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Secretome analysis revealed that Oct4 (zeige POU5F1 Proteine) upregulated interleukin 24 (IL24) expression through STAT3 (zeige STAT3 Proteine) and NFkappaB (zeige NFKB1 Proteine) signaling, and siRNA against IL24 increased IRinduced senescence, whereas recombinant human IL24 suppressed it. The results of the present study indicated that Oct4 (zeige POU5F1 Proteine) confers IR resistance on breast cancer cells by suppressing IRinduced premature senescence through STAT3 (zeige STAT3 Proteine)- and NFkappaB (zeige NFKB1 Proteine)-mediated IL24 production.
These results suggest that hIL-24 can reverse the cisplatin (DDP (zeige TIMM8A Proteine))- resistance of lung cancer cells, and that the associated mechanism involves the induction of apoptosis and G2/M-phase arrest through the phosphoinositide3-kinase (PI3K (zeige PIK3CA Proteine))/AKT (zeige AKT1 Proteine) signaling pathway, as well as a decrease in drug resistance through P-gp (zeige ABCB4 Proteine) expression
These results indicated that Mda7/IL24 could induce terminal differentiation of B lymphoma cells by regulating the expression of Blimp1 (zeige PRDM1 Proteine) and Bcl6 (zeige BCL6 Proteine) via altering the P38 MAPK (zeige MAPK14 Proteine) signaling pathway.
These results demonstrate a previously unrecognized role of IL24 in inhibition of translation, mediated through both phosphorylation of eIF2alpha (zeige EIF2A Proteine) and dephosphorylation of 4E-BP1 (zeige EIF4EBP1 Proteine), and provide the first direct evidence for translation control of gene-specific expression by IL24
IL-24 inhibits AKT (zeige AKT1 Proteine) via regulating the HMGA1 (zeige HMGA1 Proteine)/miR (zeige MLXIP Proteine)-222 signaling node in human lung cancer cells and acts as an effective tumor suppressor.
this paper shows that IL-24 represents a potential biomarker of allergic inflammation and a Th2 polarized condition of the epithelium
Low IL24 expression is associated with endometriosis.
IL-20 (zeige IL20 Proteine) and IL-24 increased the production of monocyte chemoattractant protein-1 (zeige CCL2 Proteine) by activated spondyloarthritis synovial fluid monocytes, decreased the production of Dickkopf-1 (zeige DKK1 Proteine) by SpA (zeige FASL Proteine) fibroblast-like synovial cells and induced mineralization in human osteoblasts; taken together, findings indicate disease-aggravating functions of IL-20 (zeige IL20 Proteine) and IL-24 in spondyloarthritis
a novel pathway for mda-7/IL-24-induced caspase (zeige CASP3 Proteine)-independent apoptosis in neuroblastoma (zeige ARHGEF16 Proteine) cells mediated through modulation of AIF (zeige AIFM1 Proteine), ATM (zeige ATM Proteine), and gamma-H2AX (zeige H2AFX Proteine).
mda-7/IL-24 directly regulates miRNA expression in cancer cells and highlights the novelty of the mda-7/IL-24-miR (zeige MLXIP Proteine)-221-beclin-1 (zeige BECN1 Proteine) loop in mediating cancer cell-specific death.
our data suggest that IL-20 (zeige IL20 Proteine) subfamily cytokines, particularly IL-20 (zeige IL20 Proteine), IL-22 (zeige IL22 Proteine), and IL-24, might provide therapeutic benefit for patients with Diabetic foot ulcers (DFU) .
this study shows that IL-24 promotes Pseudomonas aeruginosa keratitis through the suppression of early protective mucosal immunity
Loss of IL-24 expression is associated with breast cancer.
A psoriasis-like skin inflammation in mice with epidermis-specific inhibition of NF-kappaB (zeige NFKB1 Proteine) was triggered by TNFR1 (zeige TNFRSF1A Proteine)-dependent upregulation of interleukin-24 & activation of STAT3 (zeige STAT3 Proteine) signaling in keratinocytes.
IL-24 suppresses the growth of normal vascular smooth muscle cells by inhibiting hydrogen peroxide-induced reactive oxygen species (ROS (zeige ROS1 Proteine)) production through the regulation of mitochondrial ROS (zeige ROS1 Proteine) production and expression of antioxidant enzymes
Secretory mIL-24 did not induce the expression of the IL-6 (zeige IL6 Proteine), TNF-alpha (zeige TNF Proteine) or IFN-gamma (zeige IFNG Proteine) gene in spleen cells
T cell receptor stimulation induces IL-24 expression in T helper type (Th)2 cells by the coordinate action of Stat6 (zeige STAT6 Proteine) and c-Jun (zeige JUN Proteine) transcription factors at the transcriptional level.
induction of Il24 by oncogenes may support tumor growth at the early stages of cancer
Grp170 (zeige HYOU1 Proteine) enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
IL-4-induced secreted protein
, melanocyte-associated Mda-7
, melanoma differentiation-associated gene 7 protein
, suppression of tumorigenicity 16 (melanoma differentiation)
, th2-specific cytokine FISP
, cytokine-like protein Mob-5
, interleukin 24