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Results demonstrate that cell motility and Ca(2 (zeige CA2 Proteine)+)i activity are affected by pharmacological agents that target TRPV1, indicating a novel role for this channel during cell migration.
Using knock-down studies, we also show that TRPV1 is required for normal heat-induced locomotion.
Disruption of the association of Sig-1R (zeige SIGMAR1 Proteine) with TRPV1 by synthetic or natural antagonists leads to degradation of TRPV1 protein and to decreased levels of the ion channel protein (zeige TRPC3 Proteine) as well as to a decrease in TRPV1-associated pain.
A strong capacity to positively regulate skin sensitization mechanisms related to the TRPV1 receptors.
Activation of TRPV1 channels attenuates ischemia-reperfusion-induced injury in a variety of organs including heart, kidney, lungs, and brain possibly via enhancing the discharge of calcitonin gene-related peptide (zeige CALCA Proteine) and substance P (zeige TAC1 Proteine)
cystinosis patients homozygous for the 57-kb deletion exhibit a strong reduction of TRPV1 function, leading to sensory deficiencies akin to the phenotype of TRPV1-deficient mice
The TRPV1 mRNA were significantly upregulated in chronic Low Back Pain compared with controls.
antitumor and apoptosis effects of 5-FU are up-regulated by activation of TRPV1 channels, but its action was down-regulated by HPer (zeige PER1 Proteine) treatment. It seems that HPer (zeige PER1 Proteine) cannot be used for increasing the antitumor effect of 5-FU through modulation of the TRPV1.
TRPV1 interacts physically with MOR-1 (zeige MDH2 Proteine) and modulates MOR-1 (zeige MDH2 Proteine) activity in HEK293 cells.
the expression of transient receptor potential vanilloid-1 (TRPV1), transient receptor potential vanilloid-2 (TRPV2 (zeige TRPV2 Proteine)) and transient receptor potential vanilloid-3 (TRPV3 (zeige TRPV3 Proteine)) channels in native human odontoblasts, was examined.
activation of TRPV1, but not TRPA1 (zeige TRPA1 Proteine) mediates a calcium-dependent cell death.
Apoptosis and oxidant effects of cisplatin were increased by activation of TRPV1 channels, but its action on the values was further increased by the ALA treatment. Combination therapy of Alpha-lipoic acid and cisplatin could be used as an effective strategy in the treatment of breast cancer.
these data revealed a target-related (i.e. capsaicin-evoked) phenotype of TRPV1 Leu206Stop mice closely resembling that of published TRPV1 knockout mice.
CuS-TRPV1 may represent a therapeutic tool to locally and temporally attenuate atherosclerosis
Trpv1 gene deletion results in excessive inflammation, exaggerates cardiac hypertrophy.
findings indicate that the initiation of the acute heat-evoked pain response in sensory nerve endings relies on three functionally redundant TRP (zeige TYRP1 Proteine) channels, representing a fault-tolerant mechanism to avoid burn injury
QLQX may improve diabetic cardiac function by regulating AGTR1/ TRPV1-mediated autophagy in STZ-induced diabetic mice.
TRPV1 increased in the dorsal root ganglion (DRG) and spinal cord (SC) at 3 weeks after CFA (zeige TBCA Proteine) injection. The expression levels of downstream molecules such as pPKA, pPI3K, and pPKC increased, as did those of pERK (zeige EIF2AK3 Proteine), pp38, and pJNK. Transcription factors (pCREB and pNFkappaB) and nociceptive ion channels (Nav1.7 (zeige SCN9A Proteine) and Nav1.8 (zeige SCN10A Proteine)) were involved in this process.
Mitochondrial modulation by all agents selectively increased cytosolic calcium in a subset of TRPA1 (zeige TRPA1 Proteine)/TRPV1-expressing (A1/V1+) neurons. There was a significant correlation between antimycin A-induced calcium responses and mitochondrial superoxide in wild-type 'responding' A1/V1+ neurons, which was eliminated in TRPA1 (zeige TRPA1 Proteine)-/- neurons, but not TRPV1-/- neurons
TRPV1 serves a protective role against myocardial apoptosis during ischemia/reperfusion via the PI3K/Akt (zeige AKT1 Proteine) signaling pathway.
We conclude that one of the possible regulatory mechanisms of TNF (zeige TNF Proteine) in mechanical orofacial hyperalgesia involves upregulation of the nociceptor TRPV1
This study is the first to shed light on the structural determinants required for the interaction between TRPV1 and evodiamine, and gives new suggestions for the rational design of novel TRPV1 ligands.
TRPV1 is expressed in cells that are particularly active in Ca(2 (zeige CA2 Proteine)) exchange as well as in cells with significant water transport activity in eyes of New Zealand White rabbits and humans
There is no correlation of expression of thromboxane A2 receptor (zeige TBXA2R Proteine) with TRPV1 in dorsal root ganglia and nodose ganglia.
HCl-induced activation of TRPV1 causes ATP release from esophageal epithelial cells that causes release of CGRP (zeige CALCA Proteine) and SP from esophageal submucosal neurons.
Capsaicin increased secretion and upregulated the expression of TRPV1 and AQP5 (zeige AQP5 Proteine) in transplanted submandibular glands.
The contractile effect of anandamide in the guinea-pig small intestine is mediated by prostanoids but not TRPV1 receptors or capsaicin-sensitive nerves.
Allergic airway inflammation can induce the expression of TRPV1 in tracheal A-fiber neurons.
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
, capsaicin receptor
, osm-9-like TRP channel 1
, transient receptor potential cation channel subfamily V member 1
, vanilloid receptor 1
, vanilloid receptor subtype 1
, vanilloid receptor type 1 like protein 1
, vanilloid type 1 receptor
, transient receptor potential vanilloid 1a
, transient receptor potential vanilloid 1b
, cation channel
, transient receptor potential cation channel V1
, transient receptor potential vanilloid type 1
, transient receptor potential V1
, vanilloid receptor-like protein