Factor 12 Heavy Chain Antikörper
(Factor 12 Heavy Chain (F12))
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008].
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Ausgewählte Factor 12 Heavy Chain Kategorien
Factor 12 Heavy Chain Antikörper
High quality antibodies with extensive validation data.
Empfohlene Factor 12 Heavy Chain Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IF (p), IHC (p)
Validierungen
- (2)
Kat. Nr.
ABIN1387090
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (1)
Kat. Nr.
ABIN3181837
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC
Validierungen
Kat. Nr.
ABIN3181836
Menge
100 μL
Datenblatt
Datenblatt
Synonyme und alternative Namen zu Factor 12 Heavy Chain
coagulation factor XII (F12), coagulation factor XII (Hageman factor) (F12), FXII, HAE3, HAEX, HAFBezeichner auf Proteinebene für Factor 12 Heavy Chain
- coagulation factor XII
- factor XII
- hageman factor
- Hageman factor
- beta-factor XIIa part 1
- beta-factor XIIa part 2
- coagulation factor XIIa heavy chain
- coagulation factor XIIa light chain
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