FADD Antikörper (AA 20-150)

Produktnummer ABIN7193411

Produktdetails anti-FADD Antikörper

Target: FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

Bindungsspezifität: AA 20-150

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FADD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human FADD (AA: 20-150) expressed in E. coli.

Klon: 5A6A2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB:1:500 - 1:2000, FCM:1:200 - 1:400, ELISA:1:10000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Details zu FADD

Target: FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

Andere Bezeichnung: FADD (FADD Produkte)

Synonyme: MORT1 antikoerper, Mort1/FADD antikoerper, Mort1 antikoerper, TNFRSF6 antikoerper, adaptor antikoerper, fadd antikoerper, mort1 antikoerper, xfadd antikoerper, Fas associated via death domain antikoerper, Fas (TNFRSF6)-associated via death domain antikoerper, Fas associated via death domain S homeolog antikoerper, Fas (tnfrsf6)-associated via death domain antikoerper, FADD antikoerper, Fadd antikoerper, fadd.S antikoerper, fadd antikoerper

Hintergrund:

Description: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

Aliases: GIG3, MORT1

Molekulargewicht: 23.3 kDa

Gen-ID: 8772

Pathways: Apoptose, TLR Signalweg, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades