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Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN1305113
Matsushima, Oppenheim: Interleukin 8 and MCAF: novel inflammatory cytokines inducible by IL 1 and TNF. in Cytokine 1991
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Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN624491
Leyh, Seitz, Dürselen, Schaumburger, Ignatius, Grifka, Grässel: Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes. in Arthritis research & therapy 2015
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Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN413549
Reeves, Williamson, ONeill, Greally, McElvaney: Nebulized hypertonic saline decreases IL-8 in sputum of patients with cystic fibrosis. in American journal of respiratory and critical care medicine 2011
CXCR2 was a direct target of microRNA (miR)-4437, a negative regulator of CXCR2, which was downregulated in peripheral leucocytes from patients with ischemic stroke.
Hepatitis C virus infection is associated with the development of erosive oral lichen planus. The A-allele of IL-8 rs4073 A > T may have a role in the development and progression of oral lichen planus.
Results suggest that Tip110 downregulation in melanoma cells leads to enhanced cell invasion, likely through induction of IL-8 production and release as a growing number of studies have shown that IL-8 is associated with tumor cells migration and invasion. Also, Tip110 regulated IL-8 mRNA stability.
Concentrations of IL-6 and IL-8 were elevated when human gingival keratinocytes cells were infected with Prevotella intermedia and P. nigrescens, but decreased with P. pallens.
The IL-8-251A/T single-nucleotide polymorphism may increase the risk of Coronary Artery disease , especially in people of East Asian ethnicity.
associations of IL-8-251A/T (rs4073) and IL-10 -592C/A (rs1800872) with CAD in the North Indian population
In healthy controls and normoalbuminuria, IL8 serum levels were increased compared to patients with diabetic nephropathy.
GRO-alpha from OSF-associated fibroblasts paracrinally promotes oral malignant transformation and significantly contributes to OSCC development.
The IL8 rs2227306 alleles were distributed equally between prostate cancer, benign prostate hyperplasia and control groups.The IL8 rs1126647 was associated with prostate cancer risk.
This study, for the first time, provided in-depth insights on the effects of amino acid substitutions on IL-8 protein structure, function and disease association.
We also showed that IL-8 stimulation of colon and lung cancer cells-induced glucose uptake and expressions of glucose transporter 3 (GLUT3) and glucosamine fructose-6-phosphate aminotransferase (GFAT), a regulator of glucose flux to the hexosamine biosynthetic pathway, resulting in enhancement of protein O-GlcNAcylation
Interleukin (IL)-8 levels were significantly higher in X-Linked chronic granulomatous disease in the UKcarriers (median 122u/ml) than in healthy controls
Results show that cell-free DNA (cfDNA) could promote colorectal cancer cell proliferation via Toll-like receptor 9 (TLR9) and induced robust release of chemokine interleukin 8 (IL-8; CXCL8 Chemokine).
The IL8 haplotypes showed to be functional both in monocyte-derived macrophages and lymphocytes.
Data showed that human stellate cells (HSC) and their derived IL-8 could induce breast cancer growth and proliferation. As this factor is expressed upon stressors activating the HSCs, this could link systemic inflammation to breast cancer emergence and outgrowth. IL-8 significantly reduced serum-starvation growth arrest on MDA-MB231 cells in vitro and increased cancer proliferation ex vivo.
increased circulating levels of IL-8 were associated with DM of both types in the presence of periodontal disease, which suggests their important role in the pathogenesis of T1DM, T2DM, and CP.
Histone deacetylase 6 regulated expression of IL-8 is involved in the doxorubicin (Dox) resistance of osteosarcoma cells via modulating ABCB1 transcription
Expression and secretion of IL-8 in oral CSCs were both reduced following overexpression of let-7c.
PANDA repressed transcriptional activity of senescence associated inflammatory factor IL8, which leaded to inhibition of cellular senescence.
Both GRO-alpha and IL-8 can activate TAK1/NFkappaB signaling via the CXCR2 receptor.
Molecular characterization of the bovine IER3 gene: Down-regulation of IL-8 by blocking NF-kappaB activity mediated by IER3 overexpression in MDBK cells infected with bovine viral diarrhea virus-1.
