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Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305109
Chiu, Moulds, Coffman, Rennick, Lee: Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. in Proceedings of the National Academy of Sciences of the United States of America 1988
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Rat (Rattus) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305110
Van Snick, Cayphas, Szikora, Renauld, Van Roost, Boon, Simpson: cDNA cloning of murine interleukin-HP1: homology with human interleukin 6. in European journal of immunology 1988
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Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305111
Kitamura, Takaku, Miyajima: IL-1 up-regulates the expression of cytokine receptors on a factor-dependent human hemopoietic cell line, TF-1. in International immunology 1991
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Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN803874
Tan, Li, Rajendran, Kumar, Hui, Sethi et al.: Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis ... in The Journal of pharmacology and experimental therapeutics 2010
Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN804234
Han, Kitamoto, Wang, Boisvert: Interleukin-10 overexpression in macrophages suppresses atherosclerosis in hyperlipidemic mice. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1112348
Xin, Mizukami, Urabe, Toda, Shinoda, Yoshida, Oomura, Kojima, Ichino, Klinman, Ozawa, Okuda: Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells. in Journal of virology 2006
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1589641
Poli, Asperti, Ruzzenenti, Mandelli, Campostrini, Martini, Di Somma, Maccarinelli, Girelli, Naggi, Arosio: Oversulfated heparins with low anticoagulant activity are strong and fast inhibitors of hepcidin expression in vitro and in vivo. in Biochemical pharmacology 2014
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN620832
Leyh, Seitz, Dürselen, Schaumburger, Ignatius, Grifka, Grässel: Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes. in Arthritis research & therapy 2015
Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1878195
Fan, Ren, Zhu, Zhang, Zhu: A new signal amplification strategy of photoelectrochemical immunoassay for highly sensitive interleukin-6 detection based on TiO2/CdS/CdSe dual co-sensitized structure. in Biosensors & bioelectronics 2014
Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN935535
Spatz, Eibl, Hink, Wolf, Fischer, Mayr, Schernthaner, Eibl: Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. in Cellular immunology 2003
These results show that the systemic IL-6 effector pathway mediates bone deterioration induced by repetitive inhalant ODE exposures through an effect on osteoclasts, but a positive role for IL-6 in the airway was not demonstrated. IL-6 might be an important link in explaining the lung-bone inflammatory axis.
skeletal muscle IL-6 contributes to reestablishing metabolic homeostasis during recovery from exercise by regulating WAT and skeletal muscle metabolism
pattern of STAT (zeige STAT1 Proteine) indicates that possibly TGF-beta (zeige TGFB1 Proteine) and IL-6 play a crucial role in differentiation of DCs subsets and Treg/Th17 imbalance during experimental cerebral malaria (ECM (zeige MMRN1 Proteine)).
IL-6 promotes CD4 (zeige CD4 Proteine)(+) T-cell activation and B-cell responses during blood-stage Plasmodium infection, which encourages parasite-specific antibody production.
The current study demonstrated that honey can stimulate or suppress the mRNA expression of some pro-inflammatory cytokines in mice brains. Furthermore, honey suppresses the TNF-alpha (zeige TNF Proteine) mRNA expression in the presence of T. gondii infection but it stimulates the IL-1beta (zeige IL1B Proteine) and IL-6 mRNA expression. Treatment of the mice with honey reduces parasite multiplication in the brain.
Both IL-6 protein production and transcript levels were downregulated by RA in respiratory tract epithelial cells (LETs) , but upregulated in macrophages (MACs). RA also increased transcript levels of MCP-1 (zeige CPT1B Proteine), GMCSF (zeige CSF2 Proteine), and IL-10 (zeige IL10 Proteine) in MACs, but not in LETs. Conversely, when LETs, but not MACs, were exposed to RA
A2BARs activation increased IL-6 secretion.
In the context of the elastase model of abdominal aortic aneurysm disease, IL-6 appears a multi-faceted factor, protective upon acute injury, but negatively involved in the perpetuation of the disease process
Results demonstrate that increased tumor-associated macrophages-derived IL-6 had an amplifying effect on the inflammation response, thereby promoting the occurrence and development of hepatocellular carcinoma (HCC (zeige FAM126A Proteine)).
activation of beta2-AR accelerated hepatocyte proliferation and improved recellularized liver function by mediating the IL-6/Stat 3 (zeige STAT3 Proteine) signalling pathway, indicating that nervous system regulation may be an essential component contributing to the complexity of recellularized liver in tissue engineering
Results indicate that the IL-6/STAT3 (zeige STAT3 Proteine)/NF-kappaB (zeige NFKB1 Proteine) positive feedback loop includes AUF1 (zeige HNRNPD Proteine) and is responsible for the sustained active status of cancer-associated fibroblasts.
