RAGE Protein (AA 1-341) (His tag)
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- Target Alle RAGE (AGER) Proteine anzeigen
- RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 1-341
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Spezies
- Ratte
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses RAGE Protein ist gelabelt mit His tag.
- Sequenz
- Met1-Leu341
- Produktmerkmale
- A DNA sequence encoding theRat Ager protein (Q63495) (Met1-Leu341) was expressed with a C-His.
- Reinheit
- >90 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product AGER Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4.
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Haltbarkeit
- 12 months
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- Target
- RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
- Andere Bezeichnung
- Ager (AGER Produkte)
- Synonyme
- RAGE Protein, AGER Protein, advanced glycosylation end-product specific receptor Protein, advanced glycosylation end product-specific receptor Protein, MAPK/MAK/MRK overlapping kinase Protein, AGER Protein, Ager Protein, LOC719012 Protein
- Hintergrund
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Background: Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certain members of the S100/calgranulin family of proteins, high mobility group box 1 (HMGB1), advanced oxidation protein products, and amyloid (beta-sheet fibrils). Initial studies investigating the role of RAGE in renal dysfunction focused on diabetes, neurodegenerative disorders, and inflammatory responses. However, RAGE also has roles in the pathogenesis of renal disorders that are not associated with diabetes, such as obesity-related glomerulopathy, doxorubicin-induced nephropathy, hypertensive nephropathy, lupus nephritis, renal amyloidosis, and ischemic renal injuries. RAGE represents an important factor in innate immunity against pathogens, but it also interacts with endogenous ligands, resulting in chronic inflammation. RAGE signaling has been implicated in multiple human illnesses, including atherosclerosis, arthritis, Alzheimer's disease, atherosclerosis and aging associated diseases.
Synonym: Receptor for advanced glycosylation end products,RAGE
- Molekulargewicht
- 36.1 kDa
- UniProt
- Q63495
- Pathways
- Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteine
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