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Results show that both Cdc6 and Cdt1 (zeige CDT1 Proteine), when expressed in a high level, alone or in combination, were significantly associated with poorer survival in the breast cancer patient cohort. In line with this finding, the expression of Cdc6 and Cdt1 (zeige CDT1 Proteine) was upregulated in breast cancer cells compared to normal breast epithelial cells. Expression of Cdc6 and Cdt1 (zeige CDT1 Proteine) was significantly higher in ER negative breast cancer.
Results suggested that Cdc6 controls centrosome duplication in a manner independent of its recruitment of PCM (zeige PCMT1 Proteine) proteins to the centrosome.
WHSC1L1 (zeige WHSC1L1 Proteine) and H3K36me2 are enriched in the gene bodies of the cell cycle-related genes CDC6 and CDK2 (zeige CDK2 Proteine), implying that WHSC1L1 (zeige WHSC1L1 Proteine) directly regulates the transcription of these gene
Cdc6 expression is up-regulated in bladder cancer tissues and is positively correlated to high tumor grade.
PPP2R3B (zeige PPP2R3B Proteine) codes for the PR70 protein, a regulatory substrate-recognizing subunit of protein phosphatase 2A. PR70 decreased melanoma growth by negatively interfering with DNA replication and cell cycle progression through its role in stabilizing CDC6-chromatin licensing and CDT1 (zeige CDT1 Proteine) interaction
AZD7762 demonstrates synergy with regard to inhibition of AR-CDC6-ATR (zeige ANTXR1 Proteine)-Chk1 (zeige CHEK1 Proteine) signaling.
The opposing effects of ORC1 (zeige ORC1L Proteine) (represor) and CDC6 (gene activator) in controlling the level of Cyclin E (zeige CCNE1 Proteine) ensures genome stability and a mechanism for linking directly DNA replication and cell division commitment.
Data suggest that regulation of microtubule nucleation and recruitment of pericentriolar proteins to centrosome requires Cdc6 ATPase activity, as well as centrosomal localization of Cdc6.
6 overexpression may contribute to the high proliferation and low apoptosis in chronic myeloid leukemia (zeige BCL11A Proteine) cells and can be regulated by BCR/ABL (zeige ABL1 Proteine) signal transduction through downstream phosphoinositide 3-kinase/Akt (zeige AKT1 Proteine) and Janus kinase/signal transducer and activator of transcription (zeige STAT1 Proteine) pathways, suggesting cell division cycle protein 6 as a potential therapeutic target in chronic myeloid leukemia (zeige BCL11A Proteine).
the level of Cdc6 phosphorylation at serine 54 (S54P) was increased in E7-expressing cells. S54P was associated with an increase in the total amount of Cdc6 and chromatin-bound Cdc6. DNA damage-enhanced upregulation and chromatin binding of Cdc6 appeared to be due to downregulation of cyclin-dependent kinase 1 (Cdk1 (zeige CDK1 Proteine)) as Cdk1 (zeige CDK1 Proteine) knockdown increased Cdc6 levels
Dele (zeige KIAA0141 Proteine) and Cdc6 G-quadruplex formation is significant in the transcriptional regulation. Dele (zeige KIAA0141 Proteine) and Cdc6 G-quadruplex DNA alone possess enhancer and promotor function.
CDK1 (zeige CDK1 Proteine) activation proceeds with concomitant inhibition by CDC6, which tunes the timing of the M-phase entry during the embryonic cell cycle
Cdc6 continued to block apoptosome assembly induced by a non-cytochrome c (zeige CYCS Proteine) or some other mechanism, suppressing seemingly unintended apoptosis when promoting cell proliferation
show that MyoD can occupy an E-box within the promoter of Cdc6 and that this association, along with E2F3a, is required for its activity.
CDC6 is essential for spindle formation in mouse oocytes
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
CDC6 cell division cycle 6 homolog
, CDC6-related protein
, cdc18-related protein
, cell division control protein 6 homolog
, cell division cycle 6 homolog