Parkinson's disease

Parkinson's disease is one of the most well known neurodegenerative diseases. It is a chronic, progressive neurodegenerative disease characterized by both motor and nonmotor features. The disease has a significant clinical impact on patients, families, and caregivers through its progressive degenerative effects on mobility and muscle control.(1) An estimated 7 to 10 million people worldwide suffer from Parkinson's disease. antibodies-online offers a hand-picked number of antibodies, ELISA kits, recombinant proteins, as well as other tools for Parkinson's research.

Here you will find a list of important antibodies, reagents, kits, and other tools you need for your research in the field of Parkinson's disease, as well as some more additional resources on the topic.

Important Targets in Parkinson's Research

The following targets are directly related to research on Parkinson's disease. Search Antibodies, Kits, Reagents and other products. Click on a gene to see the available products.

Autosomal recessive and X-linked genes involved in Parkinson’s disease(2)

Gene Name Protein Name Involved Proteins
Parkin Ubiquitin-protein ligase
PINK1 PTEN-induced putative kinase 1
DJ-1 Oncogene DJ-1
ATP13A2 Lysosomal type 5 P-type ATPase
PLA2G6 Phospholipase A2
FBXO7 F-BOX only protein 7
DNAJC6 Putative tyrosine-protein phosphatase auxilin
PARK20 SYNJI Synaptojanin-1
TAF1 TFIID subunit 1

Autosomal dominant genes involved in Parkinson’s disease(2)

Gene Name Protein Name Involved Proteins
SNCA alpha-Syn
SPR Sepiapterin reductase in BH4 pathway
PARK4 Triplication of SNCA alpha-Syn
UCHLI Ubiquitin C-terminal hydrolase
LRRK2 Leucine-reach repeat kinase 2
GIGYF2 GRB10-interacting GYF protein 2
HTRA2 HTRA serine peptidase
PARK16 Multiple independent sites? Unknown
VPS35 Vacuolar protein sorting 35
EIF4G1 Eucaryotic translation initiation factor 4 gamma 1
DNAJC13 DNAJ-domain-bearing protein

alpha-Synuclein (SNCA) / PARK1

α-Synuclein is a presynaptic neuronal protein that is linked genetically and neuropathologically to Parkinson's disease (PD).(3) We offer a variety of reliable mono- and polyclonal SNCA antibodies.

Produkt Reaktivität Klonalität Applikation Kat. Nr. Menge Relevance ProductGrid: uniqueid
anti-Synuclein, alpha (SNCA) antibody Mammalian Monoclonal IHC (fro), IF, WB, ELISA ABIN536927 100 μL element-ABIN536927
anti-Synuclein, alpha (SNCA) (pSer129) antibody Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Primate, Rat (Rattus) Polyclonal WB ABIN2477391 0.1 mL element-ABIN2477391
anti-Synuclein, alpha (SNCA) antibody Human Polyclonal ABIN6148190 100 μL element-ABIN6148190
anti-Synuclein, alpha (SNCA) antibody Human Monoclonal ELISA, WB, IHC ABIN1724652 100 μL element-ABIN1724652

See all alpha-Synuclein Antibodies

LRRK2 / PARK8

As a promising target for neuroprotection strategies in PD, in vitro and in vivo models that accurately demonstrate LRRK2's function relevant to neurodegeneration will aide in the identification of molecules with the highest chance of success in the clinic.(4)

