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Results suggest that Xenopus MBD4 (zeige MBD4 Proteine)/MLH1 participates in a novel G2 checkpoint that is responsive to DNMT1p levels in developing embryos and cells.
Male mlh1 mutants are sterile and display an arrest in spermatogenesis at metaphase I, resulting in increased testis weight due to accumulation of prophase I spermatocytes.
In zebrafish mlh1 mutant (knock-out) males, a delay of both meiotic divisions occurs rather than complete arrest during meiosis I. Eggs fertilized with mutant sperm develop as malformed embryos and are aneuploid.
Identification and characterization of novel knockout mutants of the three major MMR (zeige MRC1 Proteine) genes, mlh1, msh2 (zeige MSH2 Proteine), and msh6 (zeige MSH6 Proteine), in zebrafish that develop tumors at low frequencies.
a causal relationship between MLH1-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.
high mutation ofMlh1(-/-)-deficient fetuses has little effect on the fetuses during their early developmental stages, whereas Mlh1(-/-)-deficient fetuses from X-ray irradiated mothers are clearly effected
radiation exposure could further increase the risk of colorectal carcinogenesis induced by inflammation under the conditions of Mlh1 deficiency.
these data identify Mlh1 and Mlh3 as novel critical genetic modifiers of HTT (zeige HTT Proteine) CAG instability, point to Mlh1 genetic variation as the likely source of the instability difference in B6 and 129 strains
Data indicate that Mlh1 showed only modest methylation was still expressed in both Mlh1(+/-) and Mlh1(+/+) mice.
nickel-smelting fumes upregulated the expression of Mlh1 protein, mouse . This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.
suggesting a role for the ATPase activity of MLH1 beyond the activation of the endonuclease functions of its MMR (zeige MRC1 Proteine) partner PMS2 (zeige PMS2 Proteine)
Down-regulation of MLH1 is associated with initiation and growth of neuroblastoma (zeige ARHGEF16 Proteine) and brain tumour multicellular spheroids.
MLH1 can convert DNA nicks and point mutations into double-stranded DNA breaks for both core nonhomologous end-joining factors and alternative end-joining pathways of class-switch recombination.
Data show that the constitutive inactivation of MLH1, resulting Mlh1(Deltaex4/Deltaex4) mouse line, displays complete MMR (zeige MRC1 Proteine) deficiency and a cancer predisposition phenotype similar to Mlh1-/- mice.
Analysis of expression Quantitative Trait Loci (eQTLs) provides modest support for altered regulation of MLH1 and LRRFIP2 (zeige LRRFIP2 Proteine), raising the possibility that the modifier affects regulation of both genes.
MLH1 deficiency had an impact on the evolution of the tumor after surgical resection in a murine xenograft model.
Results indicate that the normal tissue types tested (colorectum and PBMC) experience dynamic genotype-associated epigenetic alterations at the MLH1 shore, whereas cancer tumor DNA incurs aberrant hypermethylation compared to normal DNA. These results reveal that the epigenetic landscape of MLH1 is dynamically regulated at least in part by the static genetic sequence.
MLH1-methylated CpG island methylator phenotype is associated with serrated adenoma in colorectal carcinoma.
cancer-specific survival did not differ in Lynch syndrome-associated colorectal cancer (CRC (zeige CALR Proteine)) compared with MLH1-hm CRC (zeige CALR Proteine), suggesting that they carry a similar prognosis.
Data show that MLH1(L749P) and MLH1(Y750X) make PMS2 (zeige PMS2 Proteine) prone to calyculin induced degradation, suggeting that the specific degradation of PMS2 (zeige PMS2 Proteine) may represent a new mechanism to regulate MLH1-PMS2 (zeige PMS2 Proteine) heterodimer protein MutLalpha.
hMLH1 (rs1800734) AA genotype is associated with increased risk of lung cancer development.
miR (zeige MLXIP Proteine)-148b mimic sensitized A549 xenografts to irradiation in vivo Our study demonstrated that miR (zeige MLXIP Proteine)-148b regulates radioresistance of lung cancer cells by modulating MLH1 expression level. miR (zeige MLXIP Proteine)-148b may represent a new therapeutic target for the intervention of lung cancer.
hMLH1 promoter hypermethylation plays important roles in esophageal carcinoma drug-resistance
Loss of MLH1 expression is associated with colorectal carcinoma.
Meiosis progression and female age affect expression profile of DNA repair MLH1 gene in bovine oocytes.
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.
MutL protein homolog 1
, DNA mismatch repair protein Mlh1
, mutL-like protein 1
, mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
, DNA mismatch repair protein Mlh1-like
, colon cancer, nonpolyposis type 2
, mutL protein homolog 1
, mismatch repair protein 1