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Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305109
Chiu, Moulds, Coffman, Rennick, Lee: Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. in Proceedings of the National Academy of Sciences of the United States of America 1988
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Rat (Rattus) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305110
Van Snick, Cayphas, Szikora, Renauld, Van Roost, Boon, Simpson: cDNA cloning of murine interleukin-HP1: homology with human interleukin 6. in European journal of immunology 1988
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Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305111
Kitamura, Takaku, Miyajima: IL-1 up-regulates the expression of cytokine receptors on a factor-dependent human hemopoietic cell line, TF-1. in International immunology 1991
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Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN620832
Leyh, Seitz, Dürselen, Schaumburger, Ignatius, Grifka, Grässel: Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes. in Arthritis research & therapy 2015
Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN804234
Han, Kitamoto, Wang, Boisvert: Interleukin-10 overexpression in macrophages suppresses atherosclerosis in hyperlipidemic mice. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN935537
Spatz, Eibl, Hink, Wolf, Fischer, Mayr, Schernthaner, Eibl: Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. in Cellular immunology 2003
Rat (Rattus) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1525747
Andrianjafiniony, Dupré-Aucouturier, Letexier, Couchoux, Desplanches: Oxidative stress, apoptosis, and proteolysis in skeletal muscle repair after unloading. in American journal of physiology. Cell physiology 2010
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1878195
Fan, Ren, Zhu, Zhang, Zhu: A new signal amplification strategy of photoelectrochemical immunoassay for highly sensitive interleukin-6 detection based on TiO2/CdS/CdSe dual co-sensitized structure. in Biosensors & bioelectronics 2014
the single nucleotide polymorphism rs1800797 of IL6 may be a susceptibility gene for major depressive disorder
the association between TLR3 (zeige TLR3 Proteine), TLR4 (zeige TLR4 Proteine) variants and nine IL-6 polymorphisms, and response to anti-viral treatment during hepatitis C infection.
this study shows age-related increases in serum and PBMC IL-6 in healthy nonobese subjects
hese findings suggest that variations in IL6, CXCL8 (zeige IL8 Proteine), and TNF (zeige TNF Proteine) are associated with the development and maintenance of mild persistent breast pain.
theses results suggest that IL-6 genotypes of recipient are the most associated with the risk of complications after haematopoietic stem cell transplantation
serum concentrations of IL-6 and IL-10 (zeige IL10 Proteine) but not TNFa (zeige TNF Proteine) in patients with internal carotid artery stenosis allow to predict the progression of the degree of stenosis and the unfavorable change of atherosclerotic plaque morphology
Approximately half of the knee osteoarthritis patients were found to be in the depressive state, and their serum IL-6 levels to be associated with the depressive state, irrespective of osteoarthritis severity.
increased levels of IL-6 are associated with factors of worse prognosis in ovarian cancer
IL-6 upregulation in the adventitia was characterized by activated immune reactions in IgG4-abdominal aortic aneurysm patients. IL-6 synthesis, through contributions of mesenchymal cells and macrophages in the adventitia, is strongly involved in IgG4-AA pathogenesis or progression, or both.
IL-11 (zeige IL11 Proteine), an IL-6 Family Cytokine, promotes Non-Small Cell Lung Cancer cell proliferation in vitro and tumorigenesis in vivo.
IL 6 and TGF beta (zeige TGFB1 Proteine) perform essential role in cerebral malaria pathogenesis by modulating the level of glial cell induced neuroinflammation.
EMMPRIN inhibited bFGF (zeige FGF2 Proteine)-induced IL-6 secretion by reducing the p65 (zeige NFkBP65 Proteine) subunit phosphorylation, it might be concluded that bFGF (zeige FGF2 Proteine) and EMMPRIN crosstalk in their respective signaling pathways.
pathologic levels of IL-6 in the periphery may play a role in the development of seizures when viral replication within the brain is limited following infection with a variant of Theiler's murine encephalomyelitis virus that does not replicate within the parenchyma of the brain.