STA3 facilitates TLR4-dependent IL-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.
As a pilot study, the present results revealed that identified SNPs in IL8 and TLR4 genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 gene may be a potential candidate for such disease.
Blood levels of cortisol, immunoglobulin G, and IL-8 in relationship to genetics and the incidence of bovine respiratory complex disease are reported.
Genetic variation at the IL8 locus explains a proportion of the inter-breed and inter-individual variation in immunity between neonatal calves which is likely to influence their resistance to infection.
In response to C. abortus infection, both ovine and bovine turbinate cells produce CXCL8 mRNA and protein late in the bacterial developmental cycle.
Studied association of IL8 -105G/A with mastitis somatic cell score in Chinese Holstein dairy cows. Results suggest genotype GG may be a useful genetic marker for mastitis resistance selection and breeding in Chinese Holstein dairy cows.
Data implicate a complex cascade of events during luteolysis, involving Il8 signaling, neutrophil recruitment, and immune cell action within the corpus luteum.
Cadmium exposure induced pulmonary inflammation and increased lung interleukin 8 secretion.
Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected.
study demonstrates that a small experimental rodent model can be utilized for non-invasively monitoring, through a reporter gene system, the activation of an IL-8 promoter region derived from a larger size animal (bovine)
Finding of genetic variation in the IL8 promoter that differentially regulates its expression has significant functional implications for IL8 expression in vitro and which may impact on susceptibility to infectious disease and inflammation.
Polymorphonuclear neutrophils migrate into the early corpus luteum(CL) partially due to its major chemoattractant IL-8 produced at high levels in the CL.
IL8 genotype significantly correlated with mastitis resistance and the locus could be a useful genetic marker for mastitis resistance selection and breeding in Chinese Holstein.
IL8 promoter serial deletion analysis revealed a specific region responsive to ORF50/Rta; may represent an endometrial defense mechanism against viral infection
IL8 gene genetic diversity has a great genetic effect on milk traits and mastitis resistance
The role of NF-kappaB and C/EBP factors in regulating basal and pathogen-induced expression of both genes from cattle, is investigated.
Data describe the expression of IL-8, IL-1beta and their respective receptors, CXCR1 and IL-1R1 in bovine theca cells, and suggest that VEGF is associated with the IL system in theca cells in ovary.
Levels in milk are altered in the presence of bacteria
C-terminal of both bovine IL-8R showed 100% identity, whereas they differ in most other species, suggesting that the two bovine IL-8R initiate similar signal transduction.
This study evaluated the subcellular localization and other functions of TGEV nsp7 protein through analysis of its effects on cell growth, cell cycle progression, interleukin 8 (IL-8) expression, and NF-kappaB activation.
The JNK-activated AP-1 subunit c-Jun was critical for the up-regulation of IL-8 expression by PRRSV
These results suggest that porcine circovirus 2 induces IL-8 secretion via the TLR2/MyD88/NF-kappaB signalling pathway.
Facilitated degradation of the RGS16 by porcine circovirus type 2 ORF3 further enhances NFkappaB translocation into the nucleus through the ERK1/2 signalling pathway and increased IL-6 and IL-8 mRNA transcripts.
Suggest that the interplay between TGFbeta-2 and LPS regulates the levels of IL-8 in the immature newborn intestine.
downregulated gene expression elite controllers (fraction of human population displaying resistance to HIV infection)
Data suggest that MSK1 and MSK2 are the major CREB kinases in fibroblast-like synoviocytes from rheumatoid arthritis patients stimulated with lysophosphatidic acid and that phosphorylation of CREB1 at Ser-133 plays a significant role in IL-8 production.
Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta, IL-8 and TNF-alpha in porcine alveolar macrophages.
local expression of IL-1beta and IL-8 in non-bacterial thrombotic endocarditis, Staphylococcus aureus infective endocarditis, animals with S. aureus sepsis without endocarditis and controls
In swine, IL-8, TNF-ALPHA, INOS AND MIP-1BETA were increased during mechanical ventilation in a time-related fashion.
