anti-Maus SUFUH Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended SUFUH Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Suppressor of Fused Homolog (Drosophila) (SUFUH) Antikörper
  • CG6054
  • Dmel\\CG6054
  • SU(FU)
  • SUFU
  • Su(Fu)
  • SuFu
  • Sufu
  • su(fu)
  • sufu
  • Xsufu
  • sufuh
  • sufuxl
  • PRO1280
  • SUFUH
  • SUFUXL
  • Su(fu)
  • dre
  • fi39e05
  • wu:fi39e05
  • 2810026F04Rik
  • b2b273Clo
  • Suppressor of fused
  • SUFU negative regulator of hedgehog signaling L homeolog
  • SUFU negative regulator of hedgehog signaling
  • suppressor of fused homolog (Drosophila)
  • Su(fu)
  • sufu.L
  • SUFU
  • sufu
  • Sufu
Reaktivität
Human, Maus, Ratte (Rattus)
66
38
34
7
7
7
7
4
3
3
3
3
2
1
Wirt
Kaninchen
61
3
2
Klonalität
Polyklonal
Konjugat
Dieser SUFUH Antikörper ist unkonjugiert
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
40
22
14
12
11
6
3
2
2
2
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN1386317
$ 306.90
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN959031 IHC IHC (p) WB Rabbit C-Term Anmelden zum Anzeigen Polyclonal 0
1 ABIN4356971 ICC IF IHC IHC (p) WB Rabbit IgG Center Anmelden zum Anzeigen Polyclonal 0
1 ABIN1407812 IHC (p) HRP Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN1389919 IHC (p) Biotin Rabbit IgG Anmelden zum Anzeigen Polyclonal 0

General

Antigen Suppressor of Fused Homolog (Drosophila) (SUFUH) Antikörper
Reaktivität Human, Maus, Ratte (Rattus)
(66), (38), (34), (7), (7), (7), (7), (4), (3), (3), (3), (3), (2), (1)
Wirt Kaninchen
(61), (3), (2)
Klonalität
Polyklonal
Konjugat Dieser SUFUH Antikörper ist unkonjugiert
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(40), (22), (14), (12), (11), (6), (3), (2), (2), (2), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-SUFUH Antikörper

Target Details SUFUH Anwendungsinformationen Handhabung Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human SUFU
Isotyp IgG
Plasmids, Primers & others

Target Details SUFUH

Produktdetails anti-SUFUH Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung SUFU/Suppressor of Fused (SUFUH Antibody Abstract)
Hintergrund

Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity).

Subcellular location: Cytoplasm, Nucleus

Synonyms: SUFUH, SUFUXL, PRO1280, Suppressor of fused homolog, SUFU, UNQ650/PRO1280

Gen-ID 51684
UniProt Q9UMX1
Pathways Hedgehog Signalweg, Tube Formation, Maintenance of Protein Location

Anwendungsinformationen

Produktdetails anti-SUFUH Antikörper Target Details SUFUH Handhabung Bilder zurück nach oben
Applikations-hinweise IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-SUFUH Antikörper Target Details SUFUH Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Bilder

Produktdetails anti-SUFUH Antikörper Target Details SUFUH Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Suppressor of Fused Homolog (Drosophila) (SUFUH) antibody (ABIN1386317) Lane 1:Mouse intestine lysate Lane 2: Mouse lung lysate Lane 3: Mouse brain probed wi...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Suppressor of Fused Homolog (Drosophila) (SUFUH) antibody (ABIN1386317) Formalin-fixed and paraffin embedded mouse embryo labeled with Anti-SUFU/Suppressor o...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Suppressor of Fused Homolog (Drosophila) (SUFUH) antibody (ABIN1386317) Formalin-fixed and paraffin embedded rat brain labeled with Anti-SUFU/Suppressor of F...