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FADD Produkte

(Fas (TNFRSF6)-Associated Via Death Domain (FADD))

Kategorien

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008].

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Ausgewählte FADD Kategorien

FADD Antikörper

High quality antibodies with extensive validation data.

FADD ELISA Kits

Reliable ELISA kits for a wide range of species.

FADD Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene FADD Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, IHC, IP, ICC
Validierungen
  • (5)
Kat. Nr. ABIN7439960
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IP
Validierungen
  • (1)
  • (4)
Kat. Nr. ABIN6140432
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, ELISA, FACS
Validierungen
  • (4)
Kat. Nr. ABIN7193411
Menge 0.1 mg
Datenblatt Datenblatt

Empfohlene FADD ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6966647
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6955701
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method Qualitative Cell ELISA
Validierungen
Kat. Nr. ABIN1380874
Menge 2 x 96 tests
Datenblatt Datenblatt

Empfohlene FADD Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
  • (1)
Kat. Nr. ABIN1353355
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN667076
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1353353
Menge 10 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren FADD Produkten

Lindstrom, Sigurdardottir, Zapadka, Tang, Liu, Taylor, Smith, Lee, DeAngelis, Kern, Taylor: "Diabetes induces IL-17A-Act1-FADD-dependent retinal endothelial cell death and capillary degeneration." in: Journal of diabetes and its complications, Vol. 33, Issue 9, pp. 668-674, (2019) (PubMed).

Li, Mo, Lei, Li, Fu, Huang, Luo, Zhang: "Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain damage rat model via suppression of TRAIL signaling pathway." in: The international journal of biochemistry & cell biology, Vol. 99, pp. 169-177, (2018) (PubMed).

Cai, Lv, Kaldybayeva, Zhamilya, Wu, Wu: "15, 16-Dihydrotanshinone I Inhibits Hemangiomas through Inducing Pro-apoptotic and Anti-angiogenic Mechanisms in Vitro and in Vivo." in: Frontiers in pharmacology, Vol. 9, pp. 25, (2018) (PubMed).

Tian, Yao, Yang, Ren, Jiao, Zhang, Li, Zhang, Xia, Qin: "D4F alleviates macrophage-derived foam cell apoptosis by inhibiting the NF-κB-dependent Fas/FasL pathway." in: Scientific reports, Vol. 7, Issue 1, pp. 7333, (2017) (PubMed).

Soni, Adebiyi: "Early septic insult in neonatal pigs increases serum and urinary soluble Fas ligand and decreases kidney function without inducing significant renal apoptosis." in: Renal failure, pp. 1-12, (2016) (PubMed).

Papoff, Trivieri, Crielesi, Ruberti, Marsilio, Ruberti: "FADD-calmodulin interaction: a novel player in cell cycle regulation." in: Biochimica et biophysica acta, Vol. 1803, Issue 8, pp. 898-911, (2010) (PubMed).

Li, Jayarama, Ganesh, Mordi, Carr, Kanteti, Hay, Prabhakar: "Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22713-22, (2010) (PubMed).

Ko, Yang, Chung, Wen, Hsu, Miaw, Hsia: "Lack of Fas-pathway gene mutations in primary resected esophageal squamous cell carcinoma." in: Chang Gung medical journal, Vol. 33, Issue 2, pp. 145-51, (2010) (PubMed).

Hindryckx, De Vos, Jacques, Ferdinande, Peeters, Olievier, Bogaert, Brinkman, Vandenabeele, Elewaut, Laukens: "Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 10, pp. 6306-16, (2010) (PubMed).

Silva, Blanton, Parrado, Melo, Morato, Reis, Dias, Castro, Vasconcelos, Goddard, Barreto, Reis, Teixeira: "Dengue hemorrhagic fever is associated with polymorphisms in JAK1." in: European journal of human genetics : EJHG, Vol. 18, Issue 11, pp. 1221-7, (2010) (PubMed).

Synonyme und alternative Namen zu FADD

Fas associated via death domain (FADD), Fas (TNFRSF6)-associated via death domain (Fadd), Fas associated via death domain (Fadd), Fas associated via death domain S homeolog (fadd.S), Fas (tnfrsf6)-associated via death domain (fadd), adaptor, fadd, MORT1, Mort1, mort1, Mort1/FADD, TNFRSF6, xfadd

Bezeichner auf Proteinebene für FADD

  • Fas-associating death domain-containing protein
  • Fas-associating protein with death domain
  • growth-inhibiting gene 3 protein
  • mediator of receptor induced toxicity
  • mediator of receptor-induced toxicity
  • protein FADD
  • FAS-associated death domain protein
  • FAS-associating death domain-containing protein
  • Fas (TNF receptor superfamily, member 6)
  • Fas-associated via death domain
  • Fas (TNFRSF6)-associated via death domain
  • Fas associated via death domain S homeolog
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