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Human AGER Protein expressed in HEK-293 Cells - ABIN2180572
Xue, Rai, Singer, Chabierski, Xie, Reverdatto, Burz, Schmidt, Hoffmann, Shekhtman: Advanced glycation end product recognition by the receptor for AGEs. in Structure (London, England : 1993) 2011
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Human AGER Protein expressed in Human Cells - ABIN2004453
Sugaya, Fukagawa, Matsumoto, Mita, Takahashi, Ando, Inoko, Ikemura et al.: Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart ... in Genomics 1995
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a significant association between RAGE gene rs1800624 and rs1800625 polymorphisms and Age-related macular degeneration risk, is reported.
HMGB1 (zeige HMGB1 Proteine) mediates fibroblast activity via RAGE-MAPK (zeige MAPK1 Proteine) and NF-kappaB (zeige NFKB1 Proteine) signaling in keloid scar formation.
Data revealed that hESC accumulates CML (zeige BCR Proteine) and RAGE under oxidative stress conditions in different ways than somatic cells, being the accumulation of CML (zeige BCR Proteine) statistically significant only in somatic cells and, conversely, the RAGE increase exclusively appreciated in hESC.
In women with Polycystic ovary syndrome(PCOS), the low ovarian levels of the anti-inflammatory sRAGE suggest that sRAGE could represent a biomarker and a potential therapeutic target for ovarian dysfunction in PCOS. Whether there is a direct causal relationship between sRAGE and vit (zeige VIT Proteine) D in the ovaries remains to be determined
current research highlighted the Glo-I/AGE/RAGE system as an interesting therapeutic target in chronic liver diseases. These findings need further elucidation in preclinical and clinical studies.
Our findings suggested that polymorphisms in the RAGE gene are involved in genetic susceptibility to Alzheimer disease but did not modify the risk of lewy body disease.
Findings suggest soluble Receptor (zeige IFNAR1 Proteine) for Advanced Glycation End products (sRAGE) protein from sRAGE-mesenchymal stem cells (MSC (zeige MSC Proteine)) has better protection against neuronal cell death than sRAGE protein or single MSC (zeige MSC Proteine) treatment by inhibiting the RAGE cell death cascade and RAGE-induce inflammation.
Protection against diabetic nephropathy in RAGE knockout mice is likely to be due in part to the decreased responsiveness to TGF beta (zeige TGFB1 Proteine) stimulation and an antiapoptotic phenotype in mesangial cells.
the A allele of RAGE -374T/A polymorphism probably increase diabetic retinopathy risk (Meta-Analysis)
Advanced glycation end products decrease collagen I levels in fibroblasts from the vaginal wall of patients with pelvic organ prolapse via the RAGE, MAPK (zeige MAPK1 Proteine) and NF-kappaB (zeige NFKB1 Proteine) pathways.
Chronic unpredictable stress (CUS) promotes significant morphological changes and causes robust upregulation of HMGB1 (zeige HMGB1 Proteine) messenger RNA in enriched hippocampal microglia and robust and persistent upregulation of RAGE messenger RNA. CUS increased surface expression of RAGE protein on hippocampal microglia and anhedonic behavior. RAGE knockout mice were resilient to stress-induced anhedonia.
study found that diabetes predisposes to more severe infections because of additional inflammatory output through dual activation of MyD88 (zeige MYD88 Proteine) by not only TLR4 (zeige TLR4 Proteine) but also RAGE
RAGE controls myocardial dysfunction and oxidative stress in high-fat fed mice by sustaining mitochondrial dynamics and autophagy-lysosome pathway.
these data provide a previously uncharacterized in vivo mechanism contingent on oligodeoxy-nucleotide -administered dose, where TLR9 (zeige TLR9 Proteine) governs the primary response and RAGE plays a distinct and cooperative function in providing a pivotal role in balancing the immune response.
data demonstrate that under the diabetic condition, DRG neurons are directly affected by elevated levels of glucose, independent of vascular or glial signals, and dependent on RAGE expression.
findings suggest that HMGB1 (zeige HMGB1 Proteine) induces the transcytosis of albumin (zeige ALB Proteine) via RAGE-dependent Src (zeige SRC Proteine) phosphorylation and Cav-1 (zeige CAV1 Proteine) phosphorylation. These studies revealed a new mechanism of HMGB1 (zeige HMGB1 Proteine)-induced endothelial hyperpermeability.
data suggest that S100A8 (zeige S100A8 Proteine)/A9 acts directly on BV-2 microglial cells via binding to TLR4 (zeige TLR4 Proteine) and RAGE on the membrane and then stimulates the secretion of proinflammatory cytokines through ERK (zeige EPHB2 Proteine) and JNK (zeige MAPK8 Proteine)-mediated NF-kappaB (zeige NFKB1 Proteine) activity in BV-2 microglial cells.
Activation of RAGE facilitates the development of hypoxia-induced pulmonary hypertension by increasing ECM (zeige MMRN1 Proteine) deposition in pulmonary arteries.
knockout of RAGE significantly ameliorates mainstream cigarette smoke-induced airway inflammation in mice
Here, the authors show that RAGE deficiency impairs anti-viral immunity during an early-life infection with pneumonia virus of mice (PVM; a murine analogue of RSV). The elevated viral load was associated with the release of high mobility group box-1 (HMGB1 (zeige HMGB1 Proteine)) which triggered airway smooth muscle remodelling in early-life.
Our results suggested that the increased RAGE expression in inflammatory circumstances and interaction with AGEs are risk factors in decreasing of aggrecan (zeige ACAN Proteine) content in nucleus pulposus.
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847).
RAGE isoform NtRAGE-delta
, RAGE isoform sRAGE-delta
, advanced glycation end-products receptor
, receptor for advanced glycosylation end products
, advanced glycosylation end product-specific receptor variant 2
, advanced glycosylation end product-specific receptor variant 3
, advanced glycosylation end product-specific receptor variant 4
, advanced glycosylation end product-specific receptor variant 5
, advanced glycosylation end product-specific receptor variant 1
, advanced glycosylation end product-specific receptor variant 6
, advanced glycosylation end product-specific receptor variant 7
, advanced glycosylation end product-specific receptor variant 8
, advanced glycation end product receptor
, advanced glycosylation end product-specific receptor
, MAPK/MAK/MRK overlapping kinase
, renal tumor antigen