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Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validierenRelevance Score | ABIN | Application | Konjugat | Host | Isotype | Epitope | Hersteller | Clonality | References | Details |
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7 | ABIN959031 | IHC IHC (p) WB | Rabbit | C-Term | Anmelden zum Anzeigen | Polyclonal | 0 | |||
7 | ABIN1739762 | IHC (p) | Goat | AA 2-13, N-Term | Anmelden zum Anzeigen | Polyclonal | 0 | |||
1 | ABIN1407812 | IHC (p) | HRP | Rabbit | IgG | Anmelden zum Anzeigen | Polyclonal | 0 | ||
1 | ABIN1389919 | IHC (p) | Biotin | Rabbit | IgG | Anmelden zum Anzeigen | Polyclonal | 0 | ||
1 | ABIN6244107 | IHC (p) WB | Mouse | IgG1, kappa | Anmelden zum Anzeigen | 1783CT536-263-29 | 0 | |||
-12.769841 | ABIN4356971 | ICC IF IHC IHC (p) WB | Rabbit | IgG | Center | Anmelden zum Anzeigen | Polyclonal | 0 |
General |
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Antigen | Suppressor of Fused Homolog (Drosophila) (SUFUH) Antikörper |
Reaktivität | Human, Maus, Ratte (Rattus) Alternativen |
Wirt | Kaninchen Alternativen |
Klonalität | |
Konjugat | Dieser SUFUH Antikörper ist unkonjugiert Alternativen |
Applikation |
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Alternativen
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Hersteller | Anmelden zum Anzeigen |
Produktdetails anti-SUFUH AntikörperTarget Details SUFUH Anwendungsinformationen Handhabung Bilder |
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Reinigung | Purified by Protein A. |
Immunogen | KLH conjugated synthetic peptide derived from human SUFU |
Isotyp | IgG |
Plasmids, Primers & others | |
Target Details SUFUHProduktdetails anti-SUFUH Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben |
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Antigen | |
Andere Bezeichnung | SUFU/Suppressor of Fused (SUFUH Antibody Abstract) |
Hintergrund |
Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity). Subcellular location: Cytoplasm, Nucleus Synonyms: SUFUH, SUFUXL, PRO1280, Suppressor of fused homolog, SUFU, UNQ650/PRO1280 |
Gen-ID | 51684 |
UniProt | Q9UMX1 |
Pathways | Hedgehog Signalweg, Tube Formation, Maintenance of Protein Location |
AnwendungsinformationenProduktdetails anti-SUFUH Antikörper Target Details SUFUH Handhabung Bilder zurück nach oben |
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Applikations-hinweise |
IHC-P 1:100-500 IF(IHC-P) 1:50-200 |
Beschränkungen | Nur für Forschungszwecke einsetzbar |
HandhabungProduktdetails anti-SUFUH Antikörper Target Details SUFUH Anwendungsinformationen Bilder zurück nach oben |
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Format | Liquid |
Konzentration | 1 μg/μL |
Buffer | Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide. |
Konservierungs-mittel | Sodium azide |
Vorsichtsmaßnahmen | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only. |
Lagerung | -20 °C |
Informationen zur Lagerung | Store at -20°C |
Haltbarkeit | 12 months |
BilderProduktdetails anti-SUFUH Antikörper Target Details SUFUH Anwendungsinformationen Handhabung zurück nach oben |
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Bilder des Herstellers |