IL-33 (zeige IL33 Proteine) may induce Th17 cell responses via IL-1beta (zeige IL1B Proteine) and IL-6 derived from IL-33 (zeige IL33 Proteine)-matured dendritic cells.
TIARP (zeige STEAP4 Proteine) independently down-regulated CXCL2 (zeige CXCL2 Proteine) and IL-6 production by fibroblast-like synoviocytes, and the expression of chemokine (zeige CCL1 Proteine) receptors (CXCR1 (zeige CXCR1 Proteine) and CXCR2 (zeige CXCR2 Proteine)) in neutrophils, with resultant reduction of neutrophil migration into arthritic joints.
ESP of fifth-stage larval Angiostrongylus cantonensis stimulates astrocyte activation and IL-1beta (zeige IL1B Proteine) and IL-6 production through NF-kappaB (zeige NFKB1 Proteine) and the Shh (zeige SHH Proteine) signaling pathway.
these findings revealed a novel and unexpected role of IL-6 in ameliorating acute liver injury via regulating inflammatory responses in hepatic macrophages
increased circulating levels of IL-6 perturb the redox signaling cascade, even prior to the necrotic stage, leading to severe features and progressive nature of muscular dystrophy.
LPS (zeige TLR4 Proteine) increased mRNA and protein expressions of IL-6 and RANKL (zeige TNFSF11 Proteine) on day 14
The in vitro findings suggest that GTS-21-induced IL-6 release from muscle is mediated via alpha7AChRs upstream of Stat-3 (zeige STAT3 Proteine) and -5 pathways and is associated with myonuclear accretion, possibly via MyoD (zeige MYOD1 Proteine) and Pax7 (zeige PAX7 Proteine) expression.
Mild heat shock increased the production of inflammatory cytokines, IL-1beta (zeige IL1B Proteine) and IL-6 in rabbit cornea cells.
These data suggest that IL-6 may play a key role in equine metabolic syndrome (EMS), and that pro-inflammatory cytokines levels in serum may serve as an additional tool for diagnosing EMS.
IL-6 stimulation decreased chondrocyte expression of the canonical Wnt (zeige WNT2 Proteine) signaling pathway transactivator beta-catenin (zeige CTNNB1 Proteine), induced expression of inhibitors of the Wnt (zeige WNT2 Proteine) pathway, and increased expression of GDF-5 (zeige GDF5 Proteine).
study shows that IL-6 is rapidly induced in BAL-cells of airway-compromised horses in response to adenosine exposure, probably through A2BAR (zeige ADORA2B Proteine) activation and that this effect can be modulated by A2AAR (zeige ADORA2A Proteine)
Our data show the presence of a polymorphism downstream of the equine IL-6 gene that is associated with the basal Cu:Zn ratio in horses independent of breed.
Expression levels of IL-6 are significantly increased in peripheral blood mononuclear cells from trained horses compared to sedentary animals.
Failure of passive transfer may directly influence the serum IL-6 concentration in septic foals. Neither serum IL-6 nor IL-10 (zeige IL10 Proteine) alone, were useful diagnostic indices of sepsis in equine neonates.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 (zeige IL10 Proteine) and TNF-alpha (zeige TNF Proteine), in horses with recurrent airway obstruction during exacerbation and in remission is reported.
The role of IL-6 and its signaling pathway in enhancing colonic proliferation.Il-6 is a key regulator of chronic intestinal inflammation.
we showed that IL-6 did not directly promote the proliferation of theca interna cells.
Induction of ischemic osteonecrosis results in IL-6 production in the articular cartilage through an HIF-1 (zeige HIF1A Proteine)-dependent pathway. IL-6 produced by hypoxic articular chondrocytes stimulates inflammatory cytokine responses in synovial cells.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (zeige TGFB1 Proteine), IL-10 (zeige IL10 Proteine), and IL-6 in ovarian follicles are reported.
Data suggest IL6 prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst viability via IL6/STAT3 (zeige STAT3 Proteine) (signal transducer/activator of transcription (zeige STAT1 Proteine) 3) signaling pathway (including up-regulation of STAT3 (zeige STAT3 Proteine) expression/phosphorylation).
LIF (zeige LIF Proteine) and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
INFgamma and IL-6 modulate PPARs gene expression in the porcine endometrium during the estrous cycle and pregnancy.
IL-6 was low or undetectable in Boar seminal plasma.
interleukin-6, endothelin ET-1 (zeige EDN1 Proteine), and apoptotic Bak (zeige BAK1 Proteine) and Bcl-XL (zeige BCL2L1 Proteine) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Data show that all five molecules, BNP, ICAM-1 (zeige ICAM1 Proteine), TNF-alpha (zeige TNF Proteine), VCAM-1 (zeige VCAM1 Proteine) and IL-6, quickly and reliably signaled adverse interactions.
STA3 (zeige ARHGEF3 Proteine) facilitates TLR4 (zeige TLR4 Proteine)-dependent IL-6 and IL-8 (zeige IL8 Proteine) production via IL-6 receptor-positive feedback in endometrial cells.
when a confluent endometrial epithelial cell barrier is faced with infection and damage, chemokines attract immune cells to the uterine lumen, but IL6 is solely secreted apically to ensure immune cells are only exposed to IL6 once they reach the lumen.
The results revealed that the peak expression of IL6 and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (zeige IL8 Proteine) and PTGS2 (zeige PTGS2 Proteine), and decreased the expression of SOD2 (zeige SOD2 Proteine), GPX3 (zeige GPX3 Proteine), DAB2 (zeige DAB2 Proteine), and NR3C1 (zeige NR3C1 Proteine). TNF (zeige TNF Proteine) and IL6 levels were also decreased while those of NAMPT (zeige NAMPT Proteine) were unaffected.
Testicular IL-1 alpha (zeige IL1A Proteine) and IL-1 beta (zeige IL1B Proteine) concentrations were highest in the early post-natal period; however, IL-1 (zeige IL1A Proteine) bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.
The results showed that the expression of TNF-alpha (zeige TNF Proteine), iNOS (zeige NOS2 Proteine), and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (zeige IL12A Proteine) was unaffected.[IL-6, IL-12 (zeige IL12A Proteine)]
results show for the first time that interleukin-6 (IL6), in the presence of its soluble receptor (zeige IFNAR1 Proteine) (sIL-6R), induces activation of JAK1 (zeige JAK1 Proteine), JAK2 (zeige JAK2 Proteine), and STAT1 (zeige STAT1 Proteine)/STAT3 (zeige STAT3 Proteine) proteins in bovine articular chondrocytes.
Mechanical injury potentiates the catabolic effects of TNFalpha (zeige TNF Proteine) and IL-6/sIL-6R in causing proteoglycan (zeige Vcan Proteine) degradation in human and bovine cartilage.
Plasma nitric oxide acts as a regulator of cytokine function exhibiting negative feedback to maintain steady plasma IL-6 concentration in protein- or energy-restricted goats during late gestation.
The results reveal that, in trout, IL-6 is a differentiation factor for B cells, stimulating IgM responses in the absence of follicular structures, and suggest that it was after follicular structures appeared that this cytokine evolved to modulate T-dependent responses within the germinal centers.
IL6 mRNA abundance was significantly increased in spleen, liver, and gill of rainbow trout after experimental infection with Aeromonas salmonicida.
in this paper we present for the first time in fish the functional characterisation of IL-6, using rainbow trout
found that peptidoglycans derived from Gram-negative bacteria (Escherichia coli 0111:B4 and K12 (zeige KRT12 Proteine)), are potent inducers of IL-1beta (zeige IL1B Proteine) and IL-6 gene expression and were equal to, or more potent than, crude LPS (zeige IRF6 Proteine).
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
B-cell differentiation factor
, B-cell stimulatory factor 2
, CTL differentiation factor
, hybridoma growth factor
, interferon beta-2
, interleukin BSF-2
, B-cell hybridoma growth factor
, interleukin HP-1
, Interleukin 6 (interferon, beta 2)
, interleukin-6 protein
, interleukin 6 (interferon, beta 2)