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these results suggest that Helicobacter pylori lipopolysaccharide induces TLR2 expression in the gastric adenocarcinoma cells, and that the longer the exposure to lipopolysaccharide, the greater the expression of TLR2 in the cell membrane; consequently the expression of claudin-4 (zeige CLDN4 Proteine), -6, -7 and -9 also increases
Cycling hypoxia could induce significant changes in CLDN1 (zeige CLDN1 Proteine) and CLDN7 expression in nasopharyngeal cancer cells, indirectly regulation P18 (zeige CDKN2C Proteine) expression and affecting cell invasion/proliferation.
These results identify EpCAM (zeige EPCAM Proteine) as a substrate of matriptase (zeige ST14 Proteine) and link HAI-2 (zeige SPINT2 Proteine), matriptase (zeige ST14 Proteine), EpCAM (zeige EPCAM Proteine), and claudin-7 in a functionally important pathway that causes disease when it is dysregulated.
84/118, 64/118, 52/118 reaction with claudin-1, claudin-3 (zeige CLDN3 Proteine) and claudin-4 (zeige CLDN4 Proteine) in cancer and colon polyps had a membrane localization, respectively.Mislocalization claudin-3 (zeige CLDN3 Proteine) to nucleus in colon cancer and mislocalization claudin-4 (zeige CLDN4 Proteine) to nucleus in adenomas of the colon were detected for the first time.
suggest that the reduction of CLDN5 (zeige CLDN5 Proteine), 7, and 18 expression loses the suppressive ability of interaction between PDK1 (zeige PDK1 Proteine) and Akt (zeige AKT1 Proteine) and causes sustained phosphorylation of Akt (zeige AKT1 Proteine), resulting in the disordered proliferation in lung squamous carcinoma cells
These results suggested that increase of Cldn4 (zeige CLDN4 Proteine)-expression may be involved in early molecular events during carcinogenesis of adenocarcinoma, whereas increase of Cldn7-expression may be associated with tumor invasion or progression.
that the dysregulated expression of these miRNAs, in conjunction with the high claudin 1 levels, could serve as a useful biomarker that identifies a subset of tumors within the poorly characterized basal-like subtype of breast cancer
localization of Cldn3 (zeige CLDN3 Proteine), Cldn7 and Cldn10 (zeige CLDN10 Proteine) proteins in the different compartments of murine endometrium up to day 8.5 of pregnancy (dpc) as well as in human endometrium and first trimester decidua
The expression of claudin-7 has no obviously difference between cervical carcinoma tissues and adjacent non-neoplastic tissues.
We identified hepatocyte nuclear factor 4alpha as a regulatory factor that bound endogenous CLDN7 promoter in differentiating intestinal epithelial cells and stimulated CLDN7 promoter activity.
Intestinal Cldn7 deletion initiated inflammation and hyperplasia in mice.
Data show that claudin-4 (zeige CLDN4 Proteine) and claudin-7 were observed in hepatocytes of severely damaged mouse and human livers.
The intestine-specific Cldn7 deficiency caused colonic inflammation, even though TJ structures were still present due to other claudins.
Salmonella targets the tight junction protein (zeige OCLN Proteine) claudin-2 (zeige CLDN2 Proteine) to facilitate bacterial invasion.
In mice, claudin-7 has non-TJ functions, including maintenance of epithelial cell-matrix interactions and intestinal homeostasis.
TSLP (zeige TSLP Proteine) induces expression of tight junction protein (zeige OCLN Proteine) claudin-7 in dendritic cells via NF-kappaB (zeige NFKB1 Proteine) as well as via TLRs and may control tight junctions of DCs to preserve the epithelial barrier during allergic inflammation
Claudin-7 is essential for NaCl homeostasis in distal nephrons, and the paracellular ion transport pathway plays indispensable roles in keeping ionic balance in kidneys.
claudin-7 was found in the same nephron segments as claudin-8 (zeige CLDN8 Proteine), but it was expressed primarily at the basolateral membrane
Tumor necrosis factor-alpha (zeige TNF Proteine) increases claudin-1 (zeige CLDN1 Proteine), 4, and 7 expression in renal tubular cells, altering permeability and transepithelial electrical resistance.
the effect of claudin-7 overexpression in LLC-PK1 cells on paracellular transport is mediated through a concurrent decrease in the paracellular conductance to Cl(-) and an increase in the paracellular conductance to Na(+).
These findings indicate that claudin-4 (zeige CLDN4 Proteine) and -7 may play a role in the gingiva junctional epithelium even in the absence of tight junctions.
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.
, claudin-like protein ZF4A22
, clostridium perfringens enterotoxin receptor-like 2