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Urinary NGAL is a good predictor of mortality in established pediatric acute kidney injury (AKI) of heterogeneous etiology and outperforms calprotectin (zeige S100A8 Proteine) and KIM-1 (zeige HAVCR1 Proteine). Urinary calprotectin (zeige S100A8 Proteine) and KIM-1 (zeige HAVCR1 Proteine) predict renal replacement therapy requirement in pediatric AKI.
asma (zeige ACTA1 Proteine) NGAL can be more useful than serum procalcitonin, C-reactive protein (zeige CRP Proteine) , and white blood cell levels for identifying acute pyelonephritis in children with febrile urinary tract infections
These findings indicate that circulating levels of lipocalin-2 (LCN-2)in patients after acute pancreatitis may play a role in chronic low grade inflammation associated with abdominal adiposity.
Neutrophil gelatinase-associated lipocalin may play a dual role during tumorigenetic and developmental processes of endometrial carcinoma.
This study shows the find NGAL levels are significantly higher in regions throughout the brain which are commonly affected by AD pathology.
Through transcriptome profiling and combined gain- and loss-of-function studies, the authors identified LCN2 as a major downstream effector of TCF7L1 (zeige TCF3 Proteine) that drives tumor growth.
Lipocalin 2 could facilitate proliferation of castration-resistant prostate cancer cells by activating androgen receptor (zeige AR Proteine) transcriptional activity.
Urinary NGAL measured at ICU admission was significantly associated with long-term renal outcomes after hospital discharge in MAKE-free ICU survivors. Urinary NGAL measurements at ICU might be useful to identify a high risk population of kidney disease progression after intensive care.
Recent evidence supports the existence of transferrin (zeige Tf Proteine)-independent iron transport mechanisms in the tumor microenvironment, which points to local iron transport proteins such as lipocalin-2 and/or low molecular weight iron-trafficking substances such as siderophores. [review]
Urinary NGAL might play role in the pathway of renal tubular damage in patients with autosomal-dominant polycystic kidney disease
the present study used an animal model to identify NGAL as a potential novel biomarker for mechanical-induced lung injury.
Lipocalin-2 from both myeloid cells and the epithelium combats Klebsiella pneumoniae lung infection in mice.
IL-1beta (zeige IL1B Proteine) has a direct effect on NGAL production by tubular epithelial cells.
Knockout of Lcn2 attenuated tumor-associated lymphangiogenesis and breast tumor metastasis
Overexpression of exogenous kidney-specific Ngal reduced cystic progression and prolonged the lifespan in polycystic kidney disease mice, and was associated with reductions in interstitial fibrosis and proliferation, and augmented apoptosis.
Either Lcn2 deficiency or anti-Lcn2 antibody blockade limits abdominal aortic aneurysm expansion in mice by decreasing neutrophil infiltration in the aorta.
Results suggest that blood brain barrier leakage occurs in white matter after subarachnoid hemorrhage (SAH (zeige ACSM3 Proteine)) and that LCN2 contributes to SAH (zeige ACSM3 Proteine)-induced blood brain barrier disruption.
LCN2 overexpression in bones modifies the bone marrow microenvironment via modulation of the expression of key secreted factors and cytokines, which in turn regulate the hematopoietic stem cell niche behavior enhancing both HSC (zeige FUT1 Proteine) homing in young mice and erythrocytes production in older mice.
LCN2 modulated the secretion of proinflammatory cytokines in PSC of the PDAC tumor microenvironment, whereas downregulation of LCN2-specific receptor SLC22A17 (zeige SLC22A17 Proteine) blocked these effects. Our results reveal how LCN2 acts in the tumor microenvironment links obesity, inflammation, and PDAC development.
results identify lipocalin 2 as a bone-derived hormone with metabolic regulatory effects, which suppresses appetite in a MC4R (zeige MC4R Proteine)-dependent manner, and show that the control of appetite is an endocrine function of bone
we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9 (zeige MMP9 Proteine), TIMP1 (zeige TIMP1 Proteine), and NGAL (also MMP2 (zeige MMP2 Proteine) in 220 kDa complex) without proteolytic activity.
porcine p25alpha (zeige Tppp Proteine) is heavily modified with a variety of modifications: phosphorylation, di- and trimethylation, citrullination and a HexNAc group.
mouse homolog plays a role in IL3 withdrawal-induced apoptosis
, lipocalin 2 (oncogene 24p3)
, 25 kDa alpha-2-microglobulin-related subunit of MMP-9
, migration-stimulating factor inhibitor
, neutrophil gelatinase-associated lipocalin
, oncogene 24p3
, siderocalin LCN2
, SV-40-induced 24P3 protein
, secreted inducible protein 24
, alpha-2-microglobulin-related protein
, alpha-2U globulin-related protein