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the Bj1 RanGEF promotes Prospero nuclear export and neuroblast self-renewal
crystal structure of a complex of Drosophila RCC1 and the nucleosome core particle at 2.9 A resolution, providing an atomic view of how a chromatin protein interacts with the histone and DNA components of the nucleosome
Data show that dRCC1 is required for nuclear import of nuclear localization signal sequence (NLS)-carrying cargo molecules and for cell proliferation and/or survival during germline, eye and wing development and that dRCC1 appears to facilitate apoptosis.
This study provides first evidence for a mutation in RCC1 as a breast cancer susceptibility allele
Importin alpha3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1.
this study has demonstrated that EBNA1 and RCC1 closely associate on the chromosomes during metaphase, suggesting an essential role for the interaction during this phase, perhaps in tethering EBNA1 to mitotic chromosomes.
RCC1 expression enables the proliferation of cells that sustain DNA damage. RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence.
RCC1 expression is frequently lost in poorly differentiated gastric cell lines and gastric carcinoma tissues. Loss of RCC1 expression is correlated with tumor differentiation and depth of invasion.
stress can disrupt the Ran gradients through RCC1-dependent and RCC1-independent mechanisms
PI3Kbeta regulates the nuclear envelope through upstream regulation of RCC1 and Ran
RCC1 facilitates a tight binding between the encephalomyocarditis virus leader and cellular Ran GTPase.
RCC1 can induce bipolar spindle formation. Remarkably, RCC1 beads oscillate within spindles from pole to pole, a behavior that could be converted to a more typical, stable association by the addition of a kinesin together with RCC1.
discovery of the first alpha-N-methyltransferase, which we named N-terminal RCC1 methyltransferase (NRMT).
The authors find that RCC1 uses a conformationally flexible loop region we have termed the switchback loop in addition to its N-terminal tail to bind to the nucleosome.
RanBP3 associates with the Ran-specific guanine nucleotide exchange factor, regulator of chromosome condensation 1 (RCC1).
These results indicate that the generation of Ran-GTP in the vicinity of chromosomes by RCC1 is important for the fidelity of mitotic spindle assembly in human cells.
RCC1 release from chromatin in vitro requires a factor(s) distinct from, or in addition to, Ran
phosphorylation of the NLS of RCC1 is required to prevent the binding of importin alpha and beta to RCC1, thereby allowing RCC1 to couple RanGTP production to chromosome binding
This 30 kb deletion contains the exons coding for the RCC1-like domain of RPGR. It is the first report of a macrodeletion that spans the entire RCC1-like domain of RPGR in X-linked retinitis pigmentosa patients
HSV-1 replication is blocked in cell line tsBN2 encoding a temperature sensitive RCC1 protein.
Propose bimodal attachment mechanism for RCC1 in which the tail promotes stable RCC1 association with chromatin through DNA binding in an alpha-N-methylation-dependent manner.
These results show that human RCC1 isoforms have distinct chromatin binding properties, different molecular interactions, and are selectively regulated by phosphorylation, as determined by their different NTRs.
chromosome 1p36 was established to have linkage for adhd.
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly.
chromosome condensation 1
, regulator of chromosome condensation
, regulator of chromosome condensation 1
, RCC1 protein
, in excess
, possible fragment of potential guanine nucleotide exchange factor
, SNHG3-RCC1 readthrough transcript
, cell cycle regulatory protein
, guanine nucleotide-releasing protein
, chromosome condensation protein 1