Classical swine fever virus NS2 protein promotes interleukin-8 expression.
Developmental changes in IL-8 isoforms may serve to minimize its inflammatory effects in the fetus and also provide a mechanism to restore its full activity after birth
Stress decreased IL-8 gene expression in both CeA lesioned and non-lesioned animals. But, CeA lesions increased the tissue expression of IL-8 mRNA prior to and after stress exposure.
gene expression and epistasis analysis indicated that CXCL8(IL-8) was a functional target of vitamin D3-mediated HSPC regulation. Together, these findings highlight the relevance of developmental 1,25(OH)D3 availability for definitive hematopoiesis and suggest potential therapeutic utility in HSPC expansion
Targeted expression of the human oncogene KRASG12V in zebrafish gills induces inflammation and cxcl8-l1 expression.
Data show that both Cxcl8-l1 and Cxcl8-l2 are required for larva survival upon Salmonella Typhimurium infection.
results explain how early H2O2 signal regulates neutrophil recruitment at all phases, directly via Lyn oxidation or indirectly by modulating cxcl8 gene expression
Zebrafish Cxcl8s play a role in neutrophil recruitment under acute inflammatory conditions.
The data identify HOXC9 as an endothelial cell active transcriptional repressor promoting the resting, antiangiogenic endothelial cell phenotype in an interleukin 8-dependent manner
Here, we report the characterisation of genes encoding the zebrafish Cxcl8, Cxcr1 and Cxcr2
At the 2-wk time point, interleukin 8 gene expression was comparable in intervertebral discs injected with chondrocytes in controls, whereas its expression in IVDs injected with saline increased 50-fold
Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) decreased significantly in Dachengqi decoction treatment group.
The JNK pathway plays an important role in mechanical ventilation-stimulated TNF-alpha expression in alveolar macrophages, but the injury-stimulated IL-8 expression may be regulated by other signaling pathways.
IL-8 and IL-1ra showed correlation with the severity of colitis. These observations should significantly further understandings on the role of neutrophils and monocytes in the immunopathogenesis of ulcerative colitis
Results suggested that chemokine expression by cultured equine BECs following exposure to pulmonary hemorrhage conditions may contribute to the development of inflammatory airway disease in horses.
Mapped six genes (EIF4G3, HSP90, RBBP6, IL8, TERT, and TERC) on the chromosomes of Equus caballus, Equus asinus, Equus grevyi, and Equus burchelli by fluorescence in situ hybridization.
This study examined effects of in vitro exposure to solutions of hay dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.
These results suggest that MMP-1 and IL-8 are both involved in the exercise-induced stress response, and this represents a starting point from which to understand the adaptive responses to this phenomenon.
The acute pulmonary neutrophilia characteristic of recurrent airway obstruction was not associated with an increase in expression of chemokines in pulmonary mononuclear cells from disease-susceptible horses.
Duck IL-8 is good immunostimulant to enhance the immune efficiency of avian influenza vaccine in ducks.
IL-8 homologue has been cloned and identified; the chemokine CXC domain, which contained Glu-Leu-Arg motif and four cysteine residues, was well conserved
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.
T-cell chemotactic factor
, alveolar macrophage chemotactic factor I
, beta endothelial cell-derived neutrophil activating peptide
, beta-thromboglobulin-like protein
, chemokine (C-X-C motif) ligand 8
, granulocyte chemotactic protein 1
, lung giant cell carcinoma-derived chemotactic protein
, lymphocyte derived neutrophil activating peptide
, monocyte-derived neutrophil chemotactic factor
, monocyte-derived neutrophil-activating peptide
, neutrophil-activating peptide 1
, small inducible cytokine subfamily B, member 8
, tumor necrosis factor-induced gene 1
, C-X-C motif chemokine 8
, neutrophil activating peptide 1
, alveolar macrophage-derived chemotactic factor-I
, interleukin 8
, neutrophil attractant/activation protein 1
, neutrophil attractant/activation protein-1
, permeability factor 1
, Interleukin-8-like protein
, Neutrophil attractant protein 1
, neutrophil attractant protein-1
, uncharacterized protein LOC100036815