
Novel role for SMG-1 is identified in regulating Cdc25A (zeige CDC25A Antikörper) and suppressing oncogenic CDK2 (zeige CDK2 Antikörper) driven proliferation, confirming SMG-1 as a tumor suppressor.
This study demonstrated the quantitative regulation of Upf1 (zeige UPF1 Antikörper) and Upf2 (zeige UPF2 Antikörper) proteins by ubiquitin-proteasome system and SMG1.
SMG1 protein levels were significantly reduced in brain.
Downregulation of SMG1 causes the reduction in the level of Upf1 (zeige UPF1 Antikörper) phosphorylation and delays adipogenesis, suggesting the functional involvement of SMG1 in adipogenesis via SMD.
Data indicate that down-regulation of SMG1 expression is mediated by miRNA-125 binding to a microRNA response element in the 3' untranslated region of SMG1 mRNA, which leads to degradation of the SMG1 mRNA.
smg-1 mutations confer strong hyper-sensitivity to IR. SMG-1 does not appear to act in any of the three major pathways known to mend DNA DSBs.
The CK2 (zeige CSNK2A1 Antikörper) phospho-dependent interaction between TEL2 (zeige TELO2 Antikörper) and the R2TP complex affects phosphatidylinositol 3-kinase-related kinase functions and is essential for mTOR (zeige FRAP1 Antikörper) and SMG1 stability in vivo.
Results demonstrate a critical role for Smg1 in early mouse development and link the loss of this NMD factor to major and widespread changes in the mammalian transcriptome.
smg-1 encodes a protein kinase (zeige CDK7 Antikörper) of the phosphatidylinositol kinase superfamily of protein kinases; SMG-1 kinase activity is required in vivo for nonsense-mediated mRNA decay and in vitro for SMG-2 (zeige UPF1 Antikörper) phosphorylation
A novel role is reported for smg-1 in lifespan and oxidative stress resistance in Caenorhabditis elegans.
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined.
PI-3-kinase-related kinase SMG-1
, lambda-interacting protein
, lambda/iota protein kinase C-interacting protein
, serine/threonine-protein kinase SMG1
, smg-1 homolog, phosphatidylinositol 3-kinase-related kinase
, phosphatidylinositol 3-kinase-related protein kinase
, SMG1 homolog, phosphatidylinositol 3-kinase-related kinase