The sgp130, IL-6, and sIL (zeige PMEL Proteine)-6R concentrations were statistically significantly elevated in patients with diabetic retinopathy (DR), suggesting a probable contributing role of the IL-6 trans-signaling pathway to the pathophysiology of DR.
WNT5A (zeige WNT5A Proteine) and IL-6 are connected through a positive feedback loop in melanoma cells
Work provide new evidences that upregulated Notch (zeige NOTCH1 Proteine) signaling supports multiple myeloma (MM) cell growth and contributes to disease progression by promoting activation of an IL-6 autocrine loop in MM and favoring IL-6 paracrine release by the surrounding bone marrow stromal cells.
The present study suggests that serum IL-6 levels of patients with AD might be higher than those of subjects with MCI (zeige MCIN Proteine) and healthy controls.
Most symptoms of the plasma cell variant of Castleman disease are linked to the hyperfunction of IL-6, constitutively produced in the affected lymph nodes (1989), suggesting IL-6 is key in the pathogenesis of multicentric Castleman disease (MCD).
Patients with high level of IL-6 had increased burden of coronary atherosclerosis and higher MACE risk compared to participants of low level of IL-6.
Schoolchildren who were overweight/obese had higher levels of CRP (zeige CRP Proteine) and IL-6, whereas individuals with WC and BF% alterations had higher levels of CRP (zeige CRP Proteine).
recommend the use of IL-6 as a diagnostic aid to confirm infection rather than exclude infection in patients with systemic inflammatory response syndrome.
the optimal discrimination cut-off for each cytokine: sVEGFR-1 (2124.5pg/mL), IL-6 (40.2pg/mL), VEGF-A (zeige VEGFA Proteine) (1060.1pg/mL), Angiopoeintin-2 (913.7pg/mL), uPA (zeige PRAP1 Proteine) (248.1pg/mL), sHER-2/neu (zeige ERBB2 Proteine) (5010pg/mL) and PLGF (zeige PGF Proteine) (93.4pg/mL). For the very first time, a novel cytokine profile associated with cancer metastasis to the paratracheal lymph nodes were reported.
STA3 (zeige ARHGEF3 Proteine) facilitates TLR4 (zeige TLR4 Proteine)-dependent IL-6 and IL-8 (zeige IL8 Proteine) production via IL-6 receptor-positive feedback in endometrial cells.
when a confluent endometrial epithelial cell barrier is faced with infection and damage, chemokines attract immune cells to the uterine lumen, but IL6 is solely secreted apically to ensure immune cells are only exposed to IL6 once they reach the lumen.
The results revealed that the peak expression of IL6 and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (zeige IL8 Proteine) and PTGS2 (zeige PTGS2 Proteine), and decreased the expression of SOD2 (zeige SOD2 Proteine), GPX3 (zeige GPX3 Proteine), DAB2 (zeige DAB2 Proteine), and NR3C1 (zeige NR3C1 Proteine). TNF (zeige TNF Proteine) and IL6 levels were also decreased while those of NAMPT (zeige NAMPT Proteine) were unaffected.
Testicular IL-1 alpha (zeige IL1A Proteine) and IL-1 beta (zeige IL1B Proteine) concentrations were highest in the early post-natal period; however, IL-1 (zeige IL1A Proteine) bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.
The results showed that the expression of TNF-alpha (zeige TNF Proteine), iNOS (zeige NOS2 Proteine), and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (zeige IL12A Proteine) was unaffected.[IL-6, IL-12 (zeige IL12A Proteine)]
results show for the first time that interleukin-6 (IL6), in the presence of its soluble receptor (zeige IFNAR1 Proteine) (sIL-6R), induces activation of JAK1 (zeige JAK1 Proteine), JAK2 (zeige JAK2 Proteine), and STAT1 (zeige STAT1 Proteine)/STAT3 (zeige STAT3 Proteine) proteins in bovine articular chondrocytes.
