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Human NR4A3 Protein expressed in Wheat germ - ABIN1312985
Medunjanin, Daniel, Weinert, Dutzmann, Burgbacher, Brecht, Bruemmer, Kähne, Naumann, Sedding, Zuschratter, Braun-Dullaeus: DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1. in Cardiovascular research 2015
Long non-coding RNA BRE-AS1 represses non-small cell lung cancer cell growth and survival via up-regulating NR4A3
NR4A3 is a novel target of p53 that contributes to apoptosis
findings indicated that cAMP-PKA up-regulated STAT5B, followed by increase in syncytin2 expression through GCM1 and OVOL1, resulting in cell fusion and hCG production, while cAMP-PKA-up-regulated NR4A3 could decrease syncytin2 expression.
It has been concluded that NR4A3 is upregulated through enhancer hijacking and has important oncogenic functions in acinic cell carcinomas of the salivary glands.
NOR1 upregulation is associated with hypoxia-induced pulmonary vascular remodeling in COPD via promoting human pulmonary arterial smooth muscle cell proliferation.
aberrant JAK/STAT3 signaling epigenetically silences a potential tumor suppressor, NR4A3, in gastric cancer, plausibly representing a reliable biomarker for gastric cancer prognosis
NOR1 activates HSCs and contributes to liver fibrosis in vitro and this effect was achieved through the activation of the Wnt/betacatenin pathway.
In the 3 cases of the primary extraskeletal myxoid chondrosarcoma (EMC) of bone we found the most frequent and specific chromosomal translocation t(9:22) EWSR1-NR4A3 of the extraskeletal counterpart.
Results indicate that NOR-1 regulate SMPX in human muscle cells and acts as a muscle regulatory factor to promote myotube differentiation.
NR4A sub-family of nuclear orphan receptors (Nor-1, Nurr-1 and Nur-77) may have a role in trophoblastic cell differentiation.
VTN levels were increased in cell supernatants from vascular smooth muscle cells that overexpress NOR-1
NR4A2 and NR4A3 are components of a downstream transcriptional response to PKA activation in the neutrophil, and that they positively regulate neutrophil survival and homeostasis.
NOR1 suppresses cancer stem-like cell properties in nasopharyngeal carcinoma cells by inhibiting the AKT-GSK-3beta-Wnt/beta-catenin-ALDH1A1 signaling circuit.
Transcript analysis of four different aggressive lymphoma cell lines overexpressing either NR4A3 or NR4A1 revealed that apoptosis was driven similarly by induction of BAK, Puma, BIK, BIM, BID, and Trail. Overall, our results showed that NR4A3 possesses robust tumor suppressor functions of similar impact to NR4A1 in aggressive lymphomas
Study found a marked down-regulated gene expression of the NR4A subfamily (NR4A1, NR4A2, and NR4A3) obtained from Parkinson's disease patients, but only a NR4A1 decrease in Alzheimer's disease patients compared to healthy controls. This study reports that the entire NR4A subfamily and not only NR4A2 could be systemically involved in Parkinson's disease.
the role of intragenic DNA hypermethylation in reducing the expression of NR4A3 in AML
Overexpression of NR4A3 in adipocytes produces a complex phenotype characterized by impaired glucose metabolism and low serum catecholamines due to enhanced degradation by adipose tissue.
NOR1 promotes the progression of hepatocellular carcinoma cells by activating Notch pathway.
accumulation of NR4A3 is specific to alpha-synucleinopathy.
miR-17 and -20a target NOR-1 thereby regulating NOR-1-dependent gene expression.
NOR-1 plays a crucial role in regulating sperm count and male fertility.
These results establish crucial residues in Bcl-2 required for Nur77/Nor-1-mediated apoptosis and point to potential new strategies for manipulating Bcl-2 function.
results reveal a novel coordinate control of HSC quiescence by NR4A1/3 through direct activation of C/EBPalpha and suppression of activation of NF-kappaB-driven proliferative inflammatory responses.
NOR1 deletion induced differential inflammatory gene transcription in macrophages but did not influence abdominal aortic aneurysm formation.
Nor-1 expression drives multiple physiological changes/pathways that are critical to the beneficial responses of muscle to exercise.
these results show that NR4A3 is involved in TLR-mediated activation and gene expression of dendritic cells
NR4A3 plays an important role in the regulation of CD103+ mDCs by regulating CCR7-dependent cell migration.
Study shows that NOR-1 can transduce survival signals in neuronal cells responsible for hypoxiainduced apoptotic insults through activation of a CREB/cIAP2-dependent mechanism
Nuclear receptors of the NR4a family are not required for the development and function of follicular T helper cells
Promoting Liver X receptor-alpha expression inhibits lipopolysaccharide induced inflammation in Kupffer cells through elevating NOR-1 expression.
Identified Nur77/Nor1 as novel regulators of thrombomodulin expression and function in vascular endothelial cells.
Nr4a3 factor plays crucial role regulatory T cells, mediating the two defining characteristics of regulatory T cells: stability of cell lineage and immunosuppressive functions.
Studies demonstrate that NOR1 deletion in hematopoietic stem cells accelerates atherosclerosis formation by promoting myelopoiesis in the stem cell compartment and by inducing local proatherogenic activities in the macrophage.
Our data support a role for NOR-1 as a negative modulator of the acute response elicited by pro-inflammatory stimuli in the vasculature.
Results indicate that DNA hypomethylation of the CpG island at Nr4a3 exon 3 is associated with low Nr4a3 expression, and correlates with poor prognosis of neuroblastoma.
Skeletal muscle-specific Nor-1 expression regulates genes and pathways that regulate adiposity, muscle fiber type metabolic capacity, and endurance.
NR4A nuclear receptors are involved in negative selection of thymocytes, Treg differentiation and the development of Ly6C monocytes. Nur77 and Nurr1 attenuate atherosclerosis in mice whereas NOR-1 aggravates vascular lesion formation.
Results indicate mutual antagonism between neuron-derived orphan receptor 1 (NOR1) and glucocorticoid receptor (GR) to be a key rheostat for peripheral metabolic signals to centrally control energy balance.
Over-expression of neuron-derived orphan receptor-1 (NOR-1) exacerbates neointimal hyperplasia after vascular injury
Insulin-mediated AKT phosphorylation was increased by NR4A3 hyperexpression and decreased following shRNA NR4A3 suppression.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene.
chondrosarcoma, extraskeletal myxoid, fused to EWS
, mitogen-induced nuclear orphan receptor
, neuron-derived orphan receptor 1
, nuclear hormone receptor NOR-1
, nuclear receptor subfamily 4 group A member 3
, translocated in extraskeletal chondrosarcoma
, neural orphan receptor 1
, orphan nuclear receptor TEC
, neuron-derived orphan receptor 1/2
, nuclear hormone receptor NOR-1/NOR-2
, nuclear receptor subfamily 4, group A, member 3
, neural orphan nuclear receptor NOR1