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Human NR4A3 Protein expressed in Wheat germ - ABIN1312985
Medunjanin, Daniel, Weinert, Dutzmann, Burgbacher, Brecht, Bruemmer, Kähne, Naumann, Sedding, Zuschratter, Braun-Dullaeus: DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1. in Cardiovascular research 2015
NOR1 upregulation is associated with hypoxia-induced pulmonary vascular remodeling in COPD via promoting human pulmonary arterial smooth muscle cell proliferation.
aberrant JAK/STAT3 signaling epigenetically silences a potential tumor suppressor, NR4A3, in gastric cancer, plausibly representing a reliable biomarker for gastric cancer prognosis
NOR1 activates HSCs and contributes to liver fibrosis in vitro and this effect was achieved through the activation of the Wnt/betacatenin pathway.
In the 3 cases of the primary extraskeletal myxoid chondrosarcoma (EMC) of bone we found the most frequent and specific chromosomal translocation t(9:22) EWSR1-NR4A3 of the extraskeletal counterpart.
Results indicate that NOR-1 regulate SMPX in human muscle cells and acts as a muscle regulatory factor to promote myotube differentiation.
NR4A sub-family of nuclear orphan receptors (Nor-1, Nurr-1 and Nur-77) may have a role in trophoblastic cell differentiation.
VTN levels were increased in cell supernatants from vascular smooth muscle cells that overexpress NOR-1
NR4A2 and NR4A3 are components of a downstream transcriptional response to PKA activation in the neutrophil, and that they positively regulate neutrophil survival and homeostasis.
NOR1 suppresses cancer stem-like cell properties in nasopharyngeal carcinoma cells by inhibiting the AKT-GSK-3beta-Wnt/beta-catenin-ALDH1A1 signaling circuit.
Transcript analysis of four different aggressive lymphoma cell lines overexpressing either NR4A3 or NR4A1 revealed that apoptosis was driven similarly by induction of BAK, Puma, BIK, BIM, BID, and Trail. Overall, our results showed that NR4A3 possesses robust tumor suppressor functions of similar impact to NR4A1 in aggressive lymphomas
Study found a marked down-regulated gene expression of the NR4A subfamily (NR4A1, NR4A2, and NR4A3) obtained from Parkinson's disease patients, but only a NR4A1 decrease in Alzheimer's disease patients compared to healthy controls. This study reports that the entire NR4A subfamily and not only NR4A2 could be systemically involved in Parkinson's disease.
the role of intragenic DNA hypermethylation in reducing the expression of NR4A3 in AML
Overexpression of NR4A3 in adipocytes produces a complex phenotype characterized by impaired glucose metabolism and low serum catecholamines due to enhanced degradation by adipose tissue.
NOR1 promotes the progression of hepatocellular carcinoma cells by activating Notch pathway.
accumulation of NR4A3 is specific to alpha-synucleinopathy.
miR-17 and -20a target NOR-1 thereby regulating NOR-1-dependent gene expression.
NR4A2 is a key factor in multiple diseases, such as inflammation, cancer and cardiovascular diseases.
Identified Nur77/Nor1 as novel regulators of thrombomodulin expression and function in vascular endothelial cells.
Data identify NOR1 as a transcription factor induced during alternative differentiation of human macrophages and demonstrate that NOR1 modifies the alternative macrophage phenotype.
A2M is expressed in the vasculature and NR4A receptors modulate VSMC MMP2/9 activity by several mechanisms including the up-regulation of A2M.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene.
chondrosarcoma, extraskeletal myxoid, fused to EWS
, mitogen-induced nuclear orphan receptor
, neuron-derived orphan receptor 1
, nuclear hormone receptor NOR-1
, nuclear receptor subfamily 4 group A member 3
, translocated in extraskeletal chondrosarcoma
, neural orphan receptor 1
, orphan nuclear receptor TEC
, neuron-derived orphan receptor 1/2
, nuclear hormone receptor NOR-1/NOR-2
, nuclear receptor subfamily 4, group A, member 3
, neural orphan nuclear receptor NOR1