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Human LRG1 Protein expressed in Wheat germ - ABIN1309718
Boström, Wu, Jedrychowski, Korde, Ye, Lo, Rasbach, Boström, Choi, Long, Kajimura, Zingaretti, Vind, Tu, Cinti, Højlund, Gygi, Spiegelman: A PGC1-?-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. in Nature 2012
LRG-1 was highly expressed in human retinoblastoma sections, thus providing new insights into the molecular mechanism of retinoblastoma pathogenesis, and suggests a possible new therapeutic target.
The detection of LRG1 in accordance with the DeltaRct value (electron-transfer resistance at the electrode surface) of the sensor layer incorporating LRG1 BP3 peptides showed a statistically significant difference (p < 0.001) between adenomas and carcinomas, indicating that the potential use of this biosensing platform for detecting the CRC biomarker, as well as for monitoring the colorectal adenoma-to-carcinoma tra...
This study shows that TNF-alpha (zeige TNF Proteine) is the predominant proinflammatory cytokine that induces the secretion of LRG1. LRG1 contributes to angiogenesis-coupled de novo bone formation by increasing angiogenesis and recruiting MSCs in the subchondral bone of osteoarthritis joints.
the expression of 3 miRs and 9 mRNAs associate with the PIK3CA (zeige PIK3CA Proteine) status. Expression of LRG1 is independent of luminal (A or B) subtype, decreased after neo-adjuvant aromatase (zeige CYP19A1 Proteine) inhibitor treatment.
Plasma LRG1 predicts both albuminuria and Chronic kidney disease progression beyond traditional risk factors. It may play a role in the pathologic pathway leading to progression of diabetic kidney disease in T2 Diabetes mellitus.
LRG1 may be a key regulatory factor of allergic responses.
Results find serum LRG1 levels are significantly associated with LRG1 expression in gastric tumors. Its inhibition suppresses gastric cancer cell growth and invasion suggesting that LRG1 is implicating in gastric tumorigenesis.
LRG1 plays a crucial role in the proliferation and apoptosis of colorectal cancer (CRC (zeige CALR Proteine)) by regulating RUNX1 (zeige RUNX1 Proteine) expression. LRG1 may be a potential detection biomarker as well as a marker for monitoring recurrence and therapeutic target for CRC (zeige CALR Proteine).
These findings suggest that sputum LRG is a promising biomarker of local inflammation in asthma.
combination of modified whole blood LRG1 mRNA levels, plasma LRG1 protein and Alvarado score at the ED may be useful to diagnose simple and complicated acute appendicitis from other causes of abdominal pain
our data suggest that LRG promotes lung fibrosis by modulating TGF-beta (zeige TGFB1 Proteine)-induced Smad2 (zeige SMAD2 Proteine) phosphorylation and activating profibrotic responses in fibroblasts.
Our study indicates that LRG promotes the differentiation and the proliferation of Th17 in vivo and contributes to the development of collagen-induced arthritis
in vitro stimulation of mouse renal cortical tubular epithelial cells with excessive ALB (zeige ALB Proteine) led to LRG mRNA up-regulation and its protein secretion, which was effectively blocked by IL-1 (zeige IL1A Proteine) receptor antagonist. These results suggest that urinary LRG could be applied to a biomarker detecting renal tubular injury in various renal diseases.
Hippocampal LRG overexpression contributes to synaptic dysfunction, which leads to memory impairment with advance of age.
findings reveal a novel and essential role of Lrig1 (zeige Lrig1 Proteine) in regulating morphogenic events that shape the hippocampal circuits and establish that the assembly of TrkB (zeige NTRK2 Proteine) with Lrig1 (zeige Lrig1 Proteine) represents a key mechanism for understanding how specific neuronal populations expand the repertoire of responses to BDNF (zeige BDNF Proteine) during brain development
Loss of LRG is associated with Lewis lung carcinoma.
Human LRG (hLRG) concentration in the cerebrospinal fluid (CSF (zeige CSF2 Proteine)) was measured and hLRG expression in post-mortem human cerebral cortex and mouse LRG (mLRG) in the brain were examined.
Mice lacking Lrg1 develop a mild retinal vascular phenotype but exhibit a significant reduction in pathological ocular angiogenesis.
cDNA clones for murine leucine-rich alpha2-glycoprotein were isolated. Expression of LRG during differentiation of 32Dcl3G cells preceded the expression of lactoferrin (zeige LTF Proteine) and gelatinase but followed myeloperoxidase (zeige MPO Proteine).
The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002
, leucine-rich alpha-2-glycoprotein 1
, leucine-rich alpha-2-glycoprotein-like
, leucine rich alpha 2 glycoprotein