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by performing protein profiling on isolated astrocytes we showed that an increase in astrocytic DJ-1 (zeige PARK7 Proteine) expression up-regulated a large group of proteins associated with redox regulation, inflammation and mitochondrial respiration. The majority of these proteins have also been shown to be regulated by Nrf2.
Nrf2 was activated in response to the ER stress via the PERK pathway.
Knockdown of Nrf2 paralogs perturbed glutathione redox state in zebrafish embryo. Nrf2 alone is not essential for the response and recovery of glutathione to oxidative insults.
nrf2a modulates the embryonic response to perfluorooctanesulfonic acid (PFOS), and that PPAR (zeige PPARA Proteine) signaling may play a role in the embryonic adaptive response to PFOS.
These results suggest that alpha,beta-unsaturated carbonyl entity and catechol moiety of 6S derivatives may react with the cysteine residues of Keap1 (zeige KEAP1 Proteine), disrupting the Keap1 (zeige KEAP1 Proteine)-Nrf2 complex, thereby liberating and activating Nrf2. Our findings of natural product-derived Nrf2 activators lead to design options of potent Nrf2 activators for further optimization.
These data suggest that EC from the Tripterygium wilfordii stem extract could diminish tau-GFP-induced neuronal death through the activation of Nrf2.
we concluded that Nrf2 plays a fundamental and conserved role in protection against acute sodium arsenite toxicity
Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt (zeige AKT1 Proteine) and JNK (zeige MAPK8 Proteine)/Nrf2/NQO1 (zeige NQO1 Proteine) pathway.
Bach1 (zeige BACH1 Proteine) regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (zeige BACH1 Proteine) inhibition based on its level in each tissue.
The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.
These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 (zeige HMOX1 Proteine) within these cells.
the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.
investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 (zeige HMOX1 Proteine) gene expression in aortic endothelial cells by advanced glycation end products
The results of the current study indicate that dioscin may protect against coronary heart disease by regulating oxidative stress and inflammation via Sirt1 (zeige SIRT1 Proteine)/Nrf2 and p38 MAPK (zeige MAPK14 Proteine) pathways.
Lack of Nrf2 enhances susceptibility to mycotoxin-induced kidney disease.
The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.
Inflammation, oxidative stress, and higher expression levels of Nrf2 (zeige GABPA Proteine) and NQO1 (zeige NQO1 Proteine) proteins in the airways of women chronically exposed to biomass fuel smoke.
Data suggest that NRF2/NFE2L2 promotes breast cancer progression by enhancing glycolysis through co-activation of HIF1A (zeige HIF1A Proteine); NRF2 (zeige GABPA Proteine) and HIF1A (zeige HIF1A Proteine) mRNA and protein levels are significantly up-regulated in breast cancer cells as compared to benign breast epithelial cells. (NRF2/NFE2L2 = nuclear factor erythroid 2-related factor 2; HIF1A (zeige HIF1A Proteine) = hypoxia inducible factor 1 (zeige HIF1A Proteine) subunit alpha)
Results show that NRF2 (zeige GABPA Proteine) expression is regulated by NRG1 (zeige NRG1 Proteine) in papillary thyroid cancer (PTC (zeige F9 Proteine)).
27-OH induced autophagy is dependent on the relation between nuclear factor erythroid 2 p45-related factor 2 (Nrf2)-dependent antioxidant response and p62.
evidence for a direct role of NRF2 in globin gene regulation
the CD44-NRF2 axis might be a promising therapeutic target for the control of stress resistance and survival of CD44(high) CSC population within breast tumors.
this study shows changes of NRF2 (zeige GABPA Proteine) expression levels induced by cell-free DNA in different cell types
Metabolism-dependent clonal growth of HCT15 colorectal cancer cells was induced by Nrf2 (zeige GABPA Proteine)-dependent activation of MCT1 (zeige CMA1 Proteine)-driven lactate exchange.
Here we present a proof-of-concept application for the rational design of an epitope-specific antibody binding with the target protein Keap1 (zeige KEAP1 Proteine), by grafting pre-defined structural interaction patterns from the native binding partner protein, Nrf2 (zeige GABPA Proteine), onto geometrically matched positions of a set of antibody scaffolds. The designed antibodies bind to Keap1 (zeige KEAP1 Proteine) and block the Keap1 (zeige KEAP1 Proteine)-Nrf2 (zeige GABPA Proteine) interaction in an epitope-specific way
This review focuses on some fundamental aspects of Nrf2 (zeige GABPA Proteine) effects on redox systems, mitochondrial function, and proteostasis. [Review Article]
By inhibiting binding of Keap1 (zeige KEAP1 Proteine) to Nrf2.
Our data show reduced muscle mass and contractile force generation in old Nrf2-/- mice compared to age-matched wildtype mice associated with reduced mitochondrial oxygen consumption, increased mitochondrial ROS (zeige ROS1 Proteine) production, increased protein nitrosylation, cellular redox dysregulation, and reduced acetylcholine receptor (zeige CHRNB1 Proteine) expression.
Keap1 (zeige KEAP1 Proteine)-null mice showed that differentiation of both osteoclasts and osteoblasts was attenuated, showing that impaired differentiation of osteoblasts rather than osteoclasts is responsible for bone hypoplasia caused by Nrf2 hyperactivation.
Involved in the Nrf2/HO-1 (zeige HMOX1 Proteine) pathway.
these data suggest that alleviation of the sustained mitochondrial dysfunction and oxidative stress through co-modulation of NRF2 and PINK1 (zeige PINK1 Proteine) may be in charge of restoration of the cognitive impairments in a mouse model of high-LET carbon ion irradiation
Here, the authors demonstrate that Tim-3 (zeige HAVCR2 Proteine) inhibits macrophage phagocytosis of Listeria monocytogenes by inhibiting the nuclear erythroid 2-related factor 2 (Nrf2) signaling pathway and increases bacterial burden.
these studies are the first to demonstrate that Brain ischemic preconditioning protects the blood-brain barrier against ischemic injury by generation of endogenous electrophiles and activation of the Nrf2 pathway through inhibition of Keap1 (zeige KEAP1 Proteine)- and GSK3beta-dependent Nrf2 degradation.
Thus, Nrf2 could be a critical factor for gene-environment interactions that may determine susceptibility to preterm birth.
Our findings demonstrate that reversal of methionine oxidation is required for maintenance of cellular homeostasis in the absence of increased oxidative stress. These data provide the first link between autophagy and activation of Nrf2 in the setting of MsrA (zeige MSR1 Proteine) deletion
Studied effect of Sargassum horneri (Turner) C. Agardh ethanol extract (SHE) on inflammation induced by fine dust in RAW 264.7 cells. Results suggest SHE protects the cells from oxidative stress in part by activating the nuclear factor erythroid derived 2 like 2 /heme oxygenase 1 (zeige HMOX1 Proteine) (Nrf2/HO-1 (zeige HMOX1 Proteine)) signal pathway.
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters\; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.
, nuclear factor (erythroid-derived 2)-like 2
, nuclear factor erythroid 2-related factor 2
, NF-E2-related factor 2
, NFE2-related factor 2
, nuclear factor, erythroid derived 2, like 2
, nuclear factor erythroid-derived 2-like 2
, nuclear factor erythroid 2-like 2