Mechanical injury potentiates the catabolic effects of TNFalpha (zeige TNF Proteine) and IL-6/sIL-6R in causing proteoglycan (zeige Vcan Proteine) degradation in human and bovine cartilage.
Mild heat shock increased the production of inflammatory cytokines, IL-1beta (zeige IL1B Proteine) and IL-6 in rabbit cornea cells.
we showed that IL-6 did not directly promote the proliferation of theca interna cells.
Induction of ischemic osteonecrosis results in IL-6 production in the articular cartilage through an HIF-1 (zeige HIF1A Proteine)-dependent pathway. IL-6 produced by hypoxic articular chondrocytes stimulates inflammatory cytokine responses in synovial cells.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (zeige TGFB1 Proteine), IL-10 (zeige IL10 Proteine), and IL-6 in ovarian follicles are reported.
Data suggest IL6 prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst viability via IL6/STAT3 (zeige STAT3 Proteine) (signal transducer/activator of transcription (zeige STAT1 Proteine) 3) signaling pathway (including up-regulation of STAT3 (zeige STAT3 Proteine) expression/phosphorylation).
LIF (zeige LIF Proteine) and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.
INFgamma and IL-6 modulate PPARs gene expression in the porcine endometrium during the estrous cycle and pregnancy.
interleukin-6, endothelin ET-1 (zeige EDN1 Proteine), and apoptotic Bak (zeige BAK1 Proteine) and Bcl-XL (zeige BCL2L1 Proteine) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Data show that all five molecules, BNP, ICAM-1 (zeige ICAM1 Proteine), TNF-alpha (zeige TNF Proteine), VCAM-1 (zeige VCAM1 Proteine) and IL-6, quickly and reliably signaled adverse interactions.
IL-6 level from frozen peripheral blood mononuclear cells was significantly lower than that from fresh ones.
These results suggest that TNF-alpha (zeige TNF Proteine) and IL-10 (zeige IL10 Proteine), but not IL-6, are involved in the late reparatory phases of the experimental disk lesion.
Plasma nitric oxide acts as a regulator of cytokine function exhibiting negative feedback to maintain steady plasma IL-6 concentration in protein- or energy-restricted goats during late gestation.
These data suggest that IL-6 may play a key role in equine metabolic syndrome (EMS), and that pro-inflammatory cytokines levels in serum may serve as an additional tool for diagnosing EMS.
IL-6 stimulation decreased chondrocyte expression of the canonical Wnt (zeige WNT2 Proteine) signaling pathway transactivator beta-catenin (zeige CTNNB1 Proteine), induced expression of inhibitors of the Wnt (zeige WNT2 Proteine) pathway, and increased expression of GDF-5 (zeige GDF5 Proteine).
study shows that IL-6 is rapidly induced in BAL-cells of airway-compromised horses in response to adenosine exposure, probably through A2BAR (zeige ADORA2B Proteine) activation and that this effect can be modulated by A2AAR (zeige ADORA2A Proteine)
Our data show the presence of a polymorphism downstream of the equine IL-6 gene that is associated with the basal Cu:Zn ratio in horses independent of breed.
Expression levels of IL-6 are significantly increased in peripheral blood mononuclear cells from trained horses compared to sedentary animals.
Failure of passive transfer may directly influence the serum IL-6 concentration in septic foals. Neither serum IL-6 nor IL-10 (zeige IL10 Proteine) alone, were useful diagnostic indices of sepsis in equine neonates.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 (zeige IL10 Proteine) and TNF-alpha (zeige TNF Proteine), in horses with recurrent airway obstruction during exacerbation and in remission is reported.
IL6 mRNA abundance was significantly increased in spleen, liver, and gill of rainbow trout after experimental infection with Aeromonas salmonicida.
in this paper we present for the first time in fish the functional characterisation of IL-6, using rainbow trout
found that peptidoglycans derived from Gram-negative bacteria (Escherichia coli 0111:B4 and K12 (zeige KRT12 Proteine)), are potent inducers of IL-1beta (zeige IL1B Proteine) and IL-6 gene expression and were equal to, or more potent than, crude LPS (zeige IRF6 Proteine).
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
B-cell hybridoma growth factor
, interleukin HP-1
, Interleukin 6 (interferon, beta 2)
, B-cell differentiation factor
, B-cell stimulatory factor 2
, CTL differentiation factor
, hybridoma growth factor
, interferon beta-2
, interleukin BSF-2
, interleukin-6 protein