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Results demonstrate that cell motility and Ca(2 (zeige CA2 Proteine)+)i activity are affected by pharmacological agents that target TRPV1, indicating a novel role for this channel during cell migration.
Using knock-down studies, we also show that TRPV1 is required for normal heat-induced locomotion.
positive correlation between VR1 and PGE2 expression in leiomyoma cells and areas with pain around the tumors
5'UTR influences the stability and translation efficacy of TRPV1 transcripts, and that TRPV1 variant three (TRPV1v3) was the most stable and the only variant expressed in glioblastoma samples and in glioma stem-like cells.
Upper gastrointestinal symptoms are more common in subjects with a higher consumption of spicy foods, younger age and female gender, regardless of TRPV1 genotypes and the H. pylori infection status.
Mean TRPV-1 and TRPA-1 (zeige TRPA1 Proteine) gene expression was higher in IPF patients compared with controls, but the difference did not reach statistical significance. Immunostaining supported these findings
TRPV1 and TRPA1 (zeige TRPA1 Proteine) also act as nociceptive sensors and potentiate the inflammatory process.
studies identified TRPV4 (zeige TRPV4 Proteine) as a channel that contributes to both histamine- and chloroquine-induced itch and indicated that the function of TRPV4 (zeige TRPV4 Proteine) in itch signaling involves TRPV1-mediated facilitation.
People with the minor alleles of the TRPV1 single nucleotide polymorphisms rs161364 and rs8065080 have a lower risk of diabetes with a high-fat diet, but people with the major alleles are at a higher risk of type 2 diabetes when consuming high-fat diets.
The TRPV1 transcript was present in prostate cancer-affected foci, both in the tumor tissue as well as in the adjacent untransformed part of the gland. All breast carcinoma cell lines showed robust expression of TRPV1. Trigeminal ganglion expressed significantly higher levels of TRPV1 protein than either breast or prostate cancer cells. Ectopic expression of TRPV1 decreases cancer cell survival by induction of apoptosis.
This activity is independent of the NGF (zeige NGFB Proteine) pathway and is not mediated by known TRPV1 toxins' binding sites.
It has been shown that the propagation of the TRPV1-induced cytosolic calcium and sodium fluxes into mitochondria is dependent on coordinated activity of NCLX and MCU (zeige MCU Proteine).
Activation of TRPV1 might accelerate the development of the PAR2 (zeige F2RL1 Proteine)-triggered referred hyperalgesia in mice.
These results indicate that TRPV1 is important for activating proinflammatory STAT3 (zeige STAT3 Proteine) signaling and thermoregulation-associated brain pathways in the brain.
Dual FAAH (zeige FAAH Proteine) and TRPV1 blockage inhibits contextual fear memory.
TRPA1 (zeige TRPA1 Proteine), TRPV1 and mast cells play an indispensable role in the development of toluene-2,4-diisocyanate-elicited airway hyperreactivity
This study demonstrated that botulinum neurotoxin A doenregulation of Trpv1 in the dorsal root ganglia in mice
that the augmented expression of TRPV1 in alpha-GalA (zeige GLA Proteine)(-/0) nociceptors may underly at least in part their increased heat sensitivity
This study showed that spontaneous pain is dependent on the virulence determinant agr (zeige AGRN Proteine) and bacterial pore-forming toxins (PFTs). The cation channel, TRPV1, mediated heat hyperalgesia as a distinct pain modality.
Study suggests that deletion of TRPV1 receptors prevents reduction of hyperthermic seizure susceptibility in older mouse pups via a mechanism independent of hyperthermia-induced respiratory alkalosis, but possibly involves impaired development of thermoregulatory mechanisms, although at present, the mechanisms remain unknown.
4-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling.
Depending on the concentration, lidocaine employs TRPV1, TRPA1 (zeige TRPA1 Proteine) and intracellular Ca2 (zeige CA2 Proteine)+ stores to induce a Ca2 (zeige CA2 Proteine)+-dependent release of the neuropeptide CGRP (zeige CALCA Proteine). Lidocaine-evoked cell death does not seem to require Ca2 (zeige CA2 Proteine)+ influx through TRPV1 or TRPV1
This study is the first to shed light on the structural determinants required for the interaction between TRPV1 and evodiamine, and gives new suggestions for the rational design of novel TRPV1 ligands.
TRPV1 is expressed in cells that are particularly active in Ca(2 (zeige CA2 Proteine)) exchange as well as in cells with significant water transport activity in eyes of New Zealand White rabbits and humans
There is no correlation of expression of thromboxane A2 receptor (zeige TBXA2R Proteine) with TRPV1 in dorsal root ganglia and nodose ganglia.
HCl-induced activation of TRPV1 causes ATP release from esophageal epithelial cells that causes release of CGRP (zeige CALCA Proteine) and SP from esophageal submucosal neurons.
Capsaicin increased secretion and upregulated the expression of TRPV1 and AQP5 (zeige AQP5 Proteine) in transplanted submandibular glands.
The contractile effect of anandamide in the guinea-pig small intestine is mediated by prostanoids but not TRPV1 receptors or capsaicin-sensitive nerves.
Allergic airway inflammation can induce the expression of TRPV1 in tracheal A-fiber neurons.
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
, capsaicin receptor
, osm-9-like TRP channel 1
, transient receptor potential cation channel subfamily V member 1
, vanilloid receptor 1
, vanilloid receptor subtype 1
, vanilloid receptor type 1 like protein 1
, vanilloid type 1 receptor
, transient receptor potential vanilloid 1a
, transient receptor potential vanilloid 1b
, cation channel
, transient receptor potential cation channel V1
, transient receptor potential vanilloid type 1
, transient receptor potential V1
, vanilloid receptor-like protein