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Single nucleotide polymorphism in NEGR1 gene is associated with major depressive disorder.
Significant associations were identified at 3.5 years old for TMEM18 (zeige TMM18 ELISA Kits) rs6548238, NEGR1 rs2815752, BDNF (zeige BDNF ELISA Kits) rs10767664 and rs6265 (1 year old and 3.5 years old) with anthropometric phenotypes
NEGR1 interacts with NPC2 (zeige NPC2 ELISA Kits) and increases its protein stability; it has a role in obesity
We observed novel selection signals in CDKAL1 (zeige CDKAL1 ELISA Kits) and NEGR1, well-known diabetes and obesity susceptibility genes
NEGR1 could be an important locus influencing certain personality dimensions in BN patients.
First study to find an association between an obesity risk gene and differences in white matter integrity. As our subjects were young and healthy, our results suggest that NEGR1 has effects on brain structure independent of its effect on obesity.
Data indicate strong associations with severe obesity for single nucleotide polymorphism (SNP) rs9939609 within the FTO (zeige FTO ELISA Kits) gene and SNP rs2815752 near the NEGR1 gene.
Results imply a regulatory role for TMEM18 (zeige TMM18 ELISA Kits), BDNF (zeige BDNF ELISA Kits), MTCH2 (zeige MTCH2 ELISA Kits) and NEGR1 in adipocyte differentiation and biology. In addition, we show a variation of MAF (zeige MAF ELISA Kits) expression during adipogenesis, while NPC1 (zeige NPC1 ELISA Kits), PTER (zeige PTER ELISA Kits) and SH2B1 (zeige SH2B1 ELISA Kits) were not regulated.
Our study supports earlier reports of SH2B1 (zeige SH2B1 ELISA Kits) to be of importance in insulin (zeige INS ELISA Kits) sensitivity and, in addition, suggests potential roles of NEGR1 and MTCH2 (zeige MTCH2 ELISA Kits).
Meta-analysis of 4992 subjects revealed seven SNPs near four loci, including NEGR1, TMEM18 (zeige TMM18 ELISA Kits), SH2B1 (zeige SH2B1 ELISA Kits) /ATP2A1 (zeige ATP2A1 ELISA Kits) and MC4R (zeige MC4R ELISA Kits), showing significant association at 0.005
The long non-coding RNA, BC048612, and microRNA-203 were determined to be positive and negative regulators of Negr1 gene expression respectively.
Negr1 controls the development of neurite arborization in vitro and in vivo.
a role of NEGR1 in the control of body weight and food intake
These results suggest a function for neurotractin/kilon as a trans-neural growth-promoting factor for outgrowing axons following hippocampal denervation.
glycosylphosphatidylinositol-anchored cell adhesion protein
neuronal growth regulator 1
, neuronal growth regulator 1-like
, IgLON family member 4
, a kindred of IgLON
, kindred of IgLON
, kilon protein