Produkt Reaktivität Klonalität Applikation Kat. Nr. Menge Relevance ProductGrid: uniqueid
anti-Leucine-Rich Repeat Kinase 2 (LRRK2) (AA 930-961) antibody Human, Mouse (Murine) Polyclonal ELISA, IF, WB ABIN3031610 0.4 mL element-ABIN3031610
anti-Leucine-Rich Repeat Kinase 2 (LRRK2) (C-Term) antibody Human, Mouse (Murine) Monoclonal ELISA, WB ABIN3031612 0.4 mL element-ABIN3031612
anti-Leucine-Rich Repeat Kinase 2 (LRRK2) (AA 878-909) antibody Human, Mouse (Murine) Polyclonal ELISA, IHC, WB ABIN3031607 0.4 mL element-ABIN3031607
anti-Leucine-Rich Repeat Kinase 2 (LRRK2) (AA 931-962) antibody Human Polyclonal ELISA, IHC, WB ABIN3028794 0.4 mL element-ABIN3028794

DJ-1 / PARK7

The DJ-1 gene is a causative gene for familial PD (park7) and also an oncogene. DJ-1 has various functions, including transcriptional regulation, antioxidative stress reaction, and chaperone, protease, and mitochondrial regulation.(5)

Produkt Reaktivität Klonalität Applikation Kat. Nr. Menge Relevance ProductGrid: uniqueid
anti-Parkinson Protein 7 (PARK7) antibody Human Polyclonal WB, ELISA ABIN545411 400 μL element-ABIN545411
anti-Parkinson Protein 7 (PARK7) antibody Human Monoclonal WB, ELISA ABIN532936 100 μL element-ABIN532936

See all DJ-1 Antibodies

Featured ELISA Kits

Here you will find a range of reliable ELISA kits with PubMed references for a number of PD related targets, which allow a quick and easy detection of proteins in biological samples. Click on the links to find more information.

Produkt Reaktivität Detection Method Kat. Nr. Menge Relevance ProductGrid: uniqueid
Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) IQ-ELISA Kit Human qPCR
(Pre-coated)		 ABIN6386150 96 tests element-ABIN6386150
Parkinson Protein 7 (PARK7) IQ-ELISA Kit Human qPCR
(Pre-coated)		 ABIN6386133 96 tests element-ABIN6386133
Synuclein, alpha (SNCA) ELISA Kit Rat (Rattus) Colorimetric
(Pre-coated)		 ABIN431993 96 tests element-ABIN431993
Parkinson Protein 7 (PARK7) ELISA Kit Mouse (Murine) Colorimetric
(Pre-coated)		 ABIN819944 96 tests element-ABIN819944
Synuclein, alpha (SNCA) ELISA Kit Mouse (Murine) Colorimetric
(Pre-coated)		 ABIN415770 96 tests element-ABIN415770
Synuclein, alpha (SNCA) ELISA Kit Human Colorimetric
(Pre-coated)		 ABIN414578 96 tests element-ABIN414578

References

(1) DeMaagd G, Philip A. Parkinson's Disease and Its Management: Part 1: Disease Entity, Risk Factors, Pathophysiology, Clinical Presentation, and Diagnosis. P T. 2015 Aug;40(8):504-32. PMID: 26236139; PMCID: PMC4517533.

(2) Emamzadeh, F. N., & Surguchov, A. (2018). Parkinson's Disease: Biomarkers, Treatment, and Risk Factors. Frontiers in neuroscience, 12, 612. doi:10.3389/fnins.2018.00612

(3) Stefanis L. α-Synuclein in Parkinson's disease. Cold Spring Harb Perspect Med. 2012 Feb;2(2):a009399. doi: 10.1101/cshperspect.a009399. PMID: 22355802; PMCID: PMC3281589.

(4) Webber PJ, West AB. LRRK2 in Parkinson's disease: function in cells and neurodegeneration. FEBS J. 2009 Nov;276(22):6436-44. doi: 10.1111/j.1742-4658.2009.07342.x.

(5) Ariga H, Takahashi-Niki K, Kato I, Maita H, Niki T, Iguchi-Ariga SM. Neuroprotective function of DJ-1 in Parkinson's disease. Oxid Med Cell Longev. 2013;2013:683920. doi: 10.1155/2013/683920. Epub 2013 May 16. PMID: 23766857; PMCID: PMC3671546.