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prostacyclin regulates bone growth via the Epac/Rap1 pathway
cAMP binds Xepac protein enabling it to activate the Ca2+ pathway, which is necessary to start and maintain X. laevis vitellogenin uptake.
This study indicates a novel role for Epac1 in PGE2-induced epithelial-to-mesenchymal transition and subsequent activation of beta-catenin (zeige CTNNB1 Proteine)
EPAC1 and EPAC2 (zeige RAPGEF4 Proteine) expression levels were significantly lower in bladder cancer tissue than in normal bladder tissue. In addition, bladder cancer cell lines showed reduced EPAC1 mRNA expression. Furthermore, EPAC1 overexpression in bladder cancer cell lines induced morphologic changes and markedly suppressed cell migration without affecting cell viability.
study suggests for the first time the mechanistic insights of mode of action of a primary cAMP-dependent sensor, Exchange protein activated by cAMP 1 (EPAC1), via its interaction with A-kinase anchoring protein 9 (AKAP9).
We show that hematopoietic cell generation requires cAMP signaling through the Exchange proteins activated by cAMP (cAMP-Epac) axis..in hematopoietic progenitor and stem-like cells, cAMP induction mitigated oxidative stress, created a redox-state balance, and enhanced C-X-C chemokine receptor type 4 (CXCR4 (zeige CXCR4 Proteine)) expression, benefiting the maintenance of these primitive cells
No significant association was observed between RAPGEF3 SNPs and the risk of Alzheimer's disease or neuropsychiatric inventory scores.
This review focus is on the function of Epac in the heart. Accumulating evidence has revealed that both Epac1 and Epac2 (zeige RAPGEF4 Proteine) play important roles in the structure and function of the heart under physiological and pathological conditions. [review]
This interaction is promoted by EPAC1 activation, triggering its translocation to the plasma membrane and binding to NHERF1 (zeige SLC9A3R1 Proteine). Our findings identify a new CFTR (zeige CFTR Proteine)-interacting protein and demonstrate that cAMP activates CFTR (zeige CFTR Proteine) through two different but complementary pathways - the well-known PKA-dependent channel gating pathway and a new mechanism regulating endocytosis that involves EPAC1.
The contribution of EGFR (zeige EGFR Proteine), EPAC, and Ca(2 (zeige CA2 Proteine)+) in CDCA-induced activation of CFTR (zeige CFTR Proteine)-dependent Cl(-) secretion.
Microtubule stabilization was further suggested by the finding that ascorbate increased the amount of Epac1 bound to alpha-tubulin (zeige TUBA4A Proteine).
during Epac1-induced activation of mTORC1 and mTORC2 (zeige CRTC2 Proteine), Epac1 may have an additional function as a scaffold protein (zeige HOMER1 Proteine)
These data indicate that Epac1 may be protective to the retina through inhibition of key inflammatory mediators.
Arrhythmic effects of Epac-mediated ryanodine receptor (zeige RYR3 Proteine) activation in Langendorff-perfused murine hearts
In retinopathy, EPAC-1 expression is decreased in a microRNA-7-mediated manner, contributing to endothelial dysfunction.
Epac1 exerts a tonic inhibition of in vivo basal microvascular permeability
In behavioral tests, Epac1-/- mice exhibited similar phenotype to those of WT mice.
2-arachidonoylglycerol (2-AG) is an endogenous cannabinoid that depresses synaptic transmission through stimulation of CB1 (zeige CNR1 Proteine) receptors. Among the six isoforms of phospholipase C (PLC (zeige PLC Proteine); PLCbeta, PLCgamma, PLCdelta, PLCepsilon (zeige PLCE1 Proteine), PLCzeta (zeige PLCz1 Proteine), PLCeta), only PLCbeta has been linked to 2-AG synthesis. Here we demonstrate that 8-CPT (zeige DHDDS Proteine)-2Me-cAMP, a selective agonist of the cAMP sensor protein Epac, enhances 2-AG-mediated synaptic depress...
Data suggest that Epac1 reduces formation of the NLRP3 (zeige NLRP3 Proteine) inflammasome to reduce inflammatory responses in the retinal vasculature.
Results demonstrate that Epac1 plays an important role in regulating energy balance and glucose homeostasis by promoting leptin (zeige LEP Proteine) expression and secretion in white adipose tissue.
data demonstrate that endogenous PGE2, EP2 (zeige SPAG11A Proteine) receptors, and EPAC are prerequisites for maximal LPS (zeige TLR4 Proteine)-induced IL-33 (zeige IL33 Proteine) expression and that exogenous PGE2 can amplify IL-33 (zeige IL33 Proteine) production via EP2 (zeige SPAG11A Proteine) and EP4 (zeige PTGER4 Proteine) receptors.
Epac1 is involved in AC5 (zeige ADCY5 Proteine)-mediated catecholamine stress-induced cardiac fibrosis. Epac1 is involved in AC5 (zeige ADCY5 Proteine)-mediated elongation of atrial fibrillation.
binds cAMP and activates the Ras superfamily guanine nucleotide binding protein (Rap1A)in a PKA-independent manner
Rap guanine nucleotide exchange factor (GEF) 3
, RAP guanine-nucleotide-exchange factor 3
, exchange protein directly activated by cAMP 1
, rap guanine nucleotide exchange factor 3
, Rap1 guanine-nucleotide exchange factor
, rap guanine nucleotide exchange factor 3-like
, EPAC 1
, Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
, cAMP-regulated guanine nucleotide exchange factor I
, exchange factor directly activated by cAMP 1
, cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI)
, epac 1