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The results of this study shown the Upregulated Expression of Heparanase in the Brains of Alzheimer's Disease.
Heparanase has a role in upregulating platelet adhesion activity and thrombogenicity
Results show that all tested inhibitors reduced heparanase (HPA) enzyme activity and inhibited the growth of HeLa cells.
Data demonstrate that the mesenchymal features induced by HPSE in MM cells contribute to enhanced tumor cell motility and bone-dissemination.
c-Myc (zeige MYC Proteine) and heparanase expression was positively correlated with hTERT levels, and was also an independent predictor of metastasis and survival.
miR (zeige MLXIP Proteine)-558 facilitates the progression of gastric cancer through directly targeting the HPSE promoter to attenuate Smad4 (zeige SMAD4 Proteine)-mediated repression of HPSE expression.
High HPSE expression is associated with breast carcinoma.
data suggest that heparanase plays a critical role in NK cell invasion into tumors and thereby tumor progression and metastases.
The heparanase/syndecan1 (zeige SDC1 Proteine) axis in gallbladder carcinoma cells plays an important role in the invasion and metastasis, thus providing a new therapeutic target.
Results show that HPSE is upregulated in human glioma and seems to confer a growth advantage on glioma cells.
Results demonstrate that acute ischemic injury up-regulates renal heparanase expression and suggest that heparanase plays a deleterious role in the development of renal injury and kidney dysfunction.
eNOS (zeige NOS3 Proteine) prevents heparanase induction and the development of proteinuria
Data show that heparanase-1 (HPA-1) induced shedding of heparan sulfate chain from syndecan-1 (SDC-1 (zeige SDC1 Proteine)) facilitated the release of vascular endothelial growth factor C (VEGF-C (zeige VEGFC Proteine)) from SDC-1 (zeige SDC1 Proteine)/VEGF-C (zeige VEGFC Proteine) complex into the medium of hepatocarcinoma cell.
the activation of intestinal heparanase contributes to intestinal injury during early sepsis by facilitating the destruction of mucosal epithelial glycocalyx and promoting inflammatory responses.
Heparanase increases the inflammation in AGEs-stimulated macrophages through activating the RAGE (zeige AGER Proteine)-NF-kappaB (zeige NFKB1 Proteine) pathway. Heparanase driven inflammation from AGEs-stimulated macrophages increases the adherence of glomerular endothelial cells (GEnCs) and augments the permeability of GEnCs.
heparanase contributes to allergen-induced eosinophil recruitment to the lung.
Unfractionated heparin inhibits heparanase, and reverses the activation of NF-kappaB (zeige NFKB1 Proteine) and MAPK P38 (zeige MAPK1 Proteine) signaling pathways to attenuate inflammatory responses induced by sepsis. These results suggest that UFH
Results show a critical role for heparanase in regulating the branching and invasive behavior of normal mammary epithelia which could be the result of its mutually reciprocal feedback with MMP-14 (zeige MMP14 Proteine).
Data suggest a potential mechanism of diabetic enteropathy, which is depending remarkably on syndecan-1 (Sdc1 (zeige SDC1 Proteine)) and -beta-D-glucuronidase (zeige GUSB Proteine) heparanase (HPSE).
These data suggest that porcine reproductive and respiratory syndrome virus activates NF-kappaB (zeige NFKB1 Proteine) and cathepsin L to upregulate and process heparanase, and then the active heparanase cleaves heparan sulfate, resulting in viral release.
during late gestation, the mRNA and HPSE levels were higher in Meishan placentae than Yorkshire pigs
study of tissue expression profiles, polymorphisms of HPSE and HPSE2 genes and changes of their mRNA levels in porcine alveolar macrophages (PAMs) induced by PRRSV; upon stimulation in healthy piglets with PRRSV, HPSE mRNA was obviously upregulated, while HPSE2 mRNA did not induce a prominent change in PAMs
our results support a critical role for heparanase in the development of vulnerable atherosclerotic plaques
report molecular cloning and characterisation of heparanase mRNA in the porcine placenta throughout gestation.
Suggest that high glucose is a potent stimulator of endothelial heparanase secretion.
Lutropin (zeige LHB Proteine) induces a transient increase in HPSE mRNA at specific times after its addition.
Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.
, endoglycosidase heparanase