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levels of the shed, soluble form of VCAM1 are prominently increased in the plasma of aged individuals
The results suggest that cytokine-induced autophagy contributes to late-phase IkappaBalpha degradation, facilitates NF-kappaB nuclear translocation and VCAM-1 transcription for long-term VCAM-1 expression.
Data provide evidence that VCAM-1 appears to be overexpressed in prostate cancer (PCa) and might influence distant metastasis. Also, VCAM-1 facilitates PCa cells adhesion to osteoblasts.
Levels of soluble VCAM-1 are significantly associated with new-onset atrial fibrillation in the general community.
a significant increase in levels of adhesion molecules (VCAM-1) and selectins (E-selectin) in parallel with increased severity of diabetic retinopathy, with a significant difference of inflammatory markers between stages of retinopathy, is reported.
Disease-modifying treatments are not responsible for the higher VAP-1 levels in patients with cerebral microbleeds (CMBs) in multiple sclerosis; instead, disease-modifying treatments could mask even higher VAP-1 levels in patients with CMBs
Urinary angiostatin, CXC chemokine ligand 4 (CXCL4) and vascular cell adhesion molecule-1 (VCAM-1) were significantly higher in patients with active renal disease than in patients with active non-renal disease.
Increased sEng and sVCAM-1 and decreased free VEGF plasma levels were found in women with severe preeclampsia, compared with normotensive pregnant group.
VCAM-1 displays significantly higher expression on high-risk (symptomatic) vs low-risk (asymptomatic) carotid plaques. Ultrasound contrast agents bearing ligands for VCAM-1 can sustain high-shear attachment and may be useful for identifying patients in whom more aggressive treatment is warranted.
Knockdown of YAP/TAZ using siRNA significantly reduced the expression of the leukocyte adhesion molecule VCAM1 induced by TNF-alpha.
High VCAM1 expression is associated with Cardiovascular Disease.
not a specific screening marker for pulmonary arterial hypertension in systemic sclerosis
We observed an increase of VCAM-1 urine levels in diabetic nephropathy-basal patients compared to diabetic controls and an increase of urinary neprilysin in DN-treated patients with persistent albuminuria
Urinary angiostatin and VCAM-1 are predictive of specific histological changes in concurrent lupus nephritis renal biopsies.
In summary, it could be concluded that the expression of gene VCAM-1 was down regulated by taurocholic acid through miR-590-3p and that gene VCAM-1 could participate in the regulation of cell growth, cell proliferation and cell apoptosis
VCAM-1 expression is upregulated by CD34+/CD133+-stem cells derived from septic patients
Circulating soluble vascular cell adhesion molecule (VCAM-1) level was a useful diagnostic parameter for understanding the difference between coronary artery disease (CAD) and cardiac syndrome X (CSX).
findings indicate a novel role for JAK2-V617F in activation of beta1 integrins and enhanced adhesion of granulocytes and 32D myeloid progenitors to VCAM1-coated surfaces
High VCAM1 expression is associated with Cardiovascular Disease Risk.
VCAM-1 levels are elevated in serum of cystic fibrosis patients.
Brain endothelial cells in the aged hippocampus express an inflammatory transcriptional profile with focal upregulation of vascular cell adhesion molecule 1 (VCAM1), a protein that facilitates vascular-immune cell interactions.
These studies showed that VCAM1 contributes not only to the initiation of myelination but also to its regulation through controlling the abundance of CD69, demonstrating that an intercellular molecule whose primary role is in the immune system can also play an unexpected role in the CNS.
Results showed that MOVACs transfected with pCMV5-HA-RKIP significantly inhibited TNF-a induced mRNA and protein expression of ICAM-1 and VCAM-1.
VCAM-1 promotes CD34(+)VLA-4(+) cell mobilization into the damaged myocardial tissues.
These studies define differential roles for VCAM-1 in SC depending on the state of their niche.
sVCAM-1 is a novel chemoattractant for neutrophils and an activator for alveolar macrophages
VCAM1 affects the neural stem cells fate by signaling through its intracellular domain to regulate beta-catenin signaling in a context-dependent manner
Reducing Cadm1 expression in the hypothalamus and hippocampus promoted a negative energy balance and weight loss
Here we delineated an inflammation-driven inhibitory mechanism of beige adipogenesis in obesity that required direct adhesive interactions between macrophages and adipocytes mediated by the integrin alpha4 and its counter-receptor VCAM-1, respectively; expression of the latter was upregulated in obesity.
High VCAM1 expression is associated with Experimental Autoimmune Myocarditis
Aortic VCAM-1 was expressed early and indicated vascular inflammation in collagen-induced arthritis.
this manuscript shows that endothelial cell FAK activity induces VCAM-1 expression and contributes to atherosclerosis
Gas6-FoxO-1 signaling axis plays an important role in VCAM-1 expression in the context of venous thromboembolism by promoting bone marrow mononuclear cell-endothelial cell adhesion.
These results suggest that Tie2 signaling induces alpha4beta1 integrin activation on bone marrow-mast cell progenitor for adhesion to VCAM-1.
Repeated social defeat-induced VCAM-1 protein expression were localized to the vasculature of brain regions implicated in fear and anxiety responses.
neutrophils are reliant on endothelial activation for adhesion, initially via E-selectin and subsequently, by integrin-mediated binding to ICAM-1 and VCAM-1, combined with CXCL8-dependent chemotaxis.
PDE4 inhibition reduces neointima formation and inhibits VCAM-1 expression and histone methylation in an Epac-dependent manner.
Activation of Wnt/beta-catenin signaling in AECs attenuated intercellular adhesion molecule 1 (ICAM-1)/vascular cell adhesion molecule 1 (VCAM-1)-mediated adhesion of both macrophages and neutrophils to AECs.
a new mechanism by which PKC-beta activation promotes EC dysfunction caused by the de-regulation of the IL-18/IL-18BP pathway, leading to increased VCAM-1 expression, monocyte/macrophage adhesion, and accelerated atherosclerotic plaque formation in diabetes
Succinobucol loaded nanoparticles suppress lung metastasis of breast cancer by inhibition of VCAM-1 expression
study provides insights into the mechanism of haematopoietic stem and progenitor cells (HSPC) homing and reveals the essential role of a VCAM-1(+) macrophage population with patrolling behaviour in HSPC retention
Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule-1 mRNA.
the p38-MAPK/CREB pathway plays a critical role in TNFalpha-induced VCAM-1 expression
Data show that all five molecules, BNP, ICAM-1, TNF-alpha, VCAM-1 and IL-6, quickly and reliably signaled adverse interactions.
A suggestive association was found between C558T genotype and the time the newborn piglet needs to reach the udder as well as a significant one with the time to make the first ingestion of colostrum.
Altered shear stress stimulates upregulation of endothelial VCAM-1 and ICAM-1 in a BMP-4- and TGF-beta1-dependent pathway.
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene.
, vascular cell adhesion protein 1
, V-CAM 1
, vascular cell adhesion molecule-1
, vascular cell adhesion molecule 1
, vascular cell adhesion protein 1-like