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Human MAZ Protein expressed in Wheat germ - ABIN1310456
Maloney, Stearman, Bull, Calabrese, Tripp-Addison, Wick, Broeckel, Robbins, Wheeler, Cogan, Loyd: Loss-of-function thrombospondin-1 mutations in familial pulmonary hypertension. in American journal of physiology. Lung cellular and molecular physiology 2012
MAZ can promote the invasion and metastasis of hepatocellular carcinoma by inducing epithelial-mesenchymal transition (EMT (zeige ITK Proteine)).
A quantitative association between MAZ-autoantibody optical density on ELISA and the cumulative inflammatory burden of atherosclerosis on (18)F-FDG (zeige SMUG1 Proteine) PET/CT could be shown, suggesting MAZ-Ab as potential biomarker for atherosclerotic disease.
The data indicate that MAZ is essential to bypass MYB (zeige MYB Proteine) promoter repression by RB family members and to induce MYB (zeige MYB Proteine) expression.
MAZ/FOXF2 (zeige FOXF2 Proteine) axis can promote the proliferation of basal like breast cancer cells and suppress disease progression.
Data suggest that long noncoding RNA PlncRNA1 and microRNA miR (zeige MLXIP Proteine)-34c bound together to regulate the expressions of MAZ, ZO-1 (zeige TJP1 Proteine) and occludin (zeige OCLN Proteine).
a transcriptional factor, Myc-associated zinc finger protein (MAZ), plays an important role in ADAM10 (zeige ADAM10 Proteine) transcription in response to CT-1 (zeige CTF1 Proteine) in neural stem/progenitor cells.
Akt (zeige AKT1 Proteine) phosphorylates MAZ at Thr385, and the phosphorylated MAZ is released from the p53 (zeige TP53 Proteine) promoter, leading to transcriptional activation of p53 (zeige TP53 Proteine).
Myc-associated zinc-finger protein (MAZ) was identified as a direct target of miR (zeige MLXIP Proteine)-449a, mediating the tumor-suppressive effects.
Studies show a feed-forward regulatory pathway in breast cancer cells where SAF-1 acts as a transcriptional inducer of Ras which in turn increases DNA-binding and transcriptional activities of SAF-1 which in turn, increases transcription of Ras.
In conclusion, our present study indicated that miR (zeige MLXIP Proteine)-34c regulated the permeability of BTB via MAZ-mediated expression changes of ZO-1 (zeige TJP1 Proteine), occludin (zeige OCLN Proteine), and claudin-5 (zeige CLDN5 Proteine).
myc (zeige MYC Proteine)-associated zinc finger (MAZ) protein was essential for HIF2alpha (zeige EPAS1 Proteine) activation of the Cav1 (zeige CAV1 Proteine) promoter.
HNF4 (zeige HNF4A Proteine)-1 and MAZ-1 regulate the expression of Rho-GDIgamma and contribute to the differentiation of neural stem cells.
These data support a transcription mechanism for murine KRAS that involves MAZ, PARP-1 (zeige PARP1 Proteine) and duplex-quadruplex conformational changes in the promoter G-rich nuclease (zeige DCLRE1C Proteine) hypersensitive element.
SAF-1 induces VEGF (zeige VEGFA Proteine) transcription by directly binding to its promoter; markedly higher levels of SAF-1 interaction with the VEGF (zeige VEGFA Proteine) promoter was detected in the cartilage tissues of arthritic mice as well as human osteoarthritic patients.
These findings are consistent with a previously unrecognized role for MAZ in muscle gene regulation.
May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors.
, myc-associated zinc finger protein
, purine-binding transcription factor
, serum amyloid A activating factor 1
, serum amyloid A activating factor 2
, serum amyloid A-activating factor-1
, transcription factor Zif87
, zinc finger protein 801
, zinc-finger protein, 87 kilodaltons
, serum amyloid A-activating factor SAF-1