IL-24 Protein (AA 53-207) (Fc Tag)

Produktnummer ABIN6253245

Dieses Recombinant IL-24-Protein wird in CHO Cells produziert.

Kurzübersicht für IL-24 Protein (AA 53-207) (Fc Tag) (ABIN6253245)

Target: IL-24 (IL24) (Interleukin 24 (IL24))

Protein-Typ: Recombinant

Spezies: Human

Quelle: CHO Cells

Reinheit: >98 % (SDS-PAGE)

Produktdetails

Proteineigenschaft: AA 53-207

Aufreinigungstag / Konjugat: Dieses IL-24 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: IL-24 (human):Fc (human) (rec.)

Spezifität: The extracellular domain of human IL-24 (aa 53-207) is fused to the N-terminus of the Fc region of a human IgG1.

Produktmerkmale: Protein. The extracellular domain of human IL-24 (aa 53-207) is fused to the N-terminus of the Fc region of a human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). IL-24 is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control cell survival and proliferation by inducing rapid activation of particular transcription factors called STAT1 and STAT3. It is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, psoriasis and cancer. IL-24 has antiproliferative properties is inhibiting angiogenesis and may contribute to terminal cell differentiation.

Endotoxin-Niveau: <0.06EU/μg protein (LAL test, Lonza).

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Handhabung: Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Antigendetails

Target: IL-24 (IL24) (Interleukin 24 (IL24))

Andere Bezeichnung: IL-24

Hintergrund:

Alternate Names/Synonyms: Interleukin-24, MDA7, ST16

Product Description: IL-24 is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control cell survival and proliferation by inducing rapid activation of particular transcription factors called STAT1 and STAT3. It is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, psoriasis and cancer. IL-24 has antiproliferative properties is inhibiting angiogenesis and may contribute to terminal cell differentiation.

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